Cutar cututtuka, MRI, da Lumbar Puncture zuwa Diagnosis PML
Maganin rashin ci gaba mai zurfi (PML) yana da cutar ciwon kwakwalwa ta cutar ta JC . Wannan cutar bata haifar da wani bayyanar cututtuka lokacin da yake cutar da mutum, yana kwance a cikin jiki. Amma lokacin da tsarin mutum ya raunana (kamar a cikin cutar AIDS, Lupus, ko wasu cututtuka), za a iya sake cutar da kwayar cutar, tare da kamuwa da kwayoyin halitta wadanda ke yin myelin (sanadin jikin ku) - wannan shine ilmin halitta a bayan PML.
Muhimmancin PML a cikin MS shine cewa yana da tasiri sosai na wasu cututtuka na gyaran cutar , mafi mahimmanci, Tysabri (natalizumab).
Har ila yau, akwai magoya bayan PML a cikin mutane tare da MS waɗanda suka dauki Gilenya (fingolimod), Tecfidera (dimethyl fumarate), ko Ocrevus (ocrelizumab).
Sanarwar wannan cutar mai cututtuka na bukatar buƙatarwa sosai ta hanyar likita ciki har da cikakken tarihi da jarrabawar jiki, MRI na kwakwalwa, da kuma ƙuƙwalwar lumbar .
Gwaji don cutar JC a cikin Cerebrospinal fluid
Don gano asali na PML, likita za ta yi amfani da shi don yin nazarin kwayar cututtuka (CSF) don kasancewar cutar ta JC. Anyi wannan ta hanyar yin gwaje-gwajen polymerase (PCR) akan CSF don ganin idan DNA na JC cutar ke nan.
Sakamakon gwajin PCR don bincika kwayar JC a cikin ruwa mai gishiri za a hada shi tare da binciken binciken asibiti (alamomin PML) da kuma sakamakon MRI don isa a ganewar asali.
MRI don Tattaunawa na PML
Za'a yi umurni da hotunan fuska mai haske (MRI) akan kwakwalwa. A MRI, PML yakan nuna a matsayin ƙananan ƙananan ƙananan raunuka . Zai yiwu su haɗu da juna su zama babban launi.
Kwayoyin cututtuka don Bincike PML
Dandanku zai so ya san ainihin yadda kuka ji da kuma lokacin da sabon alamominku ya fara.
Yana da muhimmanci a yi daidai da cikakken bayani a cikin bayaninku. Lissafi na PML suna da yawa amma suna iya haɗawa da canji a cikin tunani da hali, hasara na daidaituwa, matsalolin hangen nesa, ƙarar rauni na makamai ko kafafu, ciwon kai, ko sutura.
Wasu lokuta yana iya ƙalubalanci don gane bambancin bayyanar da MS ta dawo daga PML. Ɗaya daga cikin alamu, bisa ga binciken da aka yi a 2009 a cikin Tarihin Mahimmancin Labaran, shine mutumin da ke da suturar MS yana da alamar farko, yayin da mutanen da ke tare da PML suna da alamun bayyanar.
Brain Biopsy don Tattaunawa PML
Idan mutum yana kan Tysabri, gwaje-gwaje da kyau ga cutar JC tare da gwajin PCR CSF, ya nuna alamun bayyanar PML, kuma yana da MRI dubawa tare da binciken da ya dace da PML, mai yiwuwa likita zai bi da PML. Wani lokaci, duk da haka, an yi kwakwalwa ta kwakwalwa.
Kwayar kwakwalwa ta kwakwalwa shine cire wasu ƙananan sassa na kwakwalwar kwakwalwa don amfani da ganewar asali na PML. Kwayoyin nama suna nazarin kwayar cutar JC.
Halittar kwakwalwa ta kwakwalwa shine "ma'auni na zinariya" na gwaje-gwaje na gwaji don PML. Duk da haka, yana dauke da hadari, ciki har da mutuwa. Bugu da ƙari, ƙwayoyin PML bazai yiwu ba ne don samun samfurin biopsy. Ba dole ba ne a ce, wannan ba hanya ce mai kyau ba tare da marasa lafiya ko likitoci, kuma ba wanda ake amfani dashi sai dai a cikin mafi yawan yanayi, domin ya fitar da wasu cututtuka.
Idan akwai mutumin da yake tare da MS wanda yake a Tysabri, wannan ba shi da wata matsala fiye da mutumin da ke dauke da kwayar cutar HIV / AIDs, kamar yadda yawancin cututtuka da za su iya yin amfani da PML (toxoplasmosis, meningitis cryptococcal, ko ciwon daji na cutar AIDS) watakila.
Kalma Daga
Idan za ku fara samun wani abu mai ban mamaki ko kuma haɓaka bayyanar cutar yayin da yake a Tysabri (ko wasu sha'anin maganin cutar MS) ya tuntuɓi likitanku nan da nan. Kada ku ɗauka cewa "kawai komawar MS" ko kuma alamun bayyanar cututtuka. Samun dubawa da wuri-wuri. Nan da nan an fara kula da PML, mafi kyau ga chancesanka don rayuwa.
> Sources:
> Boster A et al. Nasarar ci gaba mai yawa da kuma lalatawa-maida hankali kan sclerosis: nazarin nazari. Arch Neurol. 2009 May, 66 (5): 593-9.
> Clifford DB et al. Ma'aikata na Natalizumab da ke haɗuwa da ƙwayar cuta mai yawa a cikin marasa lafiya tare da ƙananan sclerosis: darussa daga lambobi 28. Lancet Neurol . 2010 Afrilu 9 (4): 438-46.
> MS Society na kasa (2015). Ra'ayin PML An Bayyana a cikin Mai karɓar Gilenya: UPDATED. da kuma > Rubutu na PML da aka ruwaito a cikin Takaddun Tecfidera.
> Ƙungiyar MS ta kasa (2017). Ra'ayin PML da aka ambata a cikin Mutum Mai karɓar Ocrevus don bi da MS.
> PML Consortium. Ma'aikatan Lafiya: Menene PML?