Raunin Ciwon Kwayoyin Kwayoyin Kwayoyin Kwayoyi Mafi Saurin Bacewa na Parkinson
Multiple tsarin atrophy (MSA) wani ɓangaren cuta ne wanda zai sa sassa daban-daban na tsarin mai juyayi suyi girma. MSA ta ƙunshi ƙunƙwasa uku: Cikiwar Shy-Drager, ciwon striatonigral degeneration, and olivopontocerebellar atrophy. MSA ne ciwo mai ci gaba wanda ke shafi tsarin kulawa na jiki, bangare na jikinka wanda ke sarrafa abubuwan da ba a sani ba kamar narkewa da numfashi.
MSA tana rinjayar ko'ina daga mutane biyu zuwa 15 a kowace 100,000. Zai iya ɗaukar wani lokaci don karɓar ganewar MSA saboda kamance tsakanin MSA da sauran yanayi, irin su cutar Parkinson . An gano yawancin MSA kusan kimanin shekaru 50 kuma ana ganinsa a cikin dukan al'ummomi. Da zarar bayyanar cututtuka ta fara, cutar ta cigaba da cigaba da sauri.
Hanyoyin cututtuka na Multiple Atrophy
Hanyoyin cututtukan MSA sun fito ne daga asarar kwayoyin tausin jiki a cikin tsarin juyayi. Abin da ya sa wannan asarar jikin kwayoyin cutar ba a sani ba. Mutane da yawa tare da MSA na farko da aka lura da maganin kamala irin su urinary incontinence, cin hanci da rashin aiki a cikin maza, sauke cikin karfin jini lokacin da tsaye (orthostatic hypotension), rashin ƙarfi, da constipation. A yayin ci gaba da bayyanar cututtuka, suna yawan fadawa a ƙarƙashin ɗayan kungiyoyi biyu:
- Nau'in Parkinsonian (MSA-P): wannan ya hada da bayyanar cututtukan da ke kama da cutar Parkinson kamar fargaba a hutawa, ƙwaƙwalwar tsokoki, da raguwa
- Nau'in alamar ƙwayar cuta (MSA-C): ya haɗa da wahala ta tafiya (ataxia), al'amurra da suke da daidaito, da kuma matsala ta haɓaka ƙauna.
Sauran cututtuka da suka haɗa da MSA sun hada da wahalar magana ko haɗiye, barci mai barci, da hannayen sanyi. Wasu mutane na iya haifar da rashin barci, ƙuntata tsoka da ciwon hanzari, ciwo na Pisa - inda jikin ya bayyana yana kwance zuwa gefe ɗaya, da ƙwaƙwalwar zuciya, da kuma antecollis - wanda yakan faru lokacin da wuyansa ke ci gaba da kai ya sauka.
Yadda aka gano MSA
Zai iya zama da wuya a rarrabe MSA daga cutar ta Parkinson . Wata hanya ta bambanta tsakanin su shine duba yadda sauri cutar ta ci gaba. MSA tana kokarin ci gaba da sauri fiye da aikin Parkinson. Mutane da yawa tare da MSA zasu buƙaci wani kayan aiki, kamar sarƙaƙƙiya ko cane, a cikin shekaru da dama da aka gano su.
Wata hanya ta bambanta tsakanin su shine magance Parkinson. MSA ba ta amsa maganin levodopa ba, magani wanda ake amfani dashi don kula da Parkinson's. Abin baƙin ciki shine, autopsy shine kadai hanyar da za a gano ainihin MSA. Bincike na musamman, irin su PET dubawa (halayen watsi da haɗari), zai iya yin sarauta daga wasu nau'i na marasa lafiya.
Jiyya na MSA
A halin yanzu, babu maganin warkar da MSA, kuma babu wani magani wanda aka tsara musamman don sake juyawa ko dakatar da ci gaban cutar. Wasu bangarori na rashin lafiya suna da damuwa da wuya a bi da su. Damarar motsa jiki za a iya bi da shi tare da levodopa da cabidopa (Sinemet), amma wannan yana da iyakacin sakamako.
Sauran magunguna kamar bromocriptine (Parlodel), trihexyphenidyl (Artane), benztropine mesylate (Cogentin), da amantadine (Symmetrel), na iya bayar da wasu alamu na taimako.
Jirgin jiki, ciki har da farfadowa na ruwa, zai iya taimakawa wajen kula da aikin tsoka, kuma maganganun maganganu na iya taimakawa wajen magance matsalolin da suke haɗuwa ko magana.
Abin da Bincike ya ce
Kusan an san game da hanyoyin da ke aiki a cikin tsarin kwayoyin halitta. Masu bincike a Cibiyar Nazarin Ciwon Kwayoyin cuta da Harkokin Kasuwanci (NINDS) suna ƙoƙarin gano dalilin da yasa haɗin haɗin haɗin haɗin gine -ginen ya bunkasa a cikin kwayoyin da bazuka (kwayoyin da ke samar da kariya ga ƙananan ƙarfe a cikin tsarin jin tsoro) na mutane da MSA da neuronal (jijiya) Kwayoyin mutane da cutar Parkinson. An gwada gwaji a gwaji a amfani da rifampicin miyagun ƙwayoyi don rage ci gaba da cutar, amma magani bai da kyau.
Ana amfani da bayanai daga wannan binciken a wasu nazarin MSA.
Sources
Diedrich, A., & Robertson, D. (2002). Multiple tsarin atrophy. eMedicine, isa ga http://www.emedicine.com/neuro/topic671.htm
Ƙungiyar Cibiyar Kwayoyin Tsaro ta Duniya da Tashin Kashe. Multiple System Atrophy Fact Sheet. Nuwamba 2014.