Tsara Ayyukan Mawallafin Myelin Tsarin Ƙari ne a MS Far
Cigaban hanyoyin yau da kullum ga ƙwayoyin sclerosis da yawa ke sa ido ga tsarin rigakafin mutum. Duk da yake an gano su don rage yawan lambar da aka samu na MS, babu sauran magani ga MS, saboda haka mutane zasu ci gaba da zama ƙwayar cuta yayin da cutar ta ci gaba.
Amma yanzu masana suna nazarin hanyoyin kwantar da hankulan da ke cike da maganin da ke dauke da kwayar cutar da ke cikin MS.
Bari mu dubi muhimmancin myelin a cikin ƙananan sclerosis, da kuma yadda yadda za'a gyara shi zai iya mayar da aikin neuro kuma ya rage gudu ko kuma ya dakatar da MS a cikin waƙoƙinsa.
Ayyukan Myelin a Multiple Sclerosis
A cikin mutum mai lafiya, kwayoyin jikinsu suna aika da kwari ga juna tare da filafin filaye da ke haɗe da jikin kwayar jijiya. Wadannan ƙananan fuskoki suna kiransa axons kuma an rufe su da wani kullun mai suna "myelin". Yin hidima a matsayin murfin mai karewa ko mai laushi, myelin yana ba da damar ƙwayar jiki don tafiyar da sauri da kuma yadda ya kamata.
A cikin ƙwayar sclerosis , kwayoyin cutar ta jiki na mutum ya kai hari ga myelin (da kuma maɗaukaki a cikin kwakwalwa da / ko igiya. Rikicin hare-haren da ake yi a kan myelin ƙarshe yana haifar da ƙwanƙwasawa. Yayinda ake dawwamamina mai yaduwar cutar, ba za a iya kwantar da hanzarin motsa jiki ba daidai ba-suna tafiya ne a hankali ko a'a. A ƙarshe, magunguna sunyi rashin ƙarfi (rasa ikon yin aiki) saboda sakamakon asarar myelin, wanda ya haifar da mutuwar kwayar halitta.
Dangane da inda aka kai hari a cikin sakon ƙwaƙwalwar ƙaƙƙarfan ƙwayar cuta, ana nuna alamun bayyanar cututtuka kamar abubuwan da ke tattare da rayuka, matsalolin hangen nesa, ƙari, da matsaloli masu mafitsara. Wannan shine dalilin da yasa bayyanar cututtuka ta MS sun bambanta daga mutum ɗaya zuwa wani, kamar yadda wuri na hare-haren na myelin ya bambanta a cikin tsarin kulawa na tsakiya.
Bugu da ƙari, ga shafukan yanar gizo masu rikitarwa a cikin kwakwalwa da na kashin baya, lokaci na wadannan hare-haren yana da rashin tabbas-ko da yake, masana sun gano mawuyacin hali kamar damuwa ko lokacin bazara.
Sauya Myelin: Mataki na gaba a MS Far
Duk da yake maganin cututtuka na zamani na MS ya mayar da hankalin yadda za a hana tsarin rigakafi na mutum daga tayar da myelin, yanzu masana kimiyya suna duban yadda za a gyara gyaran salula a yayin da lalacewar ta lalace. Fata shi ne cewa idan an sake gyara myelin, za'a iya dawo da aikin neuro na mutum, kuma MS na iya dakatar da ci gaba (ko a kalla jinkirin).
Gaskiyar ita ce, wasu binciken sun rigaya nuna cewa kiyaye da sake dawo da maganin da ke kewaye da shi yana iya kara yawan rayukan kwayar cutar. Tun da rashin lafiyar mutum akan MS ya danganta da mataki na mutuwar kwayar cutar ta jiki, ta hanyar gyara myelin da kare kodoyin sutura, masana sunyi fatan za mu iya dakatar da ci gaban rashin lafiya a cikin mutane tare da MS.
Cibiyar Nazarin Harkokin Waje na Fasaha a kan Maɓallin Iyali
Binciken da ake yi game da gyaran aiki da gyaran myelin a cikin sclerosis mai yawa yana da wuri sosai. Duk da haka, yana da ban sha'awa da kuma yiwuwar mataki na kusa da kawo karshen MS sau daya da kuma duka.
Ɗaya daga cikin ƙananan binciken, na II na Jami'ar California San Francisco an gabatar da shi a Cibiyar Nazarin Harkokin Kasa ta Amirka. A cikin wannan binciken, an gwada magungunan rashin lafiyar jiki da ake kira clemastine don ganin ko zai iya inganta gyaran gyaran na myelin a cikin kwakwalwar mutane da MS.
A cikin wannan binciken, an baiwa mutane 50 da MS da kuma ciwon suturar ƙwayoyi ko dai a cikin bakin sau biyu a rana ko kwayar wuribo don kwanaki 150. Bayan 90 na waɗannan kwanaki 150, masu halartar taron sun sauya hanyoyin kwantar da hankula, ma'ana wadanda suka karbi clemastine sun sami wuribo da farko.
Masu halartar sunyi amfani da kayan gani na gani, wanda yaduwar siginar siginar daga ido daga cikin ido ta hanyar jijiyar jiki ga tsarin jiki mai gani - yankin kwakwalwa wanda ke tafiyar da hotuna, ko a wasu kalmomi, ya canza abinda kake gani a cikin ainihin hoto.
Sakamakon ya nuna cewa jinkirta a cikin kullun gani mai hankali ya rage da 1.9 milliseconds da idanu don lokacin da ake kula da mutane tare da clemastine. Wannan raguwa a cikin jinkirin bazza'in jinkiri ya nuna cewa gyaran gyare-gyare na myelin yana faruwa tare da hanya na sigina na jijiya.
Ɗaya daga cikin mahimman bayani na binciken shine cewa kashi na clemastine ya fi girma da yawancin da aka ba da shawarar, don haka ba abin mamaki bane, shi ya sa wasu gajiya a cikin mahalarta.
Magunguna masu maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin jinƙai
Sauran karatun farko suna tattara marasa lafiya ko a halin yanzu suna aiki game da magunguna waɗanda zasu iya taimakawa wajen gyaran gyare-gyaren myelin da kuma kare kwayoyin jiki a cikin tsarin kulawa na tsakiya.
Alal misali, gwaje-gwajen Phase 1 (da wuri) suna gudana ga duka Olesoxime da Guananbenz.
Guanabenz (magani ne da FDA ta amince don magance cutar hawan jini) ya samo a cikin nazarin dabba don kara yawan rayuka wanda ke samar da myelin (wanda ake kira oligodendrocytes). An kuma samo shi don rage yawan yawan kwayoyin da ke tattare a cikin kwakwalwa da kashin baya.
Wani magani da ake kira Olesoxime , wadda aka samo asali don magance amyotrophic lakaran sclerosis , an samo su duka biyu don inganta matuƙar kwayoyin halitta na kirji a cikin kwakwalwa da kuma kashin baya da kuma inganta haɓakawa.
Quetiapine wani tsattsauran ra'ayi ne wanda aka samo don samun dukiya a cikin samfurin dabba na MS. An yi imani don karewa da kuma ƙarfafa ci gaban kwayoyin jijiyoyin da ke sa myelin (oligodendrocytes) da kuma hana kwayoyin jikinsu da ke cikin hadarin na myelin a cikin MS.
Bugu da ƙari da yiwuwar sake gyara myelin a cikin mutane tare da MS, a matsayin magungunan ƙwayar cuta, yana iya samun ƙarin amfani na magance matsalar yanayi da rashin barci a cikin MS. Binciken binciken bincike a cikin duka MS da MS MS mai ci gaba yana gudana.
Kalma Daga
Ma'anar cewa miyagun ƙwayoyi zai iya inganta hanyar gyaran gyaran myelin a cikin tsarin kulawa na tsakiya yana da ban sha'awa. Yana nuna cewa kwakwalwa na iya gyara kansa, maido da aikin da ba a taɓa ba shi ba sau ɗaya ba ko bata.
Abin da aka ce, wannan har yanzu yana da sabon sabo da wuri. Don haka, yayin da muke da mahimmanci ga waɗanda muke tare da MS, yi ƙoƙari ku yi haƙuri kamar yadda binciken ya bayyana.
> Sources:
> Harlow DE, Gyara JM, Miravalle AA. Gyaran jiyya a ƙananan sclerosis. Neurol na gaba. 2015; 6: 257.
> Nave Ka. Ƙunƙirar da kuma taimakon gogaggun magunguna na dogon lokaci. Nar Rev Neurosci. 2010 Afrilu 11 (4): 275-83.
> Ƙungiyar MS Society ta kasa. (Afrilu 2016). Antihistamine ya nuna alamar tabbatar da ƙwayar sallah a ƙananan matakai na II MS Nazarin.
> Zhornitsky S et al. Gwagwarmaya mai yawa don maganin sclerosis mai yawa: mayar da hankali kan gyara gyaran gyare-gyaren myelin. CNS Neurosci Ther . 2013 Oktoba; 19 (10): 737-44.