Interferon wata magani ne wanda ke amfani da sinadaran jiki a cikin jiki cewa tsarin rigakafi yana amfani da shi don halakar da ƙwayoyin cuta. Maƙalar ƙwararren dangi ne wata hanyar ingantaccen miyagun ƙwayoyi wanda zai iya zama a cikin jiki ya fi tsayi, wanda ya samar da mafi alhẽri magani. Polyethylene glycol (PEG) an kara da shi zuwa interferon, wani tsari da ake kira pegylation, wanda aka yi amfani da wasu nau'o'in kwayoyi da.
Hakanan akwai wasu nau'o'i guda biyu da ake amfani da su tare da amfani da su don magance cutar ta Hepatitis C.
- Peginterferon alfa-2a: Har ila yau ake kira alfa-2a, sunan kasuwanci Pegasys.
- Peginterferon alfa-2b: Har ila yau ake kira alfa-2b, sunan kasuwanci PegIntron.
An dauke su da maganin zabi, da aka yi amfani da ribavirin, kuma aka jera a jerin Labaran Lafiya ta Duniya. Kula da HCV yana canza tare da yarda da Sofosbuvir (Sovaldi) da Simeprevir (Olysio) a 2013 ta FDA. Wadannan magunguna da wasu da suka biyo baya zasu iya kawar da magunguna a matsayin magani wanda aka fi so.
Babban bambanci a tsakanin waɗannan tsaka-tsaki guda biyu suna cikin dosing. Ana amfani da Alfa-2a a matsayin mako mai tsayayyen mako. Ana amfani da Alfa-2b a matsayin mako daya bisa nauyin mai haƙuri. Akwai wasu bambance-bambance tsakanin kwayoyi guda biyu, amma sune mafi yawan fasaha kuma likitan da ke rubutun suna amfani dashi.
Alal misali, alfa-2a yana da ma'ana mai mahimmanci bayan inji kuma an rarraba shi mafi yawa a cikin jini da gabobin. Amma alfa-2b yana da saurin sha da rarraba a cikin jiki.
Differences a cikin Inganci
Har zuwa Janairu 2008, babu wani bayanan da aka kwatanta da wannan magani. Wannan ya canza tare da babban binciken asibiti wanda aka sani da IDEAL kuma ya kara gwadawa na asibiti.
Wadannan suna samar da sakamako mai ban sha'awa wanda zai ba likitoci damar samun ƙarin fahimtar waɗannan maganin ilimin cutar hepatitis C.
Nazarin IDEAL - Ɗaukaka Dosing Dosing tare da Flat Dosing don Tattaunawa Mafi Mahimmanci Ƙwararrun Cibiyar Interferon - wanda ya haɗa da mutane 3070 a gwajin gwagwarmaya. Ya samo tasiri irin wannan tsakanin alfa-2a da alfa-2b don ci gaba da amsawar salula . Alfa-2a na da kashi 41% kuma alfa-2b na da SVR na 39%.
Amma al'amarin bai rufe ba. Bincike biyu da aka samu sun nuna bambanci tsakanin magungunan kwayoyi biyu, tare da alfa-2a wanda ya lashe nasara ta fiye da kashi 12% a cikin SVR.
Wani ƙarin nazarin maganin magungunan marasa lafiya 3518 daga cikin gwajin gwagwarmaya guda bakwai da aka samo asali sun sami sakamako mai kyau tare da alfa-2a, kodayake ya haifar da tsakaicin tsaka-tsakin neutropenia. Neutropenia shine raguwa a yawan adadin jini. Wannan wani sakamako ne wanda ba shi da kyawawa, don jinin jini sune mahimmin ɓangaren tsarin jiki. Lokacin da aka rage su, za ku zama mafi sauki ga kamuwa da cuta da kuma kasa da yakin da kwayoyin cuta da ƙwayoyin cuta suke yi.
Wadannan sakamako za a iya la'akari da lokacin da ake bada magani. Amma sababbin hanyoyin kwantar da hankali na iya kawar da magungunan ƙwayoyin cuta kamar yadda ake jiyya na zabi don ciwon hepatitis C.
Wannan shi ne yanayin bincike da bunƙasa. Zai yiwu ƙarshe ya zama abin ƙyama don kwatanta waɗannan kwayoyi guda biyu kamar yadda za a fi so da sababbin jiyya.
Sources:
Berenguer M, Wright TL. Hepatitis C. A: M Feldman, LS Friedman, LJ Brandt (eds), Gastrointestinal and Liver Liver, 8th . Philadelphia, Elsevier, 2006. 1701.
Tambaya C FAQs ga Ma'aikatan Lafiya, Oktoba 14, 2015. Cibiyoyin Kula da Cututtuka da Cututtuka
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