Verapamil yana da magani mai mahimmanci da ake amfani dasu don magance cututtukan zuciya. Domin yana kawar da jini na zuciya da jikin duka, yana da aikace-aikace na asibiti mai yawa. Bugu da ƙari, yana da amfani da yawa, dole ne a kula da sashin maganin karamar ƙira don kulawa da shi saboda wannan magani yana haifar da hadarin haɗari kuma yana da mummunar tasiri. Alal misali, haɗari na cin nama ɗaya daga cikin yara zai iya zama m.
Kayan aikin
Verapamil shi ne mai caji mai tsaka-tsakin (antagonist) wanda ya rage yawan shigar da katakon murci ta hanyar tashoshi mai launi na L a cikin ƙwayoyin zuciya da kuma ƙwayoyin tsofaffin ƙwayoyin jikin jiki.
Vedraamil tana da ilimin ilimin lissafi:
- Rushewar duka biyu na zuciya (zuciya) da kuma arteries da arterioles
- Rage kwangilar zuciya
- Kuskuren sinus nauyin aiki
- Tsayar da haɓaka kumburi mai amfani da ƙwaƙwalwa
Bugu da ƙari, abubuwan da ke faruwa a sama, ƙananan dangi suna shawo kan ƙwayar ƙarfin zuciya na kwayoyin zuciya, yana ƙarfafa zuciya akan carbohydrates maimakon albarkatun mai masu kyauta. Bugu da ƙari, 'yan gudun hijira sun hana yin amfani da insulin. Wadannan canje-canje biyu masu guba sun zama sananne a lokuta masu tsada idan jiki yana bukatar carbohydrates.
Metabolism
Verapamil yana da kyau ta hanyar amfani da gastrointestinal tract kuma yana rarraba a ko'ina cikin jiki (kashi 90 cikin dari na gina jiki).
A kan haɗin gwanin farko, fasalin da ke cikin hanta ya rushe shi a cikin mai aiki mai aiki. Rawan rabin rai na Verapamil shine kimanin sa'o'i takwas.
Amfani na asibiti
Saboda sakamakonsa a kan zuciya da kuma fashewar jiki (jini), verapamil yana da amfani da dama. Ga wasu hanyoyin da ake amfani da su:
- Angina (barga, m da kuma 'yan jarida)
- Ƙananan tachycardia
- Tarihin Raynaud
- Ciwon prophylaxis na Migraine
- Cigar ciwon ciwon ciwon kai
- Madacciyar hawan jini ko kyama
Vedraamil wata magani ne mai ƙwayar cuta. Kafin likitoci sun yi amfani da ƙananan dabbobi don magance arrhythmias, ana amfani da propranolol da digoxin.
Hanyoyin Cutar da Abun Harkokin Drug
Kodayake rare a karkashin kulawa na kusa da likitan kwalliyar zuciya, yawancin abin da ke damuwa da shi shine damuwa. Bugu da ƙari, da nasa mummunar tasiri, iyalan dangi na iya yin hulɗa tare da wasu magunguna masu yawa.
Mafi yawan mummunan sakamako na verapamil shine ƙyama. A wasu mutane, ƙananan yara na iya haifar da dizziness, hasken haske, da kuma tsinkaye. A lokuta na yawan abin sama da ya kamata, ƙwaƙwalwar ƙwaƙwalwa ta katse tare da muryar zuciya kuma zai iya haifar da asarar rayuwa.
Ga wasu magungunan miyagun ƙwayoyi da ke nuna cewa:
- Vedraamil yana amfani da beta-blockers, nitrates da diuretics cutar karfin jini na iya haifar da kawanin jini ya fāɗi da ƙananan low (hypotension).
- Verapamil na iya kara yawan tasirin statins, wanda ake amfani dashi don magance babban cholesterol, kuma statins zai iya haifar da rhabdomyolysis ko raunin jiki wanda ya keta tare da kodan.
- Verapamil yana cike da kwayar cutar cytochrome P450 da amfani da magungunan likita kamar sindarone (wani antiarrhythmic) ya shafe tare da manyan abubuwa P450 da ke haifar da maye gurbi. Bugu da ƙari, ruwan 'ya'yan ganyayyaki yana shafar tsarin P450 kuma zai iya ƙara yawan karuwar jini na verapamil.
Don Allah a tuna cewa lokacin da aka yi amfani dashi kamar yadda aka shawarta kuma a cikin wani tsari mai kyau, iyalan auren zai iya zama babban amfani ga waɗanda suke buƙata. Bayanan da ke cikin wannan labarin ba nufin jin tsoron ku daga amfani da verapamil lokacin da aka shawarce ku ba. Duk da haka, dole ne ku kula da shawarar likitanku yayin amfani da wannan, ko wani, magani.
Idan kai ko ƙaunatacciyar yana ɗaukar auren mata, yana da mahimmanci cewa mai binciken likitancinka ya kula da ku. Yi alƙawari don dubawa na yau da kullum tare da likitan zuciyar ka kuma tabbatar da sanar da likitanka game da kowane canje-canje a tsarin shayarwa ciki har da kowane amfani da magunguna.
Bugu da ƙari kuma, idan kuna jin duk wani mummunar tasiri wanda zai iya kasancewa a tsakanin dangin kuɗi kamar ƙuntatawa ko rashin hasara na wucin gadi, ku nemi taimakon gaggawa.
Sources:
Lynch, T da Price, A. "Hanyoyin Cytochrome P450 Metabolism a kan Mutuwar Drug, Abokin hulɗa, da Harkokin Cutar" likitancin iyali na Amirka. 2007.
Maganin Ciwon Magunguna na Mosby ga Ma'aikatan Lafiya, Darasi na Biyu . Elsevier. 2010.
Tomaszewski CA, Benowitz NL. Babi na 40. Maƙallan Maƙallan Maciji. A: Olson KR. eds. Cigaba da Drug Overdose, 6th . New York, NY: McGraw-Hill; 2012.