Rheumatoid Arthritis Shine a Rituxan Nazarin Ya ƙaddamar Matsala PML
An gano wani mummunan hali na PML (mai ci gaba mai yawa) wanda aka gano a cikin likitan jini na Rheumatoid (RA) wanda ya shiga cikin gwajin gwaji na Rituxan (rituximab). Sakamakon haka, FDA da magunguna na masu amfani da miyagun ƙwayoyi sun ba da gargadi kuma zasu sabunta Rituxan mai bayanin bayanai don hada PML.
Menene PML?
PML kuma an san shi da ci gaba mai zurfi mai yawa na leukoencephalopathy.
Bisa ga Cibiyar Nazarin Ciwon Kwayoyin cutar Neurological and Stroke, "Ci gaba mai zurfi mai launi na rashin lafiya (PML) ya haifar da sake mayar da kwayar cuta guda daya a cikin tsarin kula da marasa lafiya wanda ke dauke da kwayar cuta. mafi yawancin mutane kuma ba mai cutar ba sai dai tsakanin wadanda suka sauke kare kare lafiyarsu. "
Shin Yafi Sanuwa Game da RA Wanda Ya Ƙera PML?
Mutumin RA ya fara gina cutar JC da kuma PML. Mutuwa daga PML ya faru ne bayan watanni 18 bayan mai haƙuri ya karbi kashi na ƙarshe na Rituxan a cikin binciken nazarin binciken lafiya.
Har ila yau, mai haƙuri na RA ya ci gaba da ciwon ciwon oropharyngeal ( cizon cizon kwari ) kuma aka magance ta da chemotherapy da radiation watanni 9 kafin inganta PML. Mai haƙuri yana da tarihin tarihin likita wanda zai iya taimakawa wajen bunkasa PML. Baya ga RA, mai haƙuri yana fama da ciwon Sjogren da kuma matakan C4 wanda ba a iya ba shi ba.
An magance masu haƙuri tare da matakan, steroids, da kuma TNF kafin suyi aiki tare da Rituxan. Ana amfani da methotrexate da steroids a lokacin da bayan rituximab magani.
Menene FDA ta Yi Amsawa ga Case na PML?
FDA tana sake duba umarnin da ke ba da umurni da kuma sanar da ma'aikatan lafiya a wata wasika da kuma jama'a a kan shafin yanar gizonta game da mummunar lamarin PML.
Menene ya kamata mutane marasa lafiya su yi tare da Rituxan?
Kamar yadda koyaushe, tattauna damuwa da likitanku. Masana sun bayar da shawarar cewa idan mai haƙuri da aka yi tare da Rituxan ya haifar da alamar cututtukan neurologic - dole ne a yi la'akari da shawara tare da wani neurologist, kwakwalwa ta MRI, da kuma lumbar. Magunguna waɗanda suka inganta PML su dakatar da Rituxan, yiwuwar dakatar da su ko rage wasu immunosuppressants, yayin da suke la'akari da farfadowa da maganin rigakafi. Amma, babu wani magani wanda zai iya warware PML idan ya taso.
Sources:
FDA: Matsayi mai yawa na ci gaba mai yawa Leukoencephalopathy a cikin haƙuri Mai karɓar Rituximab. Doctor's Guide News . Satumba 11, 2008.
FAD Medwatch. Muhimmiyar Mahimmin Bayanin Tsaro game da Mahimmancin Magancewar Lafiya da Lafiya tare da Amfani da Rituxan. Satumba 11, 2008.