A cikin haɗin gwiwa, an bayyana nau'in nau'in nau'in haɗin gwaninta (wanda ake kira synovium ko ruɗin haɗin gwiwa) wanda ke rufe furen haɗin gwiwar , irin guringun da ke cikin ɗakunan. Yayin da synovium ya kara ƙaruwa kuma ya haɓaka, haɗin haɗuwa ya cika da launi da ƙananan synovium suka yi ƙaura a fadin furen manya, yana haifar da yaduwa.
A cikin arthritis na rheumatoid, yatsun suna farawa a gefen haɗin gwiwa. Yayin da ci gaba yana ci gaba, zai iya kutsawa kashi da kasusuwa na kasusuwa , sa'annan ya halakar da siffofin kewaye, kamar su hade da haɗin gwiwa.
Kwatanta Pannus a Osteoarthritis da Rheumatoid Arthritis
Ba a sani ba sosai game da hali na pannus a osteoarthritis idan aka kwatanta da pannus a rheumatoid arthritis . Masu bincike sunyi nazari kan manufar kwatanta osteoarthritis pannus tare da kwayar cutar wariyar launin fata a cikin vitro (a cikin Lab Labarin) a shekarar 2008. Sakamako da aka buga a Clinical Rheumatology sun sami daidaito a tsakanin osteoarthritis da rheumatoid arthritis pannus - amma me yasa osteoarthritis pannus ya mamaye fureti amma amma ba a haifar da mummunar yaduwa da ake gani a cikin rheumatoid arthritis ba a bayyana.
A cikin nazarin, an samu nau'in pannus da kayan aikin synovial daga marasa lafiya 5 osteoarthritis da kuma marasa lafiya na arthritis 5 na rheumatoid a lokacin arthroplasty (maye gurbin haɗin gwiwa), sa'an nan kuma sun kasance masu ladabi da kuma nazarin.
Pannus ya bayyana shi ta hanyar marubuta masu binciken kamar yadda "kwayoyin halittu masu zubar da ciki na microscopic da ke rufe duniyar". Dukkanin batutuwa da suka shafi nazarin suna da fannus da kuma fibrous. Gyaran daji na zamani ya haifar da kumburi, kuma an rage yawan sunadarai daga matasan samfurori da aka samu.
Rawancin ƙwayoyin chondrocyte bai kasance ba a cikin ƙwayar juji na osteoarthritis fiye da guttiyocin arthritis guringuntsi. Osteoarthritis synovial nama yana da ƙananan matakan proteoglycans fiye da rheumatoid arthritis synovial nama. Nau'i na nau'i na nau'i na nau'i na II sun kasance ƙananan a cikin gwargwadon ƙwayar osteoarthritis fiye da gwargwadon maganin arthritis. Mafi yawan matakan da ake kira interleukin-1-beta sun danganta da maganin arthritis na rheumatoid idan aka kwatanta da osteoarthritis pannus. Babban matakan TNF-alpha, IL8, da TIMP-1 sun danganta da dukkanin osteoarthritis da pheusal arthritis pannus.
Layin Ƙasa
An ƙaddara cewa rheumatoid arthritis da osteoarthritis pannus suna da irin wannan pro-inflammatory da anti-mai kumburi cytokine magana. Dalilin da yasa osteoarthritis pannus baya haifar da yaduwar iska kamar rheumatoid arthritis ba a sani ba.
Baya ga raguwa daga ɗakunan da ke faruwa a cikin osteoarthritis da arthritis na rheumatoid, pannus zai iya samuwa a wasu wurare, irin su a kan cornea, ko kuma a kan kwakwalwar zuciya. Yayinda pannus yayi girma, zai iya bayyana kyama-kamar.
Sources:
Rheumatoid Arthritis: Bincike a cikin MRI Features a cikin Musculoskeletal System. Hong Kong Journal of Radiology. Munk et al. 2002; 5: 63-68.
Osteoarthritis da rheumatoid arthritis pannus suna da irin halaye na dabi'un da suka dace kamar yadda ya kamata. Furuzawa-Carballeda J. et al. Rheumatology Clinical da gwaji. 2008 Yuli-Aug 26 (4): 554-60. http://www.ncbi.nlm.nih.gov/pubmed/18799084
RA Pathophysiology. Bayanan Arthritis. Johns Hopkins. Satumba 24, 2013.
http://www.hopkinsarthritis.org/arthritis-info/rheumatoid-arthritis/ra-pathophysiology-2/