Cushing ta Syndrome ne ke faruwa ta hanyar wuce haddi Cortisol
Cushing ta ciwo shi ne cuta da ke faruwa a lokacin da jikin ke bayyana ga yawa cortisol. Cortisol ne ya samar da jiki kuma ana amfani dasu a cikin kwayoyi corticosteroid. Cushing ta ciwo zai iya faruwa ko dai saboda cortisol yana cike da jiki ta jiki ko kuma daga amfani da kwayoyi wanda ya ƙunshi cortisol (kamar prednisone). Lokacin da ciwon Cushing ya faru ne ta hanyar amfani da magungunan corticosteroid na dogon lokaci, an kira shi hypercortisolism.
Game da Cortisol
Cortisol ita ce babban hawan danniya. Cortisol an ɓoye shi ne ta wurin glandon da ke cikin kwatsam na adonocorticotropic hormone (ACTH) ta wurin pituitary. Wani nau'i na ciwo na Cushing na iya haifar da rashin rinjaye na ACTH ta hanyar pituitary da ke kai ga wuce gona da iri na cortisol.
Cortisol yana da ayyuka da yawa, ciki har da tsari na kumburi da kuma sarrafa yadda jiki yana amfani da carbohydrates, fats, da sunadarai. Corticosteroids irin su prednisone, wanda ake amfani da su don bi da yanayin inflammatory, mimic da sakamakon cortisol.
Dalili na Cushing ta Syndrome
Akwai wasu matsaloli daban-daban na Cushing's syndrome.
Cushing ta cuta. Cushing cuta ne daya dalilin da cutar Cushing ciwo da ke faruwa a lokacin da pituitary ya wuce wuce gona da iri ACTH, da haifar da karin cortisol da aka yi. Wannan zai iya haifar da ciwon sukari ko wasu ci gaban.
Iatrogenic Cushing ta Ciwo. Yin amfani da dogon maganin magungunan steroid na dogon lokaci zai iya haifar da wannan nau'in Cushing ta ciwo.
Ana amfani da kwayoyi masu tsire-tsire ko magungunan corticosteroid don magance yanayin ƙwayoyin cuta mai yawa, ciki har da ciwon fuka, lupus, cututtuka na rheumatoid, da kuma cututtukan zuciya mai ciwon jini (IBD) . A wasu lokuta, an tsara su a matsayi mai tsawo kuma na dogon lokaci.
Adrenal Gland Tumor. A ƙarshe, wani dalili, ko da yake ba shi da ƙaranci, ana haifar da shi ne ta hanyar kututture a kan gland.
Wadannan nau'o'in ciwon sukari suna haifar da ƙananan matakan cortisol, masu zaman kansu daga aikin ACTH daga gland shine. Lokacin da ƙwayar ta kasance kawai a cikin glanden adreshin, yawan ƙwayar cortisol da aka samar zai iya haifar da glandon adrenal wanda ba wanda ya shafa ya fara raguwa da raguwa.
Cutar cututtuka na Cushing ta Ciwo
Alamomi da alamun cututtuka na Cushing ta ciwo na iya hada da wadannan:
- kuraje
- Buffalo hump (karin mai da aka ajiye a bayan wuyansa)
- Girman glucose mai girma
- ƙishirwa da ƙishi
- gajiya
- ƙara urination
- ciwon kai
- hawan jini
- hirsutism (girma girma gashi)
- canje-canjen mata
- Kiba a kusa da akwati
- m bayyanar cututtuka irin su rashin lafiyar yanayi, damuwa, damuwa, tashin hankali
- zagaye, cikakken fuska (da aka sani da moon face)
- gyaran fata
- ƙuƙwalwa a cikin ciki, makamai, ƙirji, kwari, da cinya (wanda ake kira striae)
- rashin ƙarfi
Za a iya samun wasu alamu da alamomi na wannan yanayin da ba a rufe a sama ba. Yana da muhimmanci a ga likita tare da damuwa game da bayyanar cututtukan Cushing.
Sanin asalin Cushing ta Syndrome
Akwai bambancin halaye na jiki, irin su zagaye na wata da fuska, wanda ke cikin mutanen da ke fama da ciwon Cushing. Idan likitan likitancin Cushing ta, bayan tarihin yau da kullum, nazarin jiki, da kuma aikin jinin jini, zai umurce jini da gwagwarmayar gwaji don auna yawan adadin cortisol a jikin.
Idan matakan sun yi girma, likita na iya yin jigilar gwajin da ake kira gwajin gwajin dexamethasone. Wannan gwajin ne inda aka baiwa steroid mai suna dexamethasone kuma an sake gwada gwaje-gwajen jini da kuma fitsari don auna cortisol da sauran hormones. Ƙarin gwaje-gwaje za a iya yin umurni idan waɗannan gwaje-gwajen farko sun dawo tare da sakamakon da ke nuna alamar Cushing zai zama damuwa.
Kwararren likita zai iya motsawa zuwa gwajin gwaji mafi mahimmanci idan farkon binciken ya nuna cewa wannan wajibi ne. Idan ana zargin tsutsa a matsayin Cushing, wasu gwaje-gwaje da za a iya umurni sun haɗa da CT scan ko MRI .
Yayinda gwaji na iya zama kamar aiki mai yawa ko rashin dacewa, yana da muhimmanci a biyo bayan kammala dukkan gwajin da likita ya umarta.
Jiyya don Cushing ta ciwo
Cushing ta ciwo ne mafi kyau bi da ta hanyar ƙayyade abin da ke haifar da babban matakan cortisol da cire shi.
Cushing ta cuta. Hoto ne yawancin magani na farko don marasa lafiya da cutar Cushing. Ana cire tumɓin pituitary kuma wani lokacin duk glandon gwal, ta hanyar hanyar da ake kira gyaran shingeidal (bayan hanci) ta hanyar neurosurgeon ya fi dacewa. Idan ana bukatar cire dukkanin pituitary, dole ne a ba da kari na cortisol, thyroid, da kuma jima'i. Idan ana tilastawa tiyata ko kuma ƙwayar cutar ba za a iya cirewa ba, za'a iya amfani da farfajiyar radiation don rage ƙwayar. Idan an gano ƙwayar ya zama mummunan , chemotherapy ko radiation na iya zama wajabta don rage haɗarin harshe. Akwai maganin likita don magance cutar Cushing, har da Pasireotide (Signifor) da Mifepristone (Korlym).
Iatrogenic Cushing ta ciwo. Idan ciwon yana ciwo ta hanyar magani wanda aka ba da umarni, zai fi kyau fara fara maganin magani, wanda likita ya kula da shi, don cire sinadarin steroid. Yana da muhimmanci a hankali rage yawan adadin corticosteroid da aka yi a cikin makonni ko ma watanni. Za a iya samun magani daban-daban ko kuma wani magani mafi dacewa don yanayin da ya dace. Yana da muhimmanci a bi umarnin daidai, kamar yadda ba za'a iya tsayawa ba a kwatsam, amma dole ne a kashe shi a hankali.
Idan ba za'a iya dakatar da steroid ba, ko kuma idan zai dauki lokaci mai tsawo don dakatar da su, za'a iya ba da wasu jiyya don sarrafa wasu alamomi da alamun cutar Cushing. Wasu daga cikin sifofin wannan ciwon da zai buƙaci magani tare da wasu magunguna da canje-canje ga abincin sun hada da sukarin jini da high cholesterol. Rage haɗarin fractures da magunguna da ake amfani da su don magance osteoporosis zai zama mahimmanci. Idan akwai damuwa ko damuwa, mayar da hankali ga likita na likita don kulawa zai iya zama tasiri.
A Note Daga
A game da cutar Cushing, yawancin mutane sun warke lafiya bayan tiyata. Wasu alamun cutar na iya ci gaba bayan tiyata, irin su hauhawar jini, amma ana iya gudanar da su tare da magunguna. Idan tayi aiki ba zai yiwu ba, akwai magunguna na likita wanda zai iya rage yawan tasirin cortisol.
Cushing ta ciwo yana da haɗarin shan magungunan steroid, amma ba a saba ba. Yin amfani da kwayoyin cutar da kuma yiwuwar hadarin da ya kamata ya kamata a tattauna tare da likita. Cushing ta ciwo za a iya magance shi ta hanyar rage yawan adadin sitirin da ake dauka, kuma ta hanyar zalunta wasu alamu da alamun bayyanar. Manufar shine ko da yaushe don samun marasa lafiya a cire surar da sauri kuma a amince yadda ya kamata.
> Sources:
> Margulies, P. "Cututtuka na Adrenal - Cushing's Syndrome: Gaskiyar da ke Bukatar Ka sani." Ƙungiyar Cututtuka na Ƙasar Marasa ta Duniya. 2017.
> Cibiyoyin Lafiya na Ƙasar. "Cushing ta Syndrome." Cibiyar Nazarin Ciwon sukari da ƙwayoyin cututtuka da koda (NIDDK). Apr 2012.
> Sharma ST, Nieman LK. "Cushing ta ciwo: dukan bambance-bambancen, ganowa, da kuma magani." E ndocrinol Metab Clin North Am . 2011 Jun, 40: 379-391, viii-ix. Doi: 10.1016 / j.ecl.2011.01.006
> Sharma ST, Nieman LK. Cushing ta Syndrome: Duk bambancin, ganowa, da kuma magani. "Endocrinol Metab Clin North Am. 2011; 40: 379-391. Doi: 10.1016 / j.ecl.2011.01.006