Kwararrun cututtuka na intraperitoneal shine hanya don bada magani ga ilimin chemotherapy don ciwon daji na ovarian kai tsaye a cikin rami na ciki. Yayinda yawancin kwayoyin cutar shan kwayar cutar ne cikin kwayar cutar, da kuma sababbin hanyoyin nazarin kwayoyin halitta ko kuma maganin kwantar da hankulan su ne mabambanci, hanyar da za a iya amfani da ita wajen samar da chemotherapy yana daya daga cikin maganin farko na mata da mataki na III .
Nazari mai mahimmanci
A shekara ta 2006, an fitar da sakamakon GOG 172 na Gynecologic Oncology Group a cikin New England Journal of Medicine. A cikin wannan binciken, mata sun cancanci magani idan suna da ciwon ciwon daji na ovarian ko ciwon daji na asibiti na farko da kuma idan suna da tiyata mai mahimmanci (ma'ana cewa babu sauran kwayoyin tumo da suka rage fiye da 1 cm a baya bayan tiyata).
An yi watsi da gwaji, wanda ke nufin cewa an sanya marasa lafiya zuwa ƙungiyar kulawa ta hanyar yin amfani da komputa ta tsabar kudi. Daga cikin wadannan matan 415 a cikin binciken, rabi ya karbi maganin ilimin likitanci na intravenous tare da cisplatin da paclitaxel ( Taxol ). Sauran rabi sun karbi irin wannan kwayoyi, amma a cikin haɗuwa da intravenous (paclitaxel) da kuma intraperitoneal (cisplatin da paclitaxel) bayarwa.
Wannan ba sauki ba ne don ɗauka, kuma sakamakon binciken ya tabbatar da hakan. Kusan kashi 42 cikin dari na matan a cikin ƙungiyar intraperitoneal sun sami karbar sakonni shida na intraperitoneal chemotherapy.
90% na mata a cikin rukuni na intravenous sun karbi dukkanin haɗari shida. Matan da suka karbi shan magani sunadarai sun fi tsanani ko damuwa da rai, jin zafi, jinin jini, da kuma cututtuka na kwayoyin halitta. Har ila yau, mahimmanci a lura cewa, mata tara sun mutu a lokacin chemotherapy - hudu a cikin rukuni na intravenous da biyar a cikin ƙungiyar intraperitoneal.
Kisan ya kasance saboda kamuwa da cuta.
Amfanin Rayuwa
Wannan nazarin binciken na 2006 ya ba da labarin, duk da rashin guba da magani, saboda sakamakon rayuwa. Duk da cewa kawai kashi 42 cikin 100 na mata a cikin rukuni na intraperitoneal sun iya karbar dukkanin motsa jiki na shida, rayuwar tsira (free survival) kafin ciwon daji ya cigaba) ya kasance tsawon watanni 5 da 1 zuwa ga ƙungiyar chemotherapy na intraperitoneal. Ko da mafi ban sha'awa shi ne duk abinda ke faruwa na rayuwa. Matan da suka karbi shan magani a cikin kwayar cutar sunyi kusan kusan watanni 16 fiye da matan da suka karbi chemotherapy kadai - 65.6 watanni idan aka kwatanta da watanni 49.7.
Bisa la'akari da sakamakon wannan binciken, da kuma a wasu lokuta na uku na jarrabawa uku, Cibiyar Cancer ta Kasa ta bayar da wata sanarwa mai mahimmanci na Clinical wanda ya bada shawarar cewa an yi amfani da ƙwayar cutar shan magani ga magungunan marasa lafiya.
Abubuwan Ta'ida
Samun shan magani na kwayar cutar ba don kowa ba ne tare da ciwon daji na ovarian, duk da haka. Ka tuna, bisa ga binciken da aka fi sani da shi, mun sani kawai yana amfana da matan da ke fama da cutar III wanda kuma sunyi aikin tiyata mai kyau (babu ƙwayar ƙwayar ƙwayar jiki fiye da 1 cm a bayan bayan tiyata).
Domin yin amfani da cututtuka na intraperitoneal, dole ne a sanya murfin intraperitoneal (tashar jiragen ruwa) a cikin bango na ciki daga masanin ilimin ilmin likitan kwalliyar gynecologic. Idan ba a sanya shi a lokacin farawa na farko ba, za'a iya sanya shi a baya, a cikin wata hanya dabam dabam ta hanyar likitan ilmin likitancin mutum ko kuma ta hanyar mai jarida. Nurses da ke kula da ilimin ilimin chemotherapy ta wannan tashar jiragen ruwa dole ne su kasance masu kwarewa da dadi tare da tsarin. Kwanƙiri na iya ƙyale ko an hana shi. Gudanar da sakamakon da ake ciki ya buƙaci likita mai ilimin likita ko likita mai ilimin likitancin mutum wanda ya kware irin wannan magani.
A Bi Up
Wani binciken da Dokta Wright da abokan aikinsa suka yi kwanan nan, wanda aka wallafa a Jaridar Clinical Oncology, ya nuna cewa ba duk mata masu cancanta don shan magani na jijiyoyin cutar ba. Ƙungiyarta ta yi nazari game da mata 823 wadanda ke da matakan yara na III ko ƙwayar fallopian ko ƙananan ciwon peritoneal. Wadannan mata sun bi da su a manyan cibiyoyin ciwon ciwon daji guda shida da ke cikin Cibiyoyin Ƙwayar Cutar Ƙasar, ciki har da City of Hope, Dana-Farber / Brigham da Mata, Fox Chase, Jami'ar Jihar Ohio, Jami'ar Texas MD Anderson Cancer Center, da kuma Jami'ar Michigan.
Kungiyar Wright ta gano cewa kasa da kashi 50 cikin 100 na matan da suka cancanci karbar cutar shan magani a ciki sun sami shi. Har ila yau, binciken su ya tabbatar da cewa matan da suka karbi shan magani a cikin jiki sun rayu fiye da waɗanda suka karbi maganin ƙwayar cuta kawai.
Maganar Take-Home
Kwayar cutar shan magani na ciwon magungunan ovarian ko ciwon daji na ciwon peritoneal yana da muhimmanci wajen magance wadannan cututtuka, tare da inganta yanayin rayuwa don marasa lafiya da zasu iya samun wannan farfadowa. Duk da haka, zai iya zama mummunan magani tare da cututtukan sakamako mafi muni fiye da ilimin likitancin magani na intravenous. Idan har yanzu an fara bincikar ku tare da ci gaba da ciwon ciwon koyarwar ovarian ko ciwon daji na farko, ya kamata ku tattauna da likitan ku game da ko wannan tsarin ya dace muku.
> Sources:
> Armstrong DK, Bundy B, Wenzel L, et al. Na ci gaba da cisplatin da paclitaxel a ciwon daji na ovarian. N Engl J Med . 2006; 354 (1): 34-43.
> Sanarwar Harkokin Gudanarwa ta NCI , 2006. https://ctep.cancer.gov/highlights/docs/clin_annc_010506.pdf.
> Wright AA, Cronin A, Milne DE, et al. Amfani da tasiri na cututtuka na intraperitoneal don maganin ciwon daji na ovarian. J Jara Incol . 2015 Agusta 3. Epub gaban bugu.