Muhalli, Kwayoyin Halitta, da Al'umma
Eosinophilic esophagitis, ko EEE, an yi amfani da su a matsayin rashin tausayi. Duk da haka, tare da hanyoyi mafi mahimmanci kuma fahimtar bambancin da ke tsakanin GERD da EEE , yanzu ana la'akari da matsalar rashin lafiyar yara da manya tare da haɗarin matsalolin. Babu tabbacin cewa yaduwar EEE yana karuwa ne ko kuma kawai mun zama sananne game da esophagitis eosinophilic.
An gano likitoci na Eosinophilic ta hanyar samun biopsy na esophagus kuma suna ganin 15 eosinophils a ƙarƙashin maɓallin microscope mai karfi. Eosinophils ne kwayoyin jinin jini (wani ɓangare na tsarin rigakafi) wanda za'a iya hade da kumburi da kuma alaka da allergies. Mahimmanci na EEE da farko sun ragu, yayin da aka hade da wani nau'i na cututtuka da kuma magance shi tare da magunguna na proton-pump (wani magani don maganin cutar), kamar Prilosec.
Harsashin jini da cututtuka
Har yanzu akwai bincike mai gudana don taimakawa wajen ƙayyade ƙaddamarwa da kuma abubuwan haɗari da suke haɗuwa da eosinophilic esophagitis. Maza suna zama sau uku fiye da mata don samun EEE kuma za'a iya samuwa a cikin yara, matasa, da manya. Abun hankalin da ya fi dacewa da mutane suke da ita a lokacin neman magani shine:
- Difficulty swallowing (dysphagia)
- Ƙwannafi
- Nama
Can Acid Reflux Cause Eosinophilic Yanayi?
Maganin farko game da zubar da haɗarin esophagitis eosinophilic sun hada da lalacewa na esophagus da GERD ya haifar ko haɓakar acid daga ciki zuwa cikin esophagus.
Aikin acid zai lalata haɗin gwiwar tsuntsaye kuma ya bada izinin eosinophils su mamaye. Ba har zuwa tsakiyar shekarun 1990 ba lokacin da wannan hanya ya fara zama ba'a. Ba a yarda GERD ya zama dalilin EoE ba.
Abubuwan Hanyoyin Muhalli
An gano abubuwa masu muhalli a matsayin yiwuwar samun samfuran esophagitis eosinophilic.
Dalilin wannan shine mahimmancin abubuwan haɗarin muhalli da ke hade da ciwon asma da kuma cututtuka na fata. Ana tsammanin cewa ba'a iya ɗaukan hotuna da kwayoyin cutar da sauran microbes ba a farkon rayuwarsu na iya kasancewa dalilin mahimmancin EEE. Yanayi wanda zai iyakance kananan yara zuwa adadin kwayoyin da ya dace sun hada da:
- Cesarean sashen vs bayarwa na farji
- Haihuwar haihuwa
- Bukatar farko don maganin rigakafi a lokacin jariri
- Formula-fed vs shan-nono
- Rayuwa a yanki mai yawa
Yayin da kake ciki, tayin dinka yana da korar bakararre (imani na yau da kullum, amma ɗan ƙaramin gardama a kan wannan) ko ƙananan ƙwaƙwalwa ga kwayoyin cuta. A lokacin bazawar iska, jaririnka ya fallasa jikin kwayoyin da zai zama farkon farawa don ci gaba da kwayoyin kwakwalwa masu dacewa. Wannan shahararren ba ya faruwa a lokacin sashen cearean. Yana da muhimmanci a gane cewa akwai wasu dalilai masu kyau don samun sashin waxannan sassan da kuma hanya ta dacewa ta dacewa ya kamata a tattauna tare da obstetrician.
Dalili na Kwayoyin Halitta
Nazarin kwayoyin halitta wani ci gaba ne na binciken. Dangane da jinsin ziyartar eosinophilic, akwai abubuwa da dama da zasuyi la'akari game da kwayoyin halitta. Akwai nazarin da ke nuna mummunan haɗari ga samun EEE idan wani dan uwan ko iyaye yana da cutar.
Kusan 2 a cikin 100 iyalai suna da haɗarin iyali, duk da haka abubuwan da ke cikin muhalli sun bayyana sun sami dangantaka mai karfi. Wannan yana nufin cewa haɗarin iyali zai iya dangantaka da abubuwan muhalli da aka jera a sama.
Amma, akwai bincike da ya gano kwayoyin da ke shafar amsawar da jikinka ke ciki wanda zai iya haifar da kai ga samun samo asali:
- Rashin rashin lafiya a cikin rufi
- Ƙananan ƙwayar cuta
- Nawa kumburi
Lalacewa a cikin rufin katako mai yaduwa ya ba da dama don ƙãra ƙararrakin eosinophil zuwa esophagus lokacin da ake nunawa zuwa allergens. Ƙananan ƙonewa da alaka da esophagitis eosinophilic ya ƙirƙira madauwari da ramuka a tsakanin zobba.
Akwai kuma tsayin daka zama ruwan da yake kwance daga jikin saboda sakamakon ƙonewa, wanda ake kira exudate. Dogon lokaci, ko kuma na kullum, ƙonewa yana haifar da fibrosis, ko kuma tsummatu ko tsutsa wanda ya rushe jigon asophagus. Fibrosis yana daya daga cikin dalilan da ya sa zaka iya samun abinci a cikin bishiyarka idan kana da EEE.
Hanyoyi na Allergen Risk Factors
Ɗaya daga cikin manyan gano abubuwan hadari na ci gaban eosinophilic esophagitis shine rashin lafiyar abinci. Dangane da abincin abinci, ENT zai iya taimaka maka wajen sarrafawa na abincinka. Abincin da aka haɗa da EoE sun hada da:
- Dairy products
- Gwai
- Soy
- Alkama
Harkokin lafiyar muhalli na iya taka muhimmiyar rawa wajen bunkasa EEE. Hanyoyi masu haɗari na muhalli sun hada da rashin lafiyar zuwa:
- Dust mites
- Dander dabba
- Pollen
- Mould
Kuna iya lura cewa bayyanar ka na EEE ya zama muni a lokacin lokutan high pollen. Kuna iya ganin wani mahaukaci don ƙarin gwaji don bayyana abubuwan rashin lafiyar da zasu iya tsanantawa da alamar cututtuka. Idan ka ci gaba da nuna alamun bayyanar cututtuka ta EoE saboda rashin lafiyar muhalli, yana da muhimmanci muyi kokarin kawar da waɗannan abubuwan allergens daga gidanka .
Sources:
Cibiyar Kwalejin Allergy Asthma & Immunology. (2015). Eosinophilic Esophagitis (EEE).
Furuta, GT, & Katzka, DA (2015). Eosinophilic Esophagitis. N Engl J Med. 373: 1640-1648. Doi: 10.1056 / NEJMra1502863.
Kapel, RC, Miller, JK, Torres, C., Aksoy, S., Lash, R. & Katzka, DA (2008). Aminiya ta Eosinophilic: cuta mai yawa a Amurka wanda ke shafar dukkanin kungiyoyin shekaru. Gastroenterology. 134 (5): 1316-21. Doi: 10.1053 / j.gastro.2008.02.016.
Neu, J. & Rushing, J. (2011). Cesarean a kan Sauran Ƙarshe: Rawancin lokaci na jarirai da Tsarin Harkokin Tsaro. Clin Perinatol. 38 (2): 321-331. Doi: 10.1016 / j.clp.2011.03.008.