Duk da yake ba a nuna alamun cutar polycystic ovary (PCOS) ba, metformin ita ce mafi yawan magani wanda aka tsara don taimaka wa mata da ke fama da yanayin. Sakamakon sabon bincike yana nuna dangantaka tsakanin dogon metformin da kuma bitamin B12, duk da haka mafi yawan masu kula da kiwon lafiya sun yi watsi da matsayin B12 a masu amfani da metformin. Rashin bitamin B12 zai iya haifar da mummunar lalacewa da tsararru ta jiki.
Ga abin da zan sani game da bitamin B12 idan ka dauki metformin.
Menene Metformin?
Metformin yana aiki ne a matsayin insulin-sensitizer don rage yawan samar da glucose kuma an ba da izini ga mutane masu ciwon sukari na 2 saboda wannan dalili. Sauran sunaye na metformin sun hada da glucophage, XR, glucophage, glumetza, da kuma kayan aiki.
Metformin yana rage glucose da jini da matakan insulin a hanyoyi da dama: Yana hana ciwon hawan glucose, haɓaka hankalin hanta, tsoka, mai, da kuma kwayoyin jikinsu da insulin jikinka yana sa, kuma yana rage karfin carbohydrates da ka ci.
An nuna cewa Metformin ya inganta insulin da matakan lipid (cholesterol) a cikin mata tare da PCOS kuma zai iya taimaka wajen inganta yaduwar halitta.
Amfani da Metformin da kuma Bambance-Bambance B12
Ciwon Rigakafin Ciwon Abun Ciwon Abun Ciwon Abun Hutar Ciwon Nazarin (DDPOS) yana wakiltar daya daga cikin mafi yawan binciken da aka fi sani da magani na metformin. Wani sabon bincike na DDPOS da aka wallafa a cikin Journal of Clinical Endocrinology da Metabolism ya dubi matsayin B12 na mutane da wadanda ke dauke da likitanci wadanda suka dauki Metformin miliyon 850 sau biyu kuma idan aka gwada su zuwa ga wadanda ke daukar wuri.
An kiyasta matakan Vitamin B12 a shekaru 5 da 13.
Sakamako daga DDPOS sun nuna cewa amfani da ƙwayar metformin na dogon lokaci ya ƙara haɗari ga matakan bitamin B12. A shekaru 5, kashi 5.2 na masu amfani da metformin suna da ƙwayar magani B12. A shekaru 13, kashi 9.2 cikin dari na masu amfani da metformin basu da matakan B12. Lokacin da ake sarrafawa da shekaru, da jima'i, da kuma BMI, akwai kashi 13 cikin 100 na yawan ƙimar B12 na kowace shekara na duka tsarin metformin.
An yi imani da cewa metformin zai iya rinjayar shayar bitamin B12 a cikin ileum na ƙananan hanji. Ba wai kawai kwayoyin Bamin B12 sun shafi ilimin DDPOS ba, amma matakan homocysteine, alama ce ta cututtukan zuciya, sun karu a tsawon lokaci a masu amfani da metformin.
Wasu binciken sun nuna cewa metformin zai iya rinjayar matakan bitamin B12 a cikin ƙananan watanni uku na amfani. Binciken da aka tsara na yau da kullum da kuma nazari-bincike ya duba mutane masu ciwon sukari da mata 2 tare da PCOS wadanda suka dauki metformin. Sakamakon su ya samo mafi girma ga tsarin metformin, yawancin mutane sun kasance a cikin bitamin B12 kuma metformin din rage matakan bitamin B12 a duka tsawon lokaci (≥3 shekaru) da gajeren lokaci (<3 shekaru).
Matsakaicin matsakaici na metformin ga mata tare da PCOS ita ce 1,500 MG zuwa 2,000 mg kowace rana. Mafi yawan mata da PCOS sunyi amfani da ƙwayar metformin don yin amfani da dogon lokaci, ƙara yawan haɗari ga raunin bitamin B12.
Muhimmancin Vitamin B12
Gishiri mai narkewa mai ruwa, B12 yana da mahimmanci don hawan jijiya, aiki na tunanin mutum, DNA kira, da kuma tsarin jini na jini. Vitamin B12 an samo shi a cikin samfurori na dabba. Wadanda suka bi kayan abinci na vegan dole ne su kara yawan abincin su tare da bitamin B12. Gwargwadon shawarar yau da kullum na bitamin B12 ga mafi yawan manya shine 2.4 mcg.
Kwayoyin cututtuka na raunin B12 sun haɗa da wasu nau'o'in anemia, neuropathy (cututtukan hauka), wahala mai tsanani, ƙwaƙwalwar ƙwaƙwalwar ajiya, rikice-rikice, sauyawa yanayi har ma da lalacewa.
Wani rashi na bitamin B12 yana da matukar tsanani, yana tasiri yanayi da makamashi kuma zai iya haifar da neuropathy na dindindin. Wani lokaci shan wani multivitamin wanda yana da bitamin B12 zai iya haifar da rashin raguwa a masu amfani da metformin. Duk wanda ya dauki metformin ya kamata ya yi nazari akan bitamin B12 a kowace shekara kuma ya kari abincin su yadda ya kamata a gare su. Methylcobalamin irin bitamin B12 a cikin nau'i mai zurfi (ƙarƙashin harshen) mafi kyau yafi ji dadin jiki.
Ta Yaya Binciken Bincike na Bikin Bidiyo na Bidiyo B12?
Samfurin jini zai iya tantance matakan bitamin B12. An ba da shawara cewa ana amfani da labaran labaran rubutu ga al'ada B12 matakan da yawa kuma cewa bayyanar cututtuka na rashi zai iya nunawa a matakan a karkashin 400 pg / ml.
Binciken methylmalonic acid (MMA) wani jarrabawar gwaji ne wanda zai iya kwatanta matsayin bitamin B12 da gaske.
Lissafin ƙasa: Idan ka ɗauki metformin, ka tambayi likita don bincika bitamin B12 matakan kowace shekara kuma ka kara yawan abincinka tare da bitamin B12 don hana rikitarwa na rashi.
Sources:
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