Nazarin Hanya na 2 na Kamfanin Yayi Nazarin Matsayi Mai Girma Mai Girma Zai Yi Amfani da MS
Mace masu ciki da ƙwararrun sclerosis suna da kashi 70 cikin dari na rage hadarin samun ciwon sake dawowa a lokacin bana na uku, kuma masana sunyi imanin cewa jima'i na jima'i na hormone estriol na iya taka muhimmiyar rawa a cikin wannan kariya.
Estriol shine nau'in estrogen wanda yake da mahimmancin ciki. An yi shi ne daga mahaifa kuma ya kai matakanta mafi girma a lokacin bana na uku.
Abin farin ciki shi ne cewa masana kimiyya suna kallon yin amfani da ita don amfani da MS, tare da fatan za su jinkirta cutar.
Kimiyya Bayan Ta Amfani da Estriol Don Rage MS
Akwai nazarin karatu na biyu na biyu wanda ya bada shawara cewa ɗan adam zai iya zama tasiri a rage ragewar MS. An yi nazari na biyu na Phase 2 don tantance lafiyar kwayar magani kuma ko yana iya zama da amfani. Nazarin 3 na zamani, wanda ya fi girma kuma ya fi tsayi, ana buƙata don amincewa da magani daga Cibiyar Abinci da Drugke ta Amurka (FDA). Saboda haka wannan shine farkon bayanai, amma duk da haka ban sha'awa.
A cikin binciken shekara biyu na shekara ta 2016 a cikin Lancet Neurology , mata 164 tare da sake dawo da MS (masu shekaru 18 zuwa 50) sun kasance bazuwar su karbi ko wane mita 8 na dayari ko rana ta kowace rana. Babu mahalarta ko masu binciken binciken sun san abin da aka raba wa mace. Masu halartar sun dauki kwayar yau da kullum ko kwayar wuri tare da saba'in na yau da kullum na Copaxone (acetate glatiramer) - wanda mahalarta suka fara kwanan nan.
Sakamakon binciken ya nuna cewa bayan watanni 12, an sami raguwar karuwar yawan kuɗuwa na shekara-shekara a cikin mahalarta daukar Copaxone da estriol, idan aka kwatanta da wadanda ke daukar Copaxone da placebo. Amma a ƙarshen shekaru biyu, karuwar yawan kuɗi na shekara-shekara tsakanin masu cin gashin kai da wadanda ke da matsakaicin matsakaicin abu ne kawai (idan a kowane lokaci).
Ganin cewa sakamakon binciken ya fara alkawurrawa, ba abin da ya sa ba a gano ragowar sake dawowa bayan shekaru biyu, kamar yadda aka gani bayan shekara guda. Masana sun bayar da shawarar cewa maimaita karatun tare da mahalarta mahalarta zasu taimaka.
A wani bayanin kula, ƙungiyar Copaxone da 'yan kuɗi sun sami gagarumin cigaba tare da gajiya, idan aka kwatanta da ƙungiyar Copaxone kawai.
Labari mai dadi shi ne cewa an yarda da dan jariri a cikin binciken. Alal misali, dangane da tayar da ƙwayar cuta na fibrocystic nono , ciwon nono, ko kuma mai ɗaukar nauyin uterine (duka damuwa na daukar nau'i na estrogen), babu wata babbar bambanci tsakanin matan da suka dauki 'yanci da waɗanda ba su yi ba. Abinda ya bambanta tsakanin kungiyoyi guda biyu shi ne cewa hawan karuwanci a cikin mata sun kasance mafi yawanci a cikin matan da suka dauki 'yan kuɗi fiye da matan da basu yi hakan ba. Rashin ciwo na rashin lafiya ba su da yawa a cikin matan da suka dauki 'yanci fiye da matan da basu yi ba.
A cikin wani karamin bincike na 2002 a cikin Annals of Neurology, mata goma da ba a ciki ba tare da MS sun karu da 8mg yau da kullum na masu tsauraran ra'ayi da kuma kwakwalwa ta MRI. Sakamakon ya nuna rashin karuwa a yawan adadin gadolinium na ingantawa a cikin watanni shida a yayin da ake jiyya tare da estriol, idan aka kwatanta da watanni shida kafin kafin jiyya.
Bugu da ƙari, a lokacin da aka dakatar da jinin mata na watanni shida, adadin ƙwayoyin haɓakar haɓalin haɓurwa sun sake komawa matakan kirkiro ko matakai. Amma bayan watanni huɗu na sake farawa da tayi, lambar labarinsu ta sake komawa a cikin kwakwalwa ta MRI-wannan nazari na gaba da gaba yana jaddada amfanin da ke cikin ɗan ƙaramin binciken.
Fahimtar Matsayi na Estriol a cikin MS
Estrogen ne jimlar jima'i mafi yawa samar da mace biyu ovaries kuma yana da alhakin bunkasa jikinta na haihuwa (mahaifa, farji, fallopian tubes, ovaries). Estrogen kuma tana taka muhimmiyar rawa a haila, haɓaka nono, ciki, da kuma kashin nama.
Akwai nau'o'i daban-daban na daban daban daban daban daban da aka samar a cikin jiki:
- estradiol
- estrone
- estriol
Ba kamar isradiol da estrone ba, isriol na musamman ne a cikin ciki kuma yana ɗaukar rauni ga masu karɓar isrogen (wuraren shaƙatawa) dake cikin sel cikin jiki.
A game da amfani da ƙwayar sclerosis, masanan kimiyya sunyi imanin cewa estriol tana taka muhimmiyar rawa wajen kare tsarin kulawa ta tsakiya. Ana nuna wannan ta hanyar nazarin da ke nuna alamar isriol ga masu karɓar isrogen a cikin tsarin rigakafi, kwakwalwa, da kuma kashin baya. A gaskiya, ba da izini ga ƙuda da gwajin motsa jiki na gwaji na MSN, ko EAE (siffar motsi na MS), an samo shi don hana ciwon ƙwayar asali da kuma asarar myelin-myelin kasancewa mai kare lafiyar karewa wanda ya lalace a cikin MS.
Wannan yana cewa, masana sunyi imanin cewa estriol ne mafi ƙarancin da ba shi da magungunan ƙananan ƙwayoyin cuta-ma'anar shi yana kare kwakwalwa da ƙwararren ƙwayoyin cuta daga ƙwayar sallar myelin da ƙwayar jijiya (axon), amma baya hana kumburi a cikin tsarin kulawa na tsakiya. Wannan shi ne dalilin da yasa za'a yi amfani da maganin maganin cutar shan taba (kamar daya daga cikin hanyoyin maganin cututtuka na yau da kullum) tare da haɓaka tare da estriol don magance MS.
Menene Wannan Ma'anar Na?
Yana da mahimmanci a lura cewa an ba da izini don amfani a Amurka, kodayake ana amfani dashi don magance matsalolin mazaopausal kamar walƙiya mai zafi da kuma bushewa a cikin Turai da Asiya.
Ana ɗaukar saƙo na gida a nan shi ne cewa, yayin da dan takara na MS ya yi alkawarin, kimiyya a baya bayanan da kuma aikinsa na kare lafiyar cutar a cikin MS ba a cika shi ba. Dole ne a kammala binciken farko, ciki har da nazarin zamani 3. Ka'idoji na daukar lokaci don bunkasa, wanda shine abu mai kyau a ƙarshen lafiyarka da aminci.
Sources:
Bebo BF Jr, Fyfe-Johnson A, Adlard K, Beam AG, Vanderbark AA, Offner H. Sauran ƙwayoyin cin hanci da rashawa na zartar da zartar da ciwon estrogen na biyu a cikin nau'i-nau'i daban-daban. J Immunol. 2001 Feb 1; 166 (3): 2080-9.
Confavreux C, Hutchinson M, Hours MM, Cortinovis-Tourniaire P, Moreau T. Turawar sake komawa cikin ciki a ƙwayar sclerosis. Tashin ciki a cikin Multiple Sclerosis Group. N Engl J Med 1998 Jul 30; 339 (5): 285-91.
Spence RD, da Voskuhl RR: Neuroprotective sakamakon estrogens da androgens a CNS kumburi da neurodegeneration. Gabatarwar Neuroendocrinol 2012; 33: pp. 105-115.
Sicotte et al. Jiyya na mahara sclerosis tare da ciki hormone estriol. Ann Neurol 2002 Oktoba; 52 (4): 421-8.
Voskuhl RR et al. An yi amfani da Estriol tare da acetate glatiramer ga mata tare da sake dawowa-maidawa sclerosis mai yawa: tsarin gwaji, wuri-mai sarrafawa, lokaci na biyu. Lancet Neurol . 2016 Jan; 15 (1): 35-46.