Mene Ne Sabon Aiki na Cutar Ciwon Ƙwayar Ciwo?

Jiyya don ƙaddamar da ciwon gurguntaccen ciwon karuwanci

Yawancin abubuwa sun canza a maganin ciwon daji a cikin shekarun da suka gabata. Wannan shi ne ainihin gaskiya a wajen kula da ciwon ciwon gurguwar ƙwayar cutar prostate-metastatic (mCRPC). Wannan shine ciwon karuwanci wanda ya kasa samun magani na farko (tiyata, radiation da dai sauransu) kuma ya ci gaba da cinye magani na hormonal (maganin hawan maɓallin zub da jini ko castration).

Wannan kuma ya shafi marasa lafiya waɗanda ke gabatar da cutar ta hanyar ƙwayar cuta kuma sun kasa maganin hormonal. Kafin farkon amfani da chemotherapy ga waɗannan marasa lafiya na tsawon lokaci na tsawon lokaci kimanin watanni 8. Chemotherapy ya inganta a wannan amma ba curative ba.

Tun daga 2010 an sami sababbin sababbin jiyya ga marasa lafiya da mCRPC. Wadannan su ne bayanin taƙaitaccen sababbin jiyya.

1. Abiraterone Acetate (Zytiga) - Zytiga inhibits samar da sinadarin testosterone kuma ya rage matakan testosterone. Yawanci ana ba da prednisone. Zytiga an samo asali ne a cikin marasa lafiyar wadanda suka kasa yin docetaxel (chemotherapy) amma binciken da suka faru a baya sun nuna amfana a cikin marasa lafiya. Ɗaya daga cikin binciken ya nuna cewa raƙuman ci gaba na rai da rai (rPFS) ya kasance fiye da 16 watanni a cikin Abiraterone da rukunin prednisone a cikin watanni 8 a cikin rukunin kulawa.
2. Enzalutamide (Xtandi) - Da aka sani da sunan MDV3100 wannan magani ne mai ƙwayar maɓalli na asrogen na asali. Yana aiki duka a waje da ciki na tantanin halitta. An fara nuna shi a farkon likitocin marasa lafiya a bayan likitoci na MCRPC amma binciken ya nuna amfanar a cikin magungunan pre-chemo. Binciken na PREVAIL ya nuna cewa a matsakaicin lokaci, enzalutamide ya jinkirta buƙatar ƙwayar cutar ta kimanin watanni 17 (28 vs 11). Har ila yau, ya nuna cewa yin amfani da wannan magunguna ya ragu da kashi 81%.

1. Radium 223 Dichloride (Xofigo) - Ko da yake wannan allura ne ainihin irin radiation da ake kira haruffan haruffa. Wannan magani yana nufi don magance ciwon daji na prostate a kasusuwa. Kasusuwa tare da ciwon daji na prostate ya fi dacewa sha Xofigo. Radium sa'an nan kuma sake watsar da haruffan alpha, wanda yake da gajeren gajere. Manufar ita ce kashe kwayoyin cutar ciwon daji tare da ƙananan lalacewa ga kashi na al'ada. Wannan ya kamata a fi mayar da hankali fiye da strontium-89, wanda aka yi amfani dashi a baya. Nazarin da aka nuna sun nuna yawan ci gaba a marasa lafiya tare da mastPC da ƙananan metastasis.

1. Sipuleucel-T (Provenge) - Sipuleucel-T shine maganin alurar rigakafin ciwon maganin ciwon daji don ciwon daji na prostate. Ana nufin shi ne don marasa lafiya ko marasa lafiya marasa alamar nuna rashin lafiya a cikin mCRPC. Ana nuna shi ga kowane mai haƙuri kuma yana buƙatar gudunmawar jini. Ana cigaba da jinin a cikin laka sannan kuma sake sakewa a cikin mako. An bayar da magani sau uku a kan tsawon wata daya. Ita ce FDA ta amince da maganin alurar rigakafin ciwon daji (kamar yadda ya saba da rigakafin rigakafi). An cigaba da rayuwa ta rayuwa ta hanyar amfani da Provenge a cikin bayyanar cututtuka ko marasa lafiya marasa lafiya na MCRPC.

Tambayoyi don fatan za a bayyana a nan gaba su ne yadda za a mafi kyau jerin wadannan sababbin jiyya? Lokacin da mai ciwo ya rasa cikas, wane magani ya kamata a fara amfani dashi ko ya kamata a fara samo chemo? Wanne magani ya ba da mafi kyawun darajar? Shin ana amfani da waɗannan magunguna ne kadai ko a hade? Duk da yake akwai tambayoyin da yawa da suka fice a cikin kwanan nan kwanan nan ga magungunan prostate prostatarium zai shawo kan marasa lafiya da yawa.

_Sources

_{Rathkopf DE, Smith MR, De Bono JS, et al. Binciken rikice-rikice na zamani (IA) na COU-AA-302, nazarin nazarin nazarin acetate na Abiraterone (AA) a wani lokaci na marasa lafiya (pts) tare da ciwon ƙwayar cutar ciwon gurguntacciyar cututtuka (MCRPC) ba tare da maganin rigakafi ba. J Jara Incol. 2013; 31 (wadata 6, abstr 5).}

_{Beer TM et. al. Enzalutamide a cikin maza tare da cutar shan ƙwayar prostate cutar ƙyamar cuta (mCRPC): Sakamakon binciken na watanni 3 na PREVAIL. J Jumma'a 32, 2014 (samfurin 4; abstr LBA1 ^).}

_{Parker C et al. Alpha Emitter Radium-223 da Rayuwa a Ciwon Ƙwayar Ciwon Ƙari. N Engl J Med. 2013; 369: 213.}

_{Longo DL (Yuli 2010). "Sabbin hanyoyin kwantar da cutar don ciwon ciwon gurguwar karuwa". N. Engl. J. Med. 363 (5): 479-81.}