Rheumatoid arthritis shine mai cike da ƙwayar cuta, mai kwaskwarima, autoimmune, nau'in ƙwayar cututtukan zuciya . Babu gwaji guda daya wanda ya tabbatar da ganewar asalin maganin wariyar launin fata. Wannan ya ce, gwajin kwayar jini na jini yana daga cikin ka'idojin da ake amfani dasu don gano cutar. Rheumatoid factor an gano a cikin 1940s. A cikin 'yan shekarun nan, an gano wani gwajin da aka sani da gwajin anti-CCP (anti-cyclic peptide antibody) wanda ya kasance da amfani a farkon wannan cuta.
Ƙunƙun dajiyar da aka haɗa tare da Lalacewa
Rheumatoid factor shi ne autoantibody, yawanci IgM, wanda ɗaure zuwa yankin Fc na IgG. Autoantibodies sunadaran sunadarai ne waɗanda ake samarwa ta hanyar tsarin rigakafi , amma suna kuskuren kai hari ga kayan jikin ta jiki maimakon na kai hare-haren abubuwa. Kasancewar daya ko duka biyu na autoantibodies, factor rheumatoid, da anti-CCP, ana kiransa da suturtawa ko maganin rheumatoid maganin ƙwayar cuta. Rashin jigon kwayoyin guda biyu a cikin jini na jini an san shi a matsayin lalatawa ko gadon maganin rheumatoid. Kimanin kashi 80 cikin dari na marasa lafiya da cututtukan zuciya na rheumatoid sune kwayoyin halitta don rheumatoid factor. Kimanin kashi 70 cikin 100 na marasa lafiya da cututtuka na rheumatoid sune kwayar cutar ta anti-CCP.
Bambanci a Cikin Cutar Cututtuka
An ba da shawara, dangane da nazarin asibiti, cewa marasa lafiya da cututtuka na rheumatoid da ke dauke da kwayar cutar suna fama da rashin lafiya da ci gaba da cutar, da mawuyacin halin rashin lafiya fiye da marasa lafiya da cututtuka na rheumatoid.
Zai zama kamar cewa marasa lafiyar da ke dauke da kwayar cutar suna buƙatar karin magani, amma wannan ra'ayi yana bayyana sau da yawa. A gaskiya ma, ƙaddamar da lalatawa zai iya yaudara.
Ƙwararren ƙwayar da aka sanya a matsayin ƙira zai iya samun autoantibodies wanda da farko sun kasance a cikin ƙananan matakin da za a iya gano.
Ainihin, mafi daidaitattun tsari ga wannan zai kasance "wanda ba a gane ba ko kuma wanda ba a gano shi ba". Akwai wasu lokuta masu amfani da autoantibodies a kunne wanda basu riga an gwada su ba. Alal misali, ban da anti-CCP da factor rheumatoid, magunguna da ake kira anti-CarP (protein-carbamylated gina jiki) na iya kasancewa a shekarun da suka gabata kafin a gano cutar cututtuka na rheumatoid. Anti-CarP ya kasance a cikin kimanin kashi 45 cikin dari na marasa lafiya na wutsiya na rheumatoid, har ma a cikin kashi 16 cikin dari na marasa lafiya na arthritis wanda ke da magungunan anti-CCP. An bayyana gaban antiCarP don tsinkayar wata hanyar cututtuka mai tsanani ga rheumatoid arthritis. Saboda haka, marasa lafiya marasa lafiya zasu iya samun ciwon cutar ko wata cuta kamar yadda marasa lafiya ke dauke da kwayar cutar kuma suna iya amsawa sosai ga mummunan magani (misali, DMARDs ko kwayoyin maganin kwayoyi ).
Shin Lalacewa na Tabbatar da Tabbatar Rikicin Arthritis Rheumatoid?
Zai yiwu a samu sakamakon mummunan sakamakon matsalar rheumatoid da anti-CCP, amma har yanzu ana bincikar su tare da cututtuka na rheumatoid. Bisa ga ka'idar ACR / EULAR na 2010 wanda ke da alaƙa na Rheumatoid Arthritis, kashi daya daga cikin 6 daga cikin 10 yana daidai da ganewar asali na maganin arthritis na rheumatoid. Hadin hadin gwiwa , gwajin maganin maganin maganin ƙwararru, masu gwagwarmaya mai tsayi, kuma tsawon lokacin bayyanar cututtuka an sha su a cikin wannan tsari.
Sabanin haka, mai haƙuri zai iya kasancewa mai kyau ga matsalar rheumatoid kuma kada a bincikar shi da cututtukan arthritis na rheumatoid. Sauran yanayi waɗanda zasu iya zama tabbatacce ga matsalar rheumatoid sun haɗa da:
- Sjogren ta ciwo
- Tsarin lupus erythematosus
- Scleroderma
- Polymyositis
- Dermatomyositis
- Ƙungiyar Haɗayyar Mixed Cututtuka
- Wasu cututtuka
An gano magungunan anti-CCP a wasu magunguna masu yawa a wasu cututtuka. Anti-CCP an dauke shi da ƙayyadaddun takaddama fiye da ka'idar rheumatoid don gano kwayar cutar wutsiya.
Sources:
Cutar sunadaran anti-carbamylated (anti-CarP) sun riga sun fara farkon maganin arthritis na rheumatoid. Shi J. et al. Annals na Rheumatic Diseases. 2014 Afrilu 73 (4): 780-3.
http://www.ncbi.nlm.nih.gov/pubmed/24336334
Jirgin anti-CCP na gwagwarmaya ta hanyar bincike da kuma kayan aiki na kwakwalwa a maganin arthritis na rheumatoid. Niewold TB et al. QJM. 2007 Afrilu, 100 (4): 193-201.
http://www.ncbi.nlm.nih.gov/pubmed/17434910
Rheumatoid Arthritis: Sakamakon da ke da hankali RA: Daidai amma Bambanci? Ajeganova da Huizinga. Yanayin Bayani Rheumatology. 11, 8-9 (2015).
http://www.nature.com/nrrheum/journal/v11/n1/full/nrrheum.2014.194.html
Kelley's Textbook na Rheumatology. Babi na 69. Ilimin Kimiyya da Tsarin Halitta na Rheumatoid Arthritis. Gary S. Firestein. Tsarin na tara.