Har ila yau, synovium, wanda ake kira da membrane synovial, shine abin tausin da ke cikin layin da ke tattare da kwakwalwan katako, sutura, da bursa. Lines na yau da kullum sun hada da dukkan ciki na haɗin gwiwa, sai dai inda aka haɗa da haɗin gwiwa tare da guringuntsi . Saharar tana da launi na waje (subintima) da kuma ciki na ciki (intima). Kwayoyin da ake kira suna synoviocytes.
Akwai nau'o'in synoviocytes guda biyu, rubuta A (samfurin macrophage) da kuma rubuta B (fibroblast). Ƙarin subintima yana kunshe da ƙananan hanyoyi (a cikin haɗin gwiwa), irin su tasoshin jini da tasoshin lymphatic, da jijiyoyi. A ƙarƙashin duniyar synoviocytes, akwai ko dai adipose nama ko fibrous nama. Sabanin shine inda ake samar da ruwa mai gina jiki, abu ne wanda ke lubricate kuma yana inganta furotin da kasusuwa cikin haɗin gwiwa.
Synovium a Rheumatoid Arthritis
Kamar sauran cututtukan rheumatic da yawa, cututtuka na rheumatoid wani cututtuka ne . A cikin wata cuta ko yanayin jiki, tsarin mutum na rigakafi , wanda yakan taimakawa kare jiki daga kamuwa da cuta da cuta, ya kai wa kansu kayan haɗin gwiwa don dalilai maras sani. A cikin cututtukan cututtuka na rheumatoid, kwayoyin halitta marasa tsari sun tafi zuwa synovium kuma suna fara ƙonewa (synovitis). Hanyar ƙin ƙwayar cuta tana haifar da yaduwa da kwayoyin synovial, ƙara yawan fascularization, da kuma lalata jiki ta ƙwayoyin ƙwayoyin cuta, ciki har da lymphocytes, kwayoyin plasma, da macrophages da aka kunna.
Wannan ya nuna kanta a matsayin bayyanar cututtuka na rutumatuid arthritis- zafi , redness, busa, da zafi.
Kamar yadda ciwon arthritis ke ci gaba, ƙwaƙwalwar ƙwayar cutar ta mamaye kuma ta lalata ƙafafun da ƙashi na haɗin gwiwa. Jigun da ke kewaye, hagu, da kuma tendons wanda ke tallafawa da karfafa tsarin haɗin gwiwa ya zama rauni kuma basu iya yin aiki kullum.
Wadannan cututtuka suna haifar da ciwon haɗin gwiwa da haɗin haɗin gwiwar da aka gani da yawa a cikin mutanen da ke dauke da maganin arthritis. Fahimtar abin da ke faruwa a synovium a arthritis na rheumatoid yana taimaka maka ka fahimci bayyanar cututtuka da cututtukan cututtuka.
Jiyya don Tarwatsa Flamed Synovium - Shin yana zuwa?
An samu sha'awa tsakanin masu bincike game da ci gaba da maganin ƙwayoyin nama don maganin cututtuka na rheumatoid. Hakanan, kwayoyi zasu iya janyo hankalin synovium tare da ƙara yawan inganci yayin da yake rage yawan ciwon haɗari. Idan wannan ya kasance mai yiwuwa, za a iya ba da izinin daukar hotunan samfurin a cikin synovium, don ƙaddamar da synovite mai aiki a cikin ɗakunan mahaɗai. Duk da yake akwai ci gaba a wannan yanki, ba a gano wani mai karɓa na synovial ba.
> Sources:
> Freemont, Anthony J. The Pathophysiology na Cartilage da Synovium. Jaridar British Journal of Rheumatology. 1996; 35 (suppl.3): 10-13.
> Garrood T. da Pitzalis C. Guddawar Inflamed Synovium. Binciken na Musamman. Arthritis da Rheumatism. Afrilu 2006.
> Kelley's Textbook na Rheumatology. Tsarin na tara. Firestein et al. Binciken Halittu na Haɗin Haɗin Kasuwanci. Shafuka na 8-10.
> O'Connell, John X., MB FRCPC. Pathology na Synovium. American Journal of Clinical Pathology.
> Smith, Malcolm D. The Normal Synovium. Jaridar Rheumatology ta Gida. 2011; 5: 100-106.