Ƙara koyo game da nau'in nau'in nau'in VT 400 na Paenibacillus
A lokacin rani na shekara ta 2016, a taron shekara-shekara na Ƙungiyar Jama'ar Amirka don Microbiology, masana kimiyya sun taru don raba da tattauna abubuwan da suka shafi duniya da kwayoyin cuta da lafiyar mutum.
Daga cikin abubuwan da aka gano, wata kungiya ta ruwaito akan dukan kwayoyin halitta, ko jinsin kwayoyin halitta, don kwayoyin da ake kira Paenibacillus nau'in nau'in VT 400 (PVT400). Wadannan kwayoyin sun kasance an gano su a cikin kwayar likitancin yara tare da kwayar cutar ciwon sankarar lymphoblastic mai tsanani (ALL).
Bayanin cikakken bayani daga wannan nazarin da kuma na gaba zai taimaka wa masana kimiyya su ko ko waɗannan kwayoyin zasuyi tasiri a cutar cututtukan mutane, musamman ma mutanen da ke dauke da cutar sankarar bargo wanda ke haifar da ciwon huhu ko jini.
Ciwon huhu a Mutum da Ciwon Cutar
Ciwon huhu shine babban dalilin mutuwar marasa lafiya da marasa lafiya tare da neutropenia, musamman wadanda ke da cutar sankarar bargo. Neutropenia ne ƙananan ƙidodin neutrophils a cikin tsubar jini-neutrophils su ne kwayoyin fararen fata wadanda suke da muhimmanci wajen taimaka wa jiki don yaki da kamuwa da cuta .
Kwayoyin cututtuka na ƙananan numfashi suna da kyau a cikin marasa lafiya, tare da wasu rahotanni da ke nuna cewa kashi 13 zuwa 31 na marasa lafiya na cutar sankarar bargo suna karɓar ilimin chemotherapy kuma kimanin kashi 80 cikin hamsin masu karɓa na kwayoyin hematopoietic za su fuskanci akalla daya cikin ɓangare na ciwon huhu.
Kwayoyin cuta neutropenic sune cututtuka masu rai da rai. A irin wannan yanayin, likitoci sun fara maganin kwayoyin cutar nan da nan, ba tare da jiran sakamakon binciken labaran don tabbatarwa da kuma bayanin irin kamuwa da cuta na kwayan cuta-saboda yana da muhimmanci a fara farawa a lokaci daya, don rage haɗarin cewa mai haƙuri zai ci gaba da kamuwa da cutar.
A gaskiya ma, an yi amfani da maganin rigakafi a wasu yanayi, wanda aka bayyana a kasa.
Rigar kwanan nan a cikin gudanar da cutar ciwon neutropenic suna sa zuciya ga sakamako mafi kyau. Ƙungiyoyin kiwon lafiya da yawa sun ba da ka'idodin da aka tsara don maganin kwayoyin cutar da ake zaton rashin ciwon neutropenic.
Kuma akwai yiwuwar sababbin jami'o'in da ke inganta maganganun jikin su ga kamuwa da cuta zai iya inganta aikin maganin rigakafi.
Ana mayar da hankali ga marasa lafiya a cikin marasa lafiya tare da Neutropenia
Sharuɗɗa daga Cibiyar Nazarin Kwayoyin Harkokin Kwayoyin Nahiyar Amirka (ASCO) ta ba da shawarar cewa likitoci su yi ƙoƙari su hana kamuwa da cuta a cikin masu fama da tsaka tsaki amma ba zazzabi ba. An shawarci magani na maganin antibacterial da kuma maganin marasa lafiya idan ana tsammanin tsaka-tsakin tsaka-tsaki ya kasance a ƙasa 100 / μL fiye da kwana bakwai. Jagoran ya nuna cewa wakilin da aka fi so ga maganin rigakafi na antibacterial abu ne mai mahimmanci, yayin da wannan don maganin rashin lafiya ya zama triazole.
Magunguna da neutropenia suna mai saukin kamuwa da nau'o'in pathogens fiye da takwarorinsu. Zai iya taimaka wa likitoci suyi la'akari da inda kwayoyin suka fito daga tsinkayar abin da kwayoyin rigakafi zasu iya tsayayya da shi, sabili da haka wane labarun zasu iya zama mafi tasiri.
Paenibacillus Species
A wannan karshen, masana kimiyya suna nazarin PVT400, sabon kwayoyin cutar daga cutar cutar sankarar bargo, wani mamba na Paenibacillus genus-iyali na kwayoyin kwayoyin halitta. Dabbobi daban-daban a wannan rukuni sun ware daga ƙasa, ruwa, tsire-tsire, madara, da sauran shafuka.
Duk da haka, jinsin Paenibacillus ba san sanadiyar cututtukan mutum ba. .. har sai rahotanni na baya-bayan nan sun nuna yiwuwar shigar da nau'o'in Paenibacillus daban-daban a cikin cututtukan mutane.
Bayan da aka ware PVT 400 daga cutar na likitan yara tare da cutar kankarar lymphoblastic mai tsanani , binciken farko ya nuna wasu kamanni da waɗannan nau'o'i tare da jinsunan amylolyticus, wanda aka samo a cikin tsutsoran kwari na tashi; duk da haka, har yanzu, har yanzu yana da gaskiya cewa ba a gano P. amylolyticus a cikin mutane ba, kuma cigaban nazarin ya nuna bambanci tsakanin kwayoyin cuta-VT 400 da aka gano a cikin ciwon daji da sauransu.
amylolyticus damuwa.
Don haka, lokacin da masu binciken suka bincika dukkanin kwayoyin VT 400, akwai wasu abubuwan da ke sha'awa. Ya na da kwayoyin halittar da ke kunshe da hanyoyin juriya zuwa kwayoyi masu jiyyar cutar, kamar tunicamycin da bleomycin. Har ila yau, sun gano kwayoyin kwayoyin cutar kwayar cutar da ke hade da maganin maganin maganin kwayoyi, da kwayoyin halittar da ke dauke da juriya ga maganin rigakafi, ciki har da vancomycin, fosmidomycin, tetracycline da magungunan penicillin, ko beta-lactams.
Mawallafin wannan nazarin kwayar halitta sun lura cewa dukkanin abin da Paenibacillus ya rubuta shi ne. nauyin VT 400 zai taimaka wajen ƙayyade muhimmancin nau'in Paenibacillus a cikin cututtuka na mutum kuma ya samar da hankali ga kwayoyin halitta da ke zaune a marasa lafiya da cutar jini.
Sources:
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