An kiyasta kimanin mutane miliyan 33 da ke zaune tare da masu laushi ko kuma masu "lakabi": yanayin rashin jin dadi da yiwuwar yanayin kunya da wuya a magance. Domin fiye da shekaru talatin, babu sababbin kwayoyi don magance wannan yanayin. Duk da haka, a shekarar 2012, FDA ta amince da Myrbetriq (Mirabegron) don magance magungunan mai.
Overactive mafitsara ko kuma da'awar rashin tabbas yana nufin inganci na muscle detrusor.
Muscle detrusor wani ɓangare ne na bango mai mafitsara, kuma lokacin da yake da kyau, yana aiki da yawa, da kuma yaduwar iskar fitsari.
Overactive mafitsara shi ne mafi yawan tsari na urinary incontinence. Mata masu fama da wannan yanayin suna jin dadi sosai ga urinate wanda ba'a iya lura da shi ba. Maza suna fuskantar irin wannan cututtuka, amma za a iya yaduwa ta hanyar ciwon hawan zubar da jini na prostatic ko kuma ƙyama.
Magani na Zabin Zabuka
Kafin gabatarwa da Myrbetriq, an yi amfani da mafitsara mai amfani da magungunan pelvic (Kegel) da kuma biofeedback; gyare-gyaren rayuwa, irin su asarar nauyi ko maganin kafeyin; yabotulinumtoxinA ko Botox allura a cikin detrusor tsoka; da kuma maganin antimuscarinic irin su Detrol (tolterodine), Utrotrol (oxybutynin), da solifenacin.
Magunguna na Antimuscarinic suna da mummunar tasiri wanda ya sa su zama marasa damuwa ga mutane da dama da suka dauki su. Wadannan cututtuka masu haɗari sun hada da bushe baki, maƙarƙashiya, hangen nesa da rikice-rikice.
(Wannan damuwa yana haɗuwa da maganar, "Makafi kamar bat, mahaukaci kamar hatter, ja kamar gwoza, zafi kamar Hades, bushe a matsayin kasusuwa, ciwon zuciya da mafitsara ya rasa sautin, kuma zuciya tana tafiya kadai." )
Amfanin Myrbetriq
Myrbetriq ya fi dacewa a cikin ayyukansa fiye da maganin antimuscarinic da ake amfani dashi don biyan magungunan mai.
Myrbetriq kuma baya adawa da tsarin jin dadi kamar yadda kwayoyin antimuscarinic ke yi. Musamman, mirabegron ne mai beta - 3 adonergic agonist wanda ke kai hari ga masu karɓa a cikin ƙwayar detrusor (kashi 97 cikin dari na beta -3 mRNA da aka samar ta jikin mutum an samo shi a cikin ƙwayar detrusor).
Ba kamar antimuscarinic kwayoyi ba, mirabegron ba ya tsoma baki tare da masu karɓar beta-1 da beta-2 a wasu sassa na jiki. A wasu kalmomi, yayin da kwayoyi antimuscarinic suna da matsala mara kyau kuma suna shafar wasu tsarin kwayoyin halitta, mirabegron ya fi dacewa kuma yana rinjayar mafi yawan mafitsara.
Sakamakon gwaje-gwaje na asibiti da kuma Hanyoyi
A lokacin gwaji na II da na gwaji na gwaji na III, Myrbetriq aka gwada a cikin mahalarta fiye da 10,500. A cikin wadannan nazarin, mahalarta sun nuna rashin karuwar yawan ƙwayar fitsari, yawan adadin gaggawa, adadin abubuwan da ba tare da haɓaka ba da yawan adadin lalacewa (lalacewar dare)
Ko da yake Myrbetriq ya tabbatar da fiye da maganin antimuscarinic, yayin gwajin gwaji, wasu mutane har yanzu suna fama da mummunar tasiri ciki har da:
- ƙara yawan karfin jini
- urinary tract kamuwa da cuta
- zafi na ciki
- girman zuciya mai girma
- hawan jini
- sanyi-kamar bayyanar cututtuka
Ko da yake kara yawan ƙwayar zuciya da kuma karfin jini zuwa ga amfani da Myrbetriq suna da kyau, wasu masana sun damu da cututtukan zuciya na Myrbetriq.
Musamman tun kwanan wata, ƙananan bincike akan amfani da Myrbetriq a cikin tsofaffi na shekaru 70; Saboda haka, wasu likitoci ba su rubuta wannan magani ga marasa lafiya marasa lafiya da koda ba. Bugu da ƙari kuma, har yanzu babu tabbacin cewa Myrbetriq yana da tasiri idan aka yi amfani da kwayoyi antimuscarin.
A watan Agusta na 2015, FDA ta ba da jagorancin jagorancin abubuwan da suka faru tare da Myrbetriq. Bayan da aka saki miyagun ƙwayoyi zuwa ga jama'a, wasu mutane sun fuskanci haka:
- tashin zuciya
- angioedema (kumburi) na fuska, harshe ko larynx
- itchiness (pruritis)
Bayanin sakandaren angioedema na amfani da Myrbetriq zai iya zama barazanar rayuwa idan an rufe jirgin sama na sama.
Idan ka fuskanci angioedema ko wani game da bayyanar cututtuka bayan shan wannan magani, nan da nan ka kira sabis na gaggawa ko neman likitan da zai iya taimaka.
Bugu da ƙari, kasancewa da ya fi dacewa fiye da maganin antimuscarinic a gwajin gwagwarmaya, Myrbetriq ya tabbatar da inganta halayyar matakan rayuwa tare da mutanen da ke fama da mafitsara. Overall, Myrbetriq ya zama alamar sabuwar sabuwar hanyar magance magungunan magunguna musamman a tsakanin mutanen da basu iya jure wa kwayoyi antimuscarinic. Duk da haka, karin bincike dole ne a yi kafin mu fahimta yadda ya dace da magani tare da Myrbetriq.
Sources:
Chapple, CR. Mirabegron a Overactive Bladder: Binciken Ƙarfafawa, Tsaro, da Kwarewa. Neurourology da Urodynamics. 2013.
Harper G, Johnston C, Landefeld C. Geriatric Disorders. A cikin: Papadakis MA, McPhee SJ, Rabow MW. eds. Sanarwar Asibiti na Yanzu da Jiyya 2015 . New York, NY: McGraw-Hill; 2014.
Khullar V et al. Abubuwan da aka Yi Magana da haƙuri da Biko-Adrenoceptor Agonist Mirabegron a gwaji na III na gwaji a cikin marasa lafiya tare da Overactive Bladder. Neurourology da Urodynamics. 2015.
> Myrbetriq (mirabegron) Ƙaddamar da kwamfutar hannu. www.fda.gov.