Nazarin NIH Nazarin Amfani da Hormone na Tsufa Yanayin Lafiya
Yayinda mutane suka tsufa, matakan testosterone a jini suna saukowa. Wannan rushe a cikin testosterone an yi zaton cewa zai jagoranci abubuwa daban-daban, irin su rage halayen jima'i, anemia, kuma kashi ya karya.
Ana amfani da ƙarin maganin Testosterone da wasu likitoci don taimakawa tare da irin waɗannan matsaloli na jiki. A cikin 'yan shekarun nan, an sami ƙarin sha'awa a cikin asibiti na maganin testosterone a cikin tsofaffi.
Duk da haka, ba a gudanar da bincike mai tsawo ba don gano ko tabbatar da maganin testosterone yana taimakawa da irin waɗannan yanayi.
A shekara ta 2003, Cibiyar Kwalejin Cibiyar Magunguna ta yanke shawarar cewa babu cikakkun shaida da ke nuna goyon bayan testosterone a cikin tsofaffi kuma sun bada shawara don ci gaba da bincike. A sakamakon haka, a shekara ta 2010, Cibiyar Nazarin Kasa ta Duniya, wanda ke cikin NIH, ya kaddamar da gwajin Testosterone (T) don gano ko testosterone zai iya taimakawa tare da bayyanar cututtukan da ke da alaka da ƙananan matakan testosterone zuwa tsufa (watau hypogonadism ).
Twalolin T za su zama mafita ga tsawon lokaci da kuma ƙwarewar gwaji a nan gaba. Ƙarin sakamako daga T gwagwarmaya yanzu suna zuwa kuma an haɗu da sakamakon gaba ɗaya, tare da maye gurbin testosterone wanda ke hade da wasu amfani da wasu hadari. Dole ne a gudanar da bincike mai zurfi don gano ma'auni na wadatar da ake amfani da su da kuma hadarin da kuma ainihin asibiti na maganin testosterone.
T Tambayoyi Overview
Tannun T suna da jigilar gwaje-gwajen bakwai na gwaji da aka shirya a shafuka 12 a kusa da kasar. A cikin tara, mutane 790 da ke da shekara 65 ko babba tare da ƙananan matakan testosterone da alaƙa sun hada da bayyanar. Na farko, mahalarta sun cancanci daya daga cikin manyan gwaje-gwaje guda uku: Jarabar Jima'i, Jarabawar Jiki, ko Gwajiyar Jaraba.
Bayan haka, mahalarta zasu iya shiga kowane gwajin da suka cancanta.
Mafi mahimmanci, mahalarta suna buƙatar yin korafin rashin cin zarafin jima'i, rashin lahani na jiki, ko rage muhimmancin da za a fara a cikin T na gwaji. Bugu da ƙari kuma, an cire mahalarta wadanda ke da wasu yanayi, irin su ciwon gurguwar jini, matsalolin zuciya, matsalar koda, da sauransu.
A cikin dukkan gwaje-gwajen, an ba da mahalarta a kowane lokaci ko wani gwaji ko placebo. Maza a cikin rukunin gwaji sunyi amfani da gel testosterone kullum (AndroGel) na watanni 12; Duk da haka, ƙungiyar ta placebo ta karbi gel na wuribo (ba tare da testosterone) ba. An yi la'akari da masu halartar akai-akai.
Abin mahimmanci, an yi gwagwarmaya sau biyu, ma'ana masu binciken da mahalarta ba su san ko wane gel aka gudanar ba.
Ayyukan jima'i, aikin jiki, da gwaji
Sakamako daga farkon gwaje-gwaje uku aka ruwaito a cikin Fabrairu 2016 a New England Journal of Medicine .
Haɗuwa a cikin gwaji na Jima'i yana buƙatar masu halartar samun haɓaka a libido tare da abokin auren jima'i suna so su yi jima'i sau biyu a wata.
Haɗuwa a cikin gwaji na aikin jiki an buƙaci mahalarta suyi saurin gudu, matsalolin tafiya, da wahalar hawa matakan.
Mutanen da ba su iya tafiya ba, suna da ciwo mai tsanani, ko kuma sun kamu da cututtuka mai tsanani.
Ƙaddamarwa a cikin gwaji mai mahimmanci yana buƙatar masu halartar zama su zama marasa ƙarfi da gajiya.
Gyara matakan testosterone daga ƙananan zuwa al'ada na al'ada na inganta aikin jima'i a hankali (misali, jima'i, sha'awar jima'i, da kuma aiki mai gina jiki) da yanayin da kuma cututtuka na ciki. Duk da haka, ƙaramin testosterone bai inganta ƙarfin tafiya ko mahimmanci ba.
A takaice dai, masu bincike sun nuna cewa ba su da yawa masu halartar zartarwa a cikin waɗannan gwaje-gwaje uku.
Taron gwajin cutar
A watan Fabrairun 2017, an buga sakon daga jarrabawar Anmia.
Abun ciki shine yanayin da akwai rashi na jinin jini ko haemoglobin cikin jini. A kashi daya cikin uku na tsofaffi da ciwon jini, ƙwararrun likitoci ba za su iya kafa wata hanyar ba.
Tare da anemia, jikin baya karɓar isasshen jini mai arzikin oxygen, wadda ke dauke da hemoglobin dake cikin kwayoyin jini. Muriya zai iya zama m ko mai tsanani. Mutane da ke dauke da cutar anemia zasu iya jin rauni ko gaji. Sauran bayyanar cututtuka sun haɗa da rashin ƙarfi, rashin ƙarfi na numfashi, ko ciwon kai.
Anemia na dindindin zai iya lalata zuciya, kwakwalwa, da sauran gabobin. Lokaci-lokaci, mummunan mummunan jini zai iya haifar da mutuwa.
An gwada gwajin cutar ta Anemia don gano ko mutanen da suka tsufa da cutar anemia da ƙananan ƙwayoyin testosterone zasu iya samun ci gaba a matakan haemoglobin.
Sakamako daga jarrabawar gwaji sun nuna cewa akwai karuwa mai yawa a cikin haemoglobin a cikin maza biyu tare da anemia wanda ba a bayyana ba tare da maza da anemia daga sanannun sanannun da suka yi amfani da gel na testosterone. Wadannan sakamako zai iya kasancewa daga darajar asibiti, kuma ana iya amfani da maganin testosterone don bunkasa haɓakar hemoglobin a cikin maza fiye da 65 wadanda suna da anemia da basu da ƙananan testosterone. Duk da haka, ana buƙatar karin bincike.
Bone Trial
A watan Fabrairun 2017, an buga sakamakon daga Bone Trial.
Yayinda suke da shekaru, ba wai kawai suna samun raguwa a matakan testosterone ba, har ma suna raguwa a ƙananan ma'adinai, ƙananan kashi, da ƙarfin kashi da kuma karuwa a cikin fractures.
Bincike na farko game da ilimin testosterone akan kashin ba su da tabbas. Tare da Bone Trial, masu bincike sun yi ƙoƙari su gano ko ƙananan karfin ya karu bayan nazarin testosterone a cikin tsofaffi da matakan testosterone.
An kimanta yawan ƙananan abu ta hanyar amfani da x-ray absorptiometry (DEXA), kuma an kimanta ƙarfin kashi ta yin amfani da ƙididdigar lissafi (CT).
CT wata hanyar hoto ce ta amfani da hasken xi don ɗaukar hotuna na sassan jikin. DEXA yayi la'akari da yin amfani da ƙananan raƙuman x-rayuka don tantance ƙananan ma'adinai da lissafin ƙidaya. Watau ma'anar, DEXA yayi nazarin yadda yawanci da sauran ma'adanai ke cikin kashi.
Banda gaisuwa na bitamin D da ciwon ƙwayoyin calcium, mutane suna shan magungunan da suka shafi kashi da aka cire daga binciken. Bugu da ƙari, mutanen da ke da ƙananan ƙananan DEXA ba su daina daga binciken.
Masu bincike sun gano cewa mutanen da suka karbi magani na hormone sun sami karuwa a ƙarfin kashi da karfin. Ƙarin ƙarfin ya fi girma a cikin kashin baya fiye da yadda suke a cikin hanji. Duk da haka, kamar yadda yake tare da sauran T na T, ana bukatar karin bincike. Nazarin da ya fi girma akan shekaru da yawa zai bukaci a yi don sanin ko testosterone zai iya rage hadarin kasusuwa kashi.
Gwajiyar Ayyukan Kwarewa
A watan Fabrairun 2017, an buga sakon daga jarrabawar Ayyukan Kasuwanci.
A cewar Resnick da sauran marubuta na binciken:
Ƙungiyar yana haɗuwa da raguwa a wasu ayyuka na haɓaka, ciki har da ƙwaƙwalwar magana da na gani, aikin gudanarwa, da kuma ikon sararin samaniya. Tsufa a cikin maza yana haɗuwa da ragewa a cikin kwayoyin testosterone, ƙaddamar da yiwuwar cewa rage rarraba testosterone maida hankali zai iya taimakawa wajen komawa baya zuwa ga shekarun haihuwa.
A cikin wannan binciken, an ba mazan tsofaffi da ƙananan testosterone da ƙananan ƙwaƙwalwar ajiyar shekaru wanda aka ba testosterone. Mahimmancin ƙwaƙwalwar ajiyar shekarun da aka ƙayyade ya bayyana ta hanyar ƙwaƙwalwar ƙwaƙwalwar ajiya da rashin lahani akan gwaje-gwaje na ƙwaƙwalwar magana da na gani.
Wannan binciken bai nuna cewa maganin testosterone ya taimakawa wajen rashin kwakwalwar ƙwaƙwalwar da ake ciki ba.
Kwarar cutar kwakwalwa
Nazarin game da sakamakon testosterone akan sakamakon zuciya ba su da rikici. An tsara jarrabawar jijiyoyin jini don ƙayyade ko ƙarin ƙaramin testosterone a cikin tsofaffi da ƙananan ƙwayoyin testosterone zai iya jinkirta ci gaba da ƙarar murfin jini wanda ba a bayyana ba.
An yi jigilar ƙararrakin katakon maganin jini da ba a kwance ba tare da haɗin zuciya da kuma matsalolin zuciya. An jarraba ta ta amfani da maganin jinin jini wanda aka lissafa ta hanyar nazarin rubutun kalmomi, gwajin gwaji na musamman.
Masu bincike sun gano cewa a cikin maza suna daukar gel na testosterone, akwai karuwa mai girma a cikin ƙwaƙwalwar ƙwararrun murfin jini. Wannan binciken yana faruwa ne saboda karuwa a ƙarar murya yana rage karfin jini na jini, wanda zai iya rushewa. Harkokin maganin jijiyoyin zuciya suna ba da zuciya da jini.
Bugu da ƙari, kamar yadda yake tare da sauran T na T, ana bukatar karin bincike don gano ainihin abubuwan da wannan binciken yake.
Layin Ƙasa
Sakamakon wannan binciken ya nuna cewa maganin testosterone a cikin tsofaffi da ƙananan testosterone na iya haifar da wasu amfani. Duk da haka, maganin testosterone na iya haifar da hadari. Ba'a sani ba daidai da cinikin kasuwanci. Dole ne a yi nazarin karatu mai girma da tsayi don bayyana sakamakon ilimin testosterone a kan zuciya, jinin fata, nakasa, da sauransu.
Idan kun kasance mai tsufa da ƙananan testosterone da sha'awar shan testosterone, wannan shawara ya kamata a yi la'akari da hankali tare da likitan ku. Likitan likitanka zai iya yin la'akari da ma'auni na yanayinka da kuma maye gurbin hormone zai iya sa ka cikin hadarin gaske. Yana da mummunan ra'ayi ga wani ya shiga kariyar hormone ba tare da kulawa da likita ba. Dalili kawai saboda abubuwan da ke faruwa cikin jiki ba sa nufin cewa ana iya ɗaukar su ba tare da tasiri ba.
A ƙarshe kuma don ma'auni mai kyau, la'akari da wannan jagorancin shiri game da T Tambaya daga NIH:
Saboda T ana gwagwarmaya ne a cikin tsofaffi ba tare da wani dalili na rashin testosterone banda tsofaffi, waɗannan sakamakon ba su shafi maza da matakan hormone marasa ƙarfi don dalilai banda tsufa. Duk wani mutumin da yayi la'akari da maganin kwayar cutar ya kamata yayi magana akan yiwuwar da zai iya amfani da shi tare da mai kula da kiwon lafiya.
> Sources:
> Budoff, MJ, et al. Testosterone Jiyya da Coronary Artery Plaque Volume a cikin Tsofaffi Man Da Low Testosterone. JAMA. 2017; 317 (7): 708-716.
> Resnick, SM, et al. Testosterone Jiyya da kuma Ayyukan Ƙwarewa a Mazan Tsufa da Low Testosterone da Matsanancin Bayanan Ƙwaƙwalwar Age-Associated. JAMA. 2017; 317 (7): 717-727.
> Roy, CN, et al. Ƙungiyar Testosterone Matsayi tare da Abun Tutawa a Dattawan Akan Kwalejin Gwajin Inganci. JAMA Hoto Ciki. Fabrairu 21, 2017 (e-pub).
> Snyder, PJ, et al. Hanyoyin Testosterone Jiyya akan Ƙwararren Ƙwararren Halitta da Ƙarfafawa a Mazan Tsufa Da Low Testosterone Wani Jarabawar Kwayoyin Gina. JAMA Hoto Ciki. Fabrairu 21, 2017 (e-pub).
> Snyder, PJ, et al. Hanyoyi na Testosterone Jiyya a Dattawa. New England Journal of Medicine. 374 (7): 611-624.