Harvoni: Wani Magungunan Magungunan Kwayoyi da ke Kwarewa a Cutar Harshen C

by Naveed Saleh, MD, MS

1 -

All Hail, Harvoni!

Suna cewa ba za ku iya sanya farashi a kan lafiyarku ba. A fiye da dolar Amirka dubu 1000, sabon maganin miyagun kwayoyi, Harvoni , mai yiwuwa ya tabbatar da wannan ta'addanci.

Ranar 10 ga watan Oktobar, 2014, FDA ta amince da Harvoni, mai sauri, da sababbin magungunan da ake amfani da ita wajen cutar ciwon hauka na cutar ciwon hauka C. A shekarar 2014, Harvoni ita ce ta uku da FDA ta amince da ita don magance ciwon haifa C da kuma sananne don kyakkyawan tasiri da kuma sau ɗaya a rana.

2 -

Menene cutar kutsa C?

Hepatitis C wata kwayar cutar RNA ce wadda ke haifar da ciwon huhu ko ƙumburi na hanta. A halin yanzu, cutar kutsa C shine babbar hanyar cutar ciwon hanta a Amurka kuma yana rinjayar kashi 3 cikin dari na yawan mutanen duniya. Harsashin C yana yada ta jini ko samfurori, kuma kafin zuwan isasshen maganin cutar, mutane da yawa sun kamu da cutar bayan jinin jini. A halin yanzu, mafi yawan mutane suna ci gaba da ciwon hauka C bayan rarraba maciji yayin amfani da kwayoyi marasa lafiya.

Hepatitis C wani abu ne wanda ba zai iya haifar da rashin lafiya ba. Maimakon haka, yawancin mutane ana bincikar su bayan sun gabatar da cututtuka - a matsakaita, shekaru 10 zuwa 18 bayan sun kamu da cutar. Bugu da ƙari, kamuwa da cuta tare da ciwon cutar Cutar da ciwon hawan Cutar cutar ta haifar da cuta mai tsanani a cikin kashi 85 cikin dari na wadanda ke fama.

Hepatitis C yana da dangantaka mai suna ga hepatocytes ko hanta kwayoyin. Bugu da ƙari kuma, kwayar cutar ta ci gaba da sauri kuma ta haka yana da kyakkyawar aiki ta gujewa tsarin tsarin jiki. Dogon lokacin ko ciwon kumburi na ƙarshe yakan haifar da ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin jiki ko kuma mutuwar ƙwayoyin hanta da kuma cirrhosis. Cirrhosis ya bayyana a matsayin wani abu mai wuya wanda ya hade tare da nodules wanda ke ba da hanta a matsayin bayyanar "lumpy". Daga ƙarshe, ciwon haifa C yana kaiwa ga rage aikin hanta da hasara na hanta. A ƙarshe, kamuwa da cuta ta kullum tare da hepatitis C yana ƙara haɗari da ciwon hawan hepatocellular ko ciwon hanta. Bayanan lura, barasa, shan taba, kiba da haɗin kamuwa da juna tare da wasu cututtuka irin su HIV (ko ma cutar cutar hepatitis B) sa cutar rashin ciwon hauka C kamuwa da cutar.

3 -

Jiyya kafin zuwan kwayoyi kamar Harvoni

Wannan shekarar da ta gabata, FDA ta kasance a kan hawaye da kuma yarda da maganin 3 don maganin hepatitis C: Harvoni da 'yan uwanta na Olysio (simeprevir) da Sovaldi. Sau ɗaya a lokaci, duk da haka, kawai maganin miyagun ƙwayoyi da aka yi niyya a kan cutar cutar hepatitis C yana da dangantaka da Ribavirin. Wannan zabin, ko da yake yana da tasiri, ba shi da tasiri a yayin da yake maida martani ga maganganu ("magani") fiye da Harvoni da 'yan uwanta. Bugu da ƙari, interferon da Ribavirin suna da wuya a gudanar da aiki, suna da tsayi don gudanarwa kuma suna da mummunar tasiri fiye da kwayoyi kamar Harvoni.

4 -

To me Menene Harvoni?

Harvoni na da nau'i na kwayoyi da aka sani da su masu amfani da su. Wadannan kwayoyi sun fi dacewa da kuma tasiri a aikace-aikacen maganin cututtuka masu kama da kwayar cutar fiye da tsaka-tsaki da kuma Ribavirin. Da bayanin kula, Harvoni ya tabbatar da tasiri sosai a cikin mutanen da ke da tsayayya ga maganin cutar ciwon hawan Cit. Bugu da ƙari, Harvoni an gudanar da shi azaman haɗarin kwayoyin kwayoyin halitta kuma shine na farko a cikin ɗakantarsa don a gudanar ba tare da interferon da kuma Ribavirin ba. A cikin gwaje-gwaje na asibiti, fiye da kashi 90 na mahalarta, tare da kuma ba tare da cirrhosis ba, wanda ya karbi Harvoni ya sami nasarar amsa maganganu ("warkar") bayan bayanni 12 kawai.

5 -

Menene Harvoni Ma'anar Kai?

Idan kai ko wani wanda ka san yana da ciwon hauka C, Harvoni yana da magani sosai. Na farko, nazarin ya nuna cewa maganin rigakafin rigakafi da nufin kawar da cutar cutar hepatitis C zai iya inganta ilimin hanta da kuma hana ci gaba da hanta. Abu na biyu, Harvoni, wanda ya zo a cikin nau'in kwayar haɗari, ya fi tasiri da sauki don ɗauka fiye da tsarin da ake da shi a kan interferon da kuma Ribavirin. Na uku, Harvoni ya tabbatar da tasiri sosai a cikin mutanen da ke fuskantar maganin kututture na ciwon ciwon ciwon haifa C (marasa lafiya da cirrhosis ko genotype 1).

A bayanin ƙarshe, kwayoyi irin su Harvoni sun karbi takardun yawa don suna da tsada sosai. Tsarin makonni goma sha biyu zai iya biya wanda zai kashe $ 94,500 ko fiye da $ 1,000 a kwaya! (Ko kuma, dangane da yadda kake duban shi, farashin Mercedes-Benz S550.) Bugu da ƙari, yawancin shirye-shiryen Medicaid na jihar suna fama da wahala don rufe nauyin wannan magani kuma suna buƙatar marasa lafiya su bi wani tsari mai mahimmanci na tsarin kulawa. karbi kafin izni.

6 -

A Ainihin Final ...

Magunguna irin su Harvoni suna yin amfani da kwayoyi don tsada sosai. Tabbatar cewa suna kashe kudi mai yawa amma lafiyar lafiyar jama'a da kuma kimar kyauta ta hanyar maye gurbin - babu magani mai mahimmanci ga wadanda ke da ciwon hawan Cutar C ko da yaushe ba su wuce kusan adadin da ake yi na maganin. Ci gaban kwayoyi irin su Harvoni shine ainihin nasara na kiwon lafiya (kuma ban yi amfani da wannan kalma ba sauƙi). Wannan miyagun ƙwayoyi ya yi alkawarin taimakawa mutane da cutar da ta fi dacewa su guje wa rayuwa ta yau da kullum, kuma, hakika, sakamakon da irin wannan halin da ake ciki ya dauka a kan iyali, abokai da ƙaunatattun mutane.

_{Sakamakon Zaɓuɓɓuka}

_{Dienstag JL.} _{Babi na 304. Magungunan Inganci.} _{A: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds.} _{Ka'idodin Magungunan Hoto na Harrison, 18th.} _{New York, NY: McGraw-Hill;} _{2012. Samun shiga Oktoba 14, 2014.}

_{Dienstag JL.} _{Babi na 306. Harshen Hepatitis.} _{A: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds.} _{Ka'idodin Magungunan Hoto na Harrison, 18th.} _{New York, NY: McGraw-Hill;} _{2012. Samun shiga Oktoba 14, 2014.}

_{http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm376449.htm.} _{Samun shiga 10/14/2014.}

_{"Simeprevir don maganin cutar cutar hepatitis C" da Laure Izquierdo da al daga Pharmacogenetics da kuma Magunguna na Musamman da aka buga a Agusta 14, 2014. Samun damar 10/14/2014}

_{"Cutar Gwiwar Hanyoyin Harshen Cutar Hepatitis C" by Do Young Kim et al daga Gut Liver da aka buga a watan Satumbar 2014. Samun damar 10/14/2014.}

_{http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164256 /}

_{Ryan KJ, Ray C. Babi na 13. Tsaro na Hizeto.} _{A: Ryan KJ, Ray C. eds.} _{Sherris Medical Microbiology, 5th.} _{New York, NY: McGraw-Hill;} _{2010. Samun shiga Oktoba 14, 2014.}

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