T4T3 don Asarar Matsa? Binciken Sakamakon Kasuwancin Combo
Kwararrun sananne tsakanin marasa lafiya, da wasu likitoci, cewa yawancin marasa lafiya da hypothyroidism zasu ci gaba da samun gunaguni da bayyanar cututtuka, duk da lura da levothyroxine wanda ke kula da matakan da ake kira "thyroid" stimulating hormone (TSH).
Ɗaya daga cikin binciken ya gano cewa, idan aka kwatanta da sarrafawa, fiye da kashi 13% ba su yarda da yanayin lafiyarsu ba, suna nuna rashin jin dadi da maganin su.
Maganganun farko sun kasance da gajiya, wadataccen kwarewa , ƙwaƙwalwar jiki, da ciwo.
A cewar Dokta Bente Appelhof, MD, daga Jami'ar Amsterdam a Netherlands da abokan aikinsa: "Tambaya ta kasance game da darajar magani tare da LT4 da LT3, idan aka kwatanta da LT4 kadai, a cikin magungunan hypothyroidism na farko. ra'ayi cewa yawancin marasa lafiya da hypothyroidism ya kasance tare da gunaguni na lafiyar jiki, duk da maye gurbin farfado da levothyroxine da kuma ƙaddamar da kwayar cutar TSH.
Sauran binciken binciken dabba sun nuna cewa maye gurbin farfadowa tare da levothyroxine (LT4) kadai baya tabbatar da rashin lafiya - al'ada maganin thyroid - a cikin dukkan kyallen takarda. Maimakon haka, za a iya samun ƙwayar cuta kawai ta hanyar haɗin gwiwa na LT4 da na honeythyronine (LT3). Ɗaukar karatu da yawa sun mayar da hankali akan wannan batu, suna duban ko farjin LT4 bazai isa ya sake mayar da ita a cikin jikin mutum ba.
Duk da yake marasa lafiya sun bada rahoto game da yadda ake son nazarin haɗaka, masu bincike ba su iya rarraba wasu abubuwan da suka inganta ba.
Yanzu, masu bincike sun gano akalla ɗaya daga cikin abubuwan da ke nuna alaka da hadewa - asarar nauyi.
Binciken da aka buga a Journal of Clinical Endocrinology da Metabolism ya ruwaito a kan wani binciken da ya gano cewa marasa lafiya sun fi son maganin maganin maganin jinya wanda ya haɗa da hade da levothyroxine (T4) da T3, maimakon jinin levothyroxine (T4 kawai), kuma an hade magunin hade tare da asarar nauyi.
Wannan babban jarrabawar jarrabawar ta tabbatar da binciken daga binciken Bunevicius, wanda aka buga a New England Journal of Medicine, wanda ya sami sakamako mai amfani na hade T4 / T3 maganin hypothyroidism.
Kwanan nan makafi, bazuwar, gwajin gwagwarmayar gwagwarmaya ya dubi marasa lafiya 141 tare da jigilar hypothyroidism na autoimmune, waɗanda suka rabu da kungiyoyi waɗanda aka bi da T4 / T3 a cikin rabo daga 5: 1, 10: 1, da kuma ƙungiya mai ci gaba tare da maganin T4-kawai. Bayan makonni 15, binciken ya nuna fifiko a kan sassan marasa lafiya don maganin haɗuwa, kuma musamman magunguna 5: 1 da ke nuna matakan T3, tare da maganin T4 kawai.
Wasu takamaiman abubuwan da suke sha'awa:
- Raguwar nauyin jiki - amma ba rage a magani TSH - an hade shi tare da karuwa da yawa tare da nazarin binciken.
- A cikin ƙungiyoyi masu haɗaka guda biyu, akwai karuwar nauyin nauyi, mafi mahimmanci a cikin rukunin rabo na 5: 1, wanda yana da karuwar 1.7 kg, ko 3.75 fam. Ƙungiyar 10: 1 tana da asarar nauyi na 1 laban. Ƙungiyar T4-kawai ba ta canza canji ba.
- Daga marasa lafiya wadanda suka fi son farfesa, 44% na da magani TSH kasa da 0.11.
- Canjin canje-canje a cikin yanayi, gajiya, jin daɗin rayuwa, da kuma ayyuka na neurocognitive ba za a iya gano su a bayyana bayanin likitanci game da hadewa.
Ɗaya daga cikin mahimman bayanai a cikin binciken shine cewa wasu marasa lafiya da ke haɗuwa da maganin suna samun maganin ƙuntatawa, wanda ake la'akari da rikici. Suna da matakan TSH da ke ƙasa da al'ada, kuma saboda haka ana daukar su hyperthyroid.
"Marasa lafiya sun fi dacewa da haɗin gwiwa na LT4 / LT3 zuwa ka'idar LT4, amma canje-canje a yanayi, gajiya, jin daɗin rayuwa, da kuma ayyukan da ba a iya amfani da shi ba zai iya bayyana dalilin da ya sa dalilin farko ya kasance na goyon bayan littattafan LT4 / LT3," marubuta sun rubuta. "Rage yawan nauyin jikin ya danganta da gamsuwa da magani na nazarin."
Yayin da marubuta masu binciken ba su iya samun dalilin da zai iya ba da shawara ga haɗuwa da juna ba, sun yanke shawarar: "Duk da haka, sakamakon wannan binciken ba ya hana yiwuwar wani rukuni na marasa lafiya zai iya amfana daga farfadowar LT4 / LT3."
Sources:
Appelhof BC, et. al. "Hadin haɗin gwiwar da levothyroxine da cythothyronine a cikin kashi biyu, idan aka kwatanta da levothyroxine monotherapy a cikin hypothyroidism na farko: shaidu guda biyu, bazuwar, da gwaji na gwaji."
Saravanan et. al. Sashin lafiya na marasa lafiya a cikin marasa lafiya a kan 'isasshen' ingancin l-thyroxine: Clin Endocrinol (Oxf) 57: 577-585)