Fluoroquinolones sune maganin rigakafi
Idan kuna karatun wannan labarin, an umarce ku da ciprofloxacin (Cipro), levofloxacin (Levaquin) ko wani irin nau'i na fluoroquinolone don maganin kamuwa da cuta na kwayan cuta (tunani na numfashi ko kuma kamuwa da cutar urinary). Gaba ɗaya, waɗannan kwayoyi suna da lafiya kuma suna da tasiri a kan tsararren cututtukan kwayoyin cuta da kwayoyin cutar marasa lafiya na kwayoyin cuta wadanda suke sanya su kyakkyawan zabi don kulawa ta jiki ko tsarin jiki.
A ainihin dukkanin kwayoyin launin fata-ciki har da kwayoyi irin su ciprofloxacin da levofloxacin - sun kasance da haɗin haɗin ƙwallon ƙafa shida da aka haɗe da nau'in hawan gwal. Wadannan kwayoyi sunyi aiki da samuwa 2 kwayoyin enzymes da ke da alhakin ƙwarewa, sutura, da kuma rufe DNA a yayin yadawa: DNA gyrase da topoisomerase IV. Saboda halin yanzu suna da nasaba da nau'o'in enzymes guda biyu, yana da wuya ga kwayoyin cutar su canzawa kuma su guje wa ayyukan wadannan kwayoyi.
Ga jerin kwayoyin da cewa fluoroquinolones suna aiki akan:
- Staphylococci
- Streptococcus pneumoniae (levofloxacin da moxifloxacin sun fi tasiri)
- Staphylococci viridans
- Bacillus anthracis (ciprofloxacin an yarda ya bi da anthrax)
- Chlamydia (levofloxacin da moxifloxacin sun fi tasiri)
- Enterococcus faecalis
- Listeria monocytogenes
- Kwayoyin Nocardia
- Neisseria meningitides da gonorrhoeae
- Haemophilus influenzae
- Jinsin Enterobacteriaceae
- Pseudomonas aeruginosa (ciprofloxacin ya fi tasiri)
- Vibrio jinsuna.
Mafi mahimmanci, masu amfani da kwayoyi suna aiki a kan marobes da kuma anaerobes. Anaerobes, duk da haka, yawanci suna magance wadannan magunguna.
Ga jerin jerin cututtuka na kwayan cuta cewa fluoroquinolones kamar ciprofloxacin da levofloxacin bi da bi:
- Ciwon huhu
- Bronchitis
- Anthrax
- Gastroenteritis na kwayar cuta (mura mai ciwo)
- Hanyoyin da ke cikin mahaifa
- Babban ciwo
- Septicemia
- Pelvic cutar cututtuka
- Hadin gwiwa tare da kashi
- Sinusitis
- Hadin gwiwa tare da kashi
- Abun ciki mai ciki
Bugu da ƙari, ɗaukar hoto mai tsanani, masu amfani da kwayoyi suna wasa da wasu kayan da suka sa su maganin rigakafi. Na farko, an dauki su ta bakin (kuma ba a allura ba). Abu na biyu, suna rarraba da kyau a cikin bangarori daban-daban. Na uku, masu amfani da kwayoyi suna da tsawon rai mai rai wanda ya ba su izinin magance su sau ɗaya ko sau biyu a rana. Hudu, ciprofloxacin da levofloxacin suna da yawa daga kodan da suke sa su da yawa a yakin da ake fama da su.
Ga mafi yawancin, masu tsauraran kwayoyi suna da lafiya sosai. Duk da haka, suna iya haifar da wasu cututtuka masu haɗari ciki har da:
- Castrointestinal disturbances (ciki ciki)
- Allergic halayen (fata rash)
- Ciwon kai
- Riƙe
- Majalisa
- QT ƙarewa (rikicewar lantarki na zuciya da ke gani akan ECG)
- Gyara ragi
- Angiodema (fatar jiki)
- Hotunawa
Bugu da ƙari, abubuwan da ke faruwa a sama, mafi wuya, magunguna na iya haifar da ciwon hanta kuma haɓaka hanta enzymes. Maganar da aka yi a baya sun kasance sananne don haifar da hanta (tunanin gatifloxacin da trovafloxacin) kuma an cire su daga kasuwa.
A halin yanzu, damar da kowane mummunan cutar da ke haifar da hanta yana da mutane 100,000. Saboda lavofloxacin da ciprofloxacin sune maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin cutar. Irin wannan ciwon hanta yana faruwa ne sau ɗaya zuwa hudu bayan gwanin fluoroquinolone.
Kodayake juriya ga masu amfani da kwayar cutar ba su da yawa fiye da tsayayya da wasu maganin maganin rigakafi, har yanzu yana faruwa musamman a tsakanin staphylococci (MRSA), Pseudomonas aeruginosa, da Serratia marcescens. Kuma da zarar ɓangaren kwayoyin cuta sunyi tsayayya da wani fluoroquinolone sannan kuma yana da tsayayya da su duka.
Idan kai ko wanda kake ƙaunatacce an tsara shi da kwayoyin halitta-ko kowane kwayoyin halitta don wannan kwayar halitta - yana da mahimmanci ka kammala aikinka. Ta hanyar barin magani a cikin tsakiyar lokacin-bayan da kake "jin" mafi kyau-ka taimakawa wajen zaɓin, tsira, da kuma yada kwayoyin kwayoyin cuta wanda zai zama babban damuwa na lafiyar jama'a. Ka tuna cewa muna yin yaki da maganin rigakafi kullum, kuma mun rasa fadace-fadace idan rikici ya fito.
Sources:
Deck DH, Winston LG. Sulfonamides, Trimethoprim, & Quinolones. A cikin: Katzung BG, Trevor AJ. eds. Basic & Clinical Pharmacology, 13th . New York, NY: McGraw-Hill; 2015. An samu damar shiga Maris 29, 2015.
Guglielmo B. Anti-Ingantive Chemotherapeutic & Agent antibiotic. A cikin: Papadakis MA, McPhee SJ, Rabow MW. eds. Sanarwar Asibiti na Yanzu da Jiyya 2015 . New York, NY: McGraw-Hill; 2014. Samun damar shiga Maris 29, 2015.
RYAN KJ, RAY C. Agents na Antibacterial, da Resistance. A cikin: RYAN KJ, RAY C. eds. Sherris Medical Biology, Edition na shida . New York, NY: McGraw-Hill; 2014. Samun damar shiga Maris 29, 2015