Harvoni wani maganin hade ne mai maganin ƙwayar cuta wanda aka yi amfani da shi wajen maganin rashin lafiya na ciwon hawan C-HCV . Magunguna biyu da suka hada da aikin Harvoni (ledipasvir, sofosbuvir) ta hanyar hana dukkanin sunadaran (NS5A) da kuma enzyme (RNA polymerase) mai mahimmanci don maganin cutar.
An amince da Harvoni a ranar 10 ga Oktoba, 2014, ta Cibiyar Abinci da Drugura ta Amirka (FDA) don amfani da manya shekaru 18 ko fiye da kamuwa da cutar HCV genotypes 1, ciki har da wadanda ke da cirrhosis .
Harvoni an yarda don amfani a cikin marasa lafiya (marasa lafiya-marasa lafiya) da marasa lafiya a baya, da wadanda ke da karɓa ko a'a don maganin HCV na farko ("jin dadin magani").
Harvoni ita ce likita ta HCV ta FDA da ta amince da ita wadda ba ta buƙatar ɗaukar ta tare da tareda interferon (peg-interferon) ko ribavirin (biyu da aka saba amfani dasu don HCV hade da farfadowa, dukansu suna da halayen haɗari masu haɗari).
An bayar da rahoton cewa Harvoni yana da magani daga 94% da 99%, yayin da gwajin Phase II ya bayar da rahoton lafiyar marasa lafiya 100% da aka kamu da HIV da HCV.
Yankewa
Ɗaya daga cikin kwamfutar hannu (90mg / 400mg) ana sha kullum tare da ko ba tare da abinci ba. Allunan Harvoni sune nau'i-lu'u-lu'u-lu'u, mai launin shuɗi, da kuma hotunan fina-finai, tare da "GSI" wanda aka saka a gefe ɗaya da "7985" a daya.
Bayyana shawarwarin
An tsara Harvoni a kan kati na 12 zuwa 24, kamar yadda wadannan shawarwari suka bayar:
- Jiyya-tsirar da ko ba tare da cirrhosis ba: makonni 12
- Jiyya-gogaggun ba tare da cirrhosis ba: makonni 12
- Jiyya-wanda aka samu tare da cirrhosis: makonni 24
Bugu da ƙari, za a iya yin nazari na mako takwas don magani-marasa lafiya marasa lafiya ba tare da cirrhosis wanda ke dauke da kwayar cutar ta HCV ba a ƙarƙashin miliyan 6 / ML.
Hanyoyin Kasuwanci
Hanyoyin da ke haɗuwa da amfani da Harvoni (wanda ke faruwa cikin 10% ko žasa marasa lafiya) sune:
- Wulo
- Ciwon kai
Sauran sakamako masu illa (a karkashin 10%) sun hada da tashin zuciya, zazzage, da rashin barci.
Drug Interactions
Dole ne a kauce wa wadannan a yayin amfani da Harvoni:
- Magunguna masu maganin tarin fuka-fuka na Rifampin: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Anticonvulsants: Tegretol, Dilantin, Trileptal, phenobarbital
- Aptivus (tipranavir / ritonavir) amfani da kwayar cutar HIV HIV
- St. John's Wort
Contraindications da tunani
Babu takaddama ga amfani da Harvoni a marasa lafiya tare da HCV genotype 1.
Duk da haka, ga marasa lafiya da kwayar cutar ta HIV ta amfani da magunguna na tenofovir (ciki har da Viread, Truvada , Atripla, Complera, Stribild ), ya kamata a ba da karin kulawa a lura da duk wani sakamako mai dangantaka da tenofovir, musamman ƙwayar koda (koda).
Dole ne a dauki tsaiko sau hudu 4 kafin ko bayan wani Harvoni, yayin da ake amfani da magungunan kwantar da hankalin proton da kuma masu hana masu karɓar H2 (masu satar H2 masu amfani) na iya ragewa domin hana rage rage jagoran jagorancin.
Duk da yake babu ƙin yarda game da amfani da Harvoni a cikin ciki, ƙananan bayanan asibitocin mutum yana samuwa. Duk da haka, nazarin dabba cikin amfani da jagoranci da sofosbuvir ba su nuna tasiri ga ci gaban tayi ba.
Ana bada shawarwari na musamman a lokacin daukar ciki don tantance yanayin gaggawa na Harvoni, musamman ma za a fara nan da nan ko kuma a jira har sai bayan bayarwa.
An ba da shawarar cewa a lura da dukan mata masu haihuwa a kowane wata don yin ciki a lokacin farfadowa. An kuma bada shawara cewa a yi wa mai haƙuri da mijinta damar akalla hanyoyi guda biyu na hana haihuwa da kuma amfani da su a lokacin farfadowa da kuma watanni shida bayan haka.
Source:
Cibiyar Abinci da Druggun Amurka (FDA). "FDA ta amince da maganin rigakafi na farko da za a bi da ciwon hawan Cutar C." Silver Spring, Maryland; sanarwa da aka buga a ranar 10 ga Oktoba, 2014.