Idan kun kasance mace mai ƙananan ko ƙananan matakan da ake yi da hormone thyroetpin (wanda aka sani da thyroid stimulating hormone , ko TSH) kana da haɗarin ƙwayar cutar Alzheimer . An bayar da rahoton a cikin jaridar likita, Cibiyar Nazarin Harkokin Ciki .
Binciken
A cikin babban binciken, wanda aka gudanar a matsayin Framingham Nazarin, yawancin marasa lafiya 2,000 an kimantawa a lokaci-lokaci don cin zarafi a tsawon tsawon shekaru goma.
Har ila yau kungiyar ta biyo bayan kusan shekara 13. A lokacin wannan lokacin, 209 na marasa lafiya sunyi nazarin cutar Alzheimer. A cikin mata, matakan TSH sun danganta da cutar Alzheimer. A gaskiya ma, ga mata masu tSH a kasa da 1.0 ko fiye da 2.1, akwai hadari fiye da sau biyu na cutar Alzheimer. Abin sha'awa, babu dangantaka irin wannan da aka gani a cikin maza.
Masu bincike ba su san ko canje-canje ga thyroid aiki da TSH suna faruwa kafin ko bayan da farko da ganewar asali na cutar Alzheimer. Har ila yau, basu san ilimin kimiyya ko na ilmin halitta ba a baya da dangantaka. Suna yin haka, duk da haka, suna ba da shawarar cewa za a gudanar da bincike don gudanar da bincike don sanin ko akwai wani tasiri ga magani ko rigakafi.
Wata kila mafi mahimmancin ganowa, shine, sakamakon shine iri ɗaya, ko marasa lafiya sun kamu da maganin thyroid kuma suna shan magani na maye gurbin karoid ko a'a.
Ayyukan motsa jiki sun bayyana matsayin matakin TSH.
Duk da yake hyperthyroidism mai tsabta ko hypothyroidism na iya haifar da matsalolin da ke da hankali, da matsaloli tare da ƙwaƙwalwar ajiya, tunani, da kuma ilmantarwa, waɗannan cututtuka ana ganin sun kasance masu juyayi tare da maganin maganin karoid. Wannan binciken, duk da haka, ya kalubalanci al'adun gargajiya cewa matsalolin thyroid sune dalilin da ya sa rashin tausayi.
Maimakon haka, binciken binciken ya nuna cewa rashin daidaituwa a cikin aikin takaicinka na iya zama maɗaukaka matsala ga hadarin bunkasa cutar Alzheimer.
Daya daga cikin marubucin binciken, Dr. Zaldy Tan, ya gaya wa Medscape:
Ya kasance mai ban sha'awa a gano cewa duk wani mummunan ƙananan matakan da ke cikin alaƙa da cutar Alzheimer. Koda yake kwakwalwa yana ƙoƙari ya kula da matakan ƙwayar jikinka a wani wuri mai sauƙi wanda zai iya ɗauka cewa don yin aiki da kyau, dole ne a kiyaye shi a cikin wannan tashar. zuwa ƙasa ko sama da ba abu mai kyau ba ne.
Ba a fili ba ko matakan TSH suna haifar da Alzheimer, kare kariya daga Alzheimer, ko kuma cutar Alzheimer ta shafi TSH. Binciken ya kasance tsinkaya kuma bai kimanta ka'ida ba. Masana sunyi la'akari da cewa cutar mai cutar Alzheimer zai iya lalacewa ta hanyar cutar kwakwalwa, ko kuma maganin rashin lafiya na hormone wanda zai iya taimakawa wajen bunkasa cutar Alzheimer.
Ɗaya daga cikin maganganu masu ban sha'awa da masu rubutun binciken suka dubi muhimmancin aikin hormone na thyroid yana takawa wajen yin magana da wani jinsin da ake kira amyloid precursor protein (APP), wanda ke da tasiri a cikin Alzheimer's. Yana yiwuwa yiwuwar maganin hormone na thyroid zai iya haifar da matsaloli tare da tsari na APP, don haka kara haɗarin Alzheimer's.
Karin bincike akan dangantaka tsakanin thyroid, matakin TSH, da kuma cutar Alzheimer. Irin wannan bincike zai iya, duk da haka, ya ƙare samar da dalilai masu kyau don ƙwararrun likita don ƙaddamar da taƙaitacciyar TSS.
Wannan fitowar ta kasance rikici. A shekara ta 2002, Ƙungiyar Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru ta Amirka (AACE) ta ba da umarnin taƙaita tashar TSH daga yawancin amfani da 0.5 zuwa 5.0 mIU / L, zuwa iyakaccen digiri na 0.3 zuwa 3.0, tare da Ƙungiyar Ƙungiyar Clinical Biochemistry ta ba da shawara da mahimmanci. iyaka na 2.5. Yayinda wasu likitoci da masu binciken likita suka nemi shawara, AACE ya watsar da wannan shawarwari, kuma dakunan gwaje-gwaje da likitoci sun kimanta kimanin kwayoyin cutar ta maganin jinin kuɗin jini kamar yadda ya kamata a cikin tsofaffi 0.5 zuwa 5.0.
Kalma daga
Amma a halin yanzu, wannan binciken yana bada ƙarin shaida don yin jayayya cewa, ga marasa lafiya masu karɓar maganin maganin karoid, ƙaddamar da samfurin don ƙimar TSH mafi kyau duka yayin da magani zai kasance tsakanin 1.0 zuwa 2.0, sai dai idan wasu abubuwan da ke gaggawa yanzu suna da hannu. (Alal misali, wasu marasa lafiya na thyroid ciwon daji suna kiyayewa a kan maganin maganin maganin thyroid, da kiyaye ƙwayar TSH sosai, ko kuma wani lokaci an matsa shi zuwa matakan kusa da 0, a matsayin hanyar da za ta hana yaduwar cutar ciwon thyroid.
> Source:
> Tan, Zaldy et. al. "Ayyukan Thyroid da Hadarin Alzheimer cuta: Nazarin Framingham." Cibiyar Nazari ta Magunguna , 2008; 168 (14): 1514-1520.