Rashin ƙaddamar da shawara Daga Ɗaukaka Nazarin
Mutanen da ba su samar da isasshen hormone thyroid-kuma suna da haka hypothyroid -benefit daga levothyroxine , ko roba thyroid hormone. Hanyoyin hawan karo na da muhimmanci don dacewa da kyau. Ga mafi yawancin, aikin kula da hormone thyroid yana haifar da ƙananan illa, kuma karuwar yawan abu ne. Wasu ƙananan cututtuka na yau da kullum sun hada da lalacewa, ƙara yawan zuciya, flushing, sweating, da kuma tausayi.
Duk da haka, sababbin bincike sun hada da yin amfani da levothyroxine (Synthroid) tare da ciwon maganin thyroid . Ko da yake ban sha'awa, wannan karamin binciken ba ta da tabbas kuma yana buƙatar ƙarin bincike.
Bincike
A cikin wata Labari na Yuli na 2017 da aka buga a cikin Journal of Clinical Pharmacology , Hung da co-marubuta sun binciko ƙungiyar tsakanin levothyroxine da ciwon maganin thyroid ta amfani da bincike na jama'a. Ana nunawa daga bayanan da ke wakiltar mutane miliyan daya da mutane Taiwan, Magoya da abokan aiki sun gano kimanin 1285 wadanda suka karbi sanadin cutar ciwon maganin cutar thyroid a tsakanin Janairu 1, 2001, da Disamba 31, 2013.
Wadannan manya da ciwon daji na thyroid sun kasance tare da 3855 matasan ba tare da ciwon maganin thyroid (watau ƙungiyar kulawa) wadanda suke kama da shekaru, jima'i, da kuma likita. A cikin duka, akwai mutane 5140. Daga cikin waɗannan manya 5140, masu bincike sun gano mutum 70 da suka kamu da maganin hypothyroidism ta hanyar likitancin jini amma basu da tarihin tiyata.
Sakamakon aka gyara game da samun kudin shiga kowane wata, wuri na gefe, birni, amfani da taba, da cututtuka daban-daban. A cikin kididdigar, wadannan mutane 70 da hypothyroidism sun saba da juna a cikin hanyar da ta fi girma: thyroid cancer ganewar asali.
Hung da abokan aiki sun gano 37 manya da hypothyroidism wanda daga baya ya ci gaba da ci gaba da ciwon daji ciwon thyroid.
Sun kuma gano mutum 33 da ke dauke da hypothyroidism wadanda ba su ci gaba da ciwon ciwon maganin thyroid ba. Sai masu bincike suka kwatanta wadannan kungiyoyi biyu dangane da dalilai masu yawa, ciki har da yin amfani da levothyroxine na yau da kullum.
Masu bincike sun gano cewa tsofaffin ciwon daji na thyroid zai iya zama alamar cutar da jini, ciwon sukari, osteoporosis, da hyperlipidemia.
Mafi yawanci, Hung da abokan aiki sun gano cewa tsofaffi da hypothyroidism wanda a kai a kai ya dauki levothyroxine sun fi iya samar da ciwon ciwon thyroid cancer. Amfani da levothyroxine ba bisa ka'ida ba, ba a hade da ciwon maganin thyroid.
Hormone Hormone da Ciwon daji
Hanyoyin hawan karo na da muhimmanci don ci gaban al'ada, ci gaba, da kuma metabolism. Saboda ciwon daji yana nufin ɓangaren salon salula ba tare da rikitarwa ba, an yi tunanin cewa hormone na thyroid zai iya "karawa" ciwon daji. A cikin mutane, ƙananan bincike da iyakanceccen bincike suna goyon bayan tsammanin cewa hormone thyroid yana taimakawa wajen ciwon daji.
Hakanan, a cikin binciken da aka yi a shekarar 2009 da ake kira "Yourroid Function and Cancer Hazard: A Prolecting Population Population," Hellevik da masu marubuta sun sami hanyar haɗin kai tsakanin matakan da suka fi girma na hormone thyroid da wasu irin ciwon daji. Suka bi 29,691 Norwegians na shekaru 9. A farkon lokacin kallo, babu wani daga cikin wadannan mutanen da aka gano da cutar thyroid.
Masu bincike sun gano cewa mutanen da ke da matukar ƙananan mataki a lokacin binciken, wanda ke nuna damuwa game da hyperthyroidism, sun kasance mafi haɗari ga ƙwaƙwalwar ƙwayar cutar huhu da ciwon gurgu. (Babu wata dangantaka tsakanin hyperthyroidism da ciwon marigayi ko ciwon daji.)
Bugu da ƙari, Hellevik da abokan aiki sun gano cewa hypothyroidism ba nasaba da hadarin ciwon daji.
A wasu lokuta, wasu bincike sun nuna cewa mutanen da suka inganta hypothyroidism bayan an gano su tare da ciwon kai da wuyansa na tsawon lokaci. Bugu da ƙari kuma, mutanen da ke fama da ciwon daji da ke da ciwo na thyroid-kuma ta haka hypothyroidism-na iya rayuwa tsawon lokaci, ma.
A wasu kalmomi, wasu alamun bincike a yiwuwar cewa ƙananan ƙwayar jikinka zai iya zama kariya daga sakamakon ciwon daji. A cikin nazarin dabba, an nuna levothyroxine don ƙarfafa ciwon sukari da yada. Bugu da ƙari, hypothyroidism yana rage saurin ciwon sukari, ƙaddamar da ciwon tumo, da inganta rayuwa.
Kayan aiki
Gwargwadon gwargwadon gwargwadon ƙwayar wani hormone da ake kira hormone thyroid-stimulating hormone (TSH) . Gudanarwa na hormone thyroid a cikin hanyar levothyroxine yana ƙuntata matakan TSH ta hanyar maganin ra'ayoyin. Ba tare da TSH ba, thyroid ya yi hasarar manufar kuma ya yi shrin. Saboda wannan dalili, ana amfani da hormone thyroid a matsayin maganin jin dadi na thyroid nodules da goiters.
Da gaske, awancin jinin ka ya kamata ya zama ƙasa mai wuya. Duk da haka, tare da gwamnatin levothyroxine, an yi tsammanin cewa mafi yawan maganin hormone na thyroid na iya shawo kan wannan rikici da kuma juya rikici.
Kodayake tsarin ba shi da tabbacin, levothyroxine na iya zama tsaka-tsaki ko tsaka-tsakin tsaka-tsaki. A wasu kalmomi, levothyroxine na iya taka rawar kai tsaye ko kuma kai tsaye a cikin ƙwayar tumɓir. A cewar Hung da co-marubuta:
Har zuwa yau, babu alamun bincike akan yiwuwar abubuwan da ke cikin thyroxin-related carcinogenesis. Duk da haka, za'a iya bayyana wannan abu a hanyoyi biyu. Da farko, thyroxin zai yi aiki a matsayin mai kara ingantawa a cikin hanyoyi na al'ada ta carcinogenesis .... Na biyu, thyroxin a kan kansa iya ta da girma da ciwon daji cancer thyroid.
Menene ma'anar wannan?
An dauki shi kadai, wannan binciken binciken cewa yin amfani da levothyroxine yau da kullum zuwa ga ciwon maganin ciwon thyroid na nufin kaɗan. Wadannan sakamakon sun dogara ne akan binciken binciken da aka ware wanda ya kasance kadan. Bugu da ƙari, akwai wasu batutuwa tare da zane-zane.
Na farko, ƙananan mutanen da suke daukar levothyroxine don hypothyroidism suna ci gaba da ciwon ciwon ciwon thyroid ko wasu irin ciwon daji. Musamman, Magoya da abokan aiki sun gano cewa kashi 2.88 kawai na batutuwa da hypothyroidism sun ci gaba da ciwon ciwon ciwon thyroid. Bugu da ƙari, kawai kashi 0.86 na batutuwa ba tare da hypothyroidism ya ci gaba da ciwon ciwon ciwon thyroid.
Na biyu, wannan binciken shine kawai na farko don nuna wata ƙungiya tsakanin amfani da ciwon levothyroxine da ciwon maganin thyroid. Ka tuna cewa ƙungiya ba ta bambanta da wata hanyar. Masu binciken basu tabbatar da cewa levothyroxine yana sa ciwon maganin thyroid.
A cewar Hung da co-marubuta:
[Duk da yake binciken da aka bayar ya nuna cewa wata ƙungiya tsakanin ciwon maganin thyroid da amfani da thyroxin na yau da kullum, ana buƙatar ƙarin nazarin don kara ingantawa da kuma tabbatar da wadannan binciken .... Kodayake muhimmancin thyroxin a cikin ciwon ciwon ciwon ciwon thyroid ci gaba da bincike, likitoci zasu iya yin la'akari da wannan ƙungiyar lokacin da ake kula da marasa lafiya tare da hypothyroidism subclinical.
Masu marubuta sun amince da cewa abubuwan da suka gano shine ƙungiyoyi waɗanda suke buƙatar ɓarna a kan ƙaddamar da bincike. Wannan binciken yana da ƙananan kuma muna buƙatar girma mai girma samfurori don gaske nama daga kowane ƙungiya.
Abin sha'awa shine, marubuta sunyi shawarar dayawa cewa likitoci zasu iya kasancewa wannan ƙungiya a lokacin da suke tsara marasa lafiyar levothyroxine tare da hypothyroidism, ko rashin gamsuwa ta rashin ciwo. Wannan shawarar bai yiwu ba.
Na uku, ainihin tushen aikin bincike na iya zama mara kyau. Musamman, masu bincike ba su bambanta tsakanin daban-daban haddasa hypothyroidism. Harkar hypothyroidism, wanda zai iya buƙatar karin amfani da levothyroxine, ya bambanta da hypothyroidism mafi tsanani, wanda zai iya buƙatar yin amfani da levothyroxine na yau da kullum, kuma wannan bambanci mai ban mamaki zai iya ƙididdiga yawan yawan ciwon daji da aka gani tsakanin masu amfani da thyroxine. Ainihin, masu bincike sune apples and oranges.
Hudu, masu bincike sunyi amfani da bayanan inshora don bayyana yadda ake amfani dasu, kuma wanda bai dace ba.
Kalma Daga
Idan an bar shi ba tare da gurgunta ba, hypothyroidism na iya zama m da wahala. Mutane da ke da hypothyroidism suna fama da gajiya, da maƙarƙashiya, da ciki, da fata, da wadata. Levothyroxine magani ne mai mahimmanci ga hypothyroidism kuma zai iya inganta yanayin rayuwa. Mutane da yawa suna daukar levothyroxine a kowace rana ba tare da wata matsala ba.
Idan likitanku ya umarce ku da kullum levothyroxine don maganin hypothyroidism, kada ku damu da wannan magani da ke haifar da ciwon daji. Ga mafi yawancin mutane, amfanin levothyroxine ya fi iyakacin duk wani mummunan tasiri, ciki har da ciwon daji. Bugu da ƙari kuma, wannan binciken da ake haɗawa da ciwon levothyroxine a yau da kullum da ƙwayar ciwon thyroid yana da ƙananan kuma yana iya samun al'amura tare da zane. Daga karshe, haɗin da masu binciken suka ba da shawara ya buƙaci ƙarin bincike yayin da za'a iya yin la'akari da wasu ƙididdiga.
Bai kamata ku canza tsarin tsarin magani ba saboda tsoron ciwon maganin thyroid wanda ya dogara da wannan ƙananan ƙananan, watakila binciken mara kyau. Idan kuna shan levothyroxine a karkashin kulawar likitanku, don Allah ku biyo tare da wannan shirin kulawa. Duk wani canje-canje a tsarin shirinka dole ne a tattauna tare da likita.
Idan kun damu game da haɗin kai tsakanin levothyroxine da ciwon maganin thyroid - ko wani abu dabam, don wannan al'amari - don Allah tattauna wannan tare da likitanku ko likita mai kulawa . Ta hanyar yin tambayoyin, ba wai kawai kake magana da damuwa ba amma har ka koyi game da yanayinka. Gudanar da hankali shine muhimmin ɓangare na jiyya mai nasara.
> Sources
> Cantrell F. Babi na 150. Hutuwar Thyroid. A: Olson KR. eds. Cigaba da Drug Overdose, 6th New York, NY: McGraw-Hill; 2012.
> Hellevik, AI, et al. Ayyukan Thyroid da Ciwon Kankara: A Kusan Yawan Nazarin Mutane. Cancer Epidemiology, Biomarkers & Rigakafin. 2009; 18: 570-574.
> Hung, SH, Chung, SD, Lin, HC. Amfani da Thyroxin An Haɗa shi tare da Ƙarin Rashin Ciwon Cancer na Thyroid a Magunguna tare da Hypothyroidism. Jaridar Clinical Pharmacology. Yuli 19, 2017. (e-pub gaba da bugu)
> Stoll, SJ, et al. Canjin Hormone a Matsayi Bayan Thyroid Lobectomy. Tiyata. 2009; 146: 554-560.