Juxtapid (lomitapide) magani ne da ake amfani dashi mafi yawan ƙwayar cholesterol, LDL, da kuma apolipoprotein B - tare da abinci da sauran jiyya - a cikin mutane tare da homozygous familial hypercholesterolemia , yanayin da ke da nasaba , wanda ya haifar da matakan LDL cholesterol da ciwon zuciya cuta a farkon rayuwa. An amince da Juxtapid don amfani da shi a Amurka ta hanyar Abinci da Drug Administration a watan Disamba 2012.
Juxtapid ne kawai aka bincike sosai a cikin mutanen da aka gano tare da homozygous iyali hypercholesterolemia - kuma ba a cikin mutane da wasu yanayi haifar da high cholesterol matakan. A cikin binciken daya, an yi amfani da Juxtapid 5 zuwa 60 m kowace rana ga mutanen da ke shan wasu ƙwayoyin cutar cholesterol-ragewa don matakan da suka dace na LDL cholesterol. Wannan binciken ya nuna cewa ƙara Juxtapid zuwa sauran hanyoyin kwantar da hankali ya ƙaddamar da matakin LDL ta hanyar zuwa kashi 50%. Tsarin Triglyceride, matakan apolipoprotein B, VLDL da kuma yawan ƙwayoyin cholesterol kuma an rage su sosai.
Wani binciken kuma yayi nazarin tasiri da aminci a cikin mutanen da ke da irin wannan yanayin likita dauke da Juxtapid kadai don rage yawan ƙwayar cholesterol. A ƙarshen wannan binciken, a kashi na 1 MG / kg / rana, matakan LDL da apolipoprotein B matakan da aka saukar da kimanin kashi 50%.
Kodayake wadannan binciken sun taimaka wajen rage yawan ƙwayar cholesterol a cikin yawan mutanen da suka kamu da cutar, sun kuma bayyana cewa Juxtapid na iya haifar da sakamako mai tsanani - ciki har da cututtuka na gastrointestinal da cutar hanta.
Bugu da ƙari, tun lokacin da waɗannan nazarin sun ci gaba har zuwa makonni 70, ana gudanar da wasu nazarin a halin yanzu don tabbatar da aminci da tasiri na Juxtapid.
Ta yaya Yayi aiki?
Juxtapid yana rage LDL cholesterol ta hanyar hana kwayar cutar canza jiki na kwayoyin triglyceride (MTTP), kwayar dake cikin jikin da ke hana VLDL da kuma chylomicrons daga hanta.
Saboda VLDL ya koma cikin LDL, hakan zai rage matakan LDL cikin jini.
Yaya Ya Kamata Na Sami Wannan Magunguna?
Juxtapid ya kamata a dauki baki, tare da gilashin ruwa, a cikin komai a ciki. An nuna cewa ana daukar magani a akalla sa'o'i biyu bayan abincin dare. Mai bada sabis na kiwon lafiya zai gudanar da gwaje-gwaje na jini - ciki har da nazarin hanta enzymes da ƙananan cholesterol - kafin a rubuta Juxtapid zuwa gare ku.
Hanyoyin da za a iya yiwuwa
Abubuwan haɗari da hanta da hanta da haɗari a cikin hanta sun danganci haɗuwa da shan Juxtapid. Saboda haka, likitan ku na buƙatar ɗaukar gwajin jini na lokaci don ƙayyade matakan enzyme na hanta, wanda ya haɗa da alanine aminotransferases, aspartate aminotransferases, da kuma phosphatase alkaline, ban da kulawa da matakan cholesterol. Saboda wadannan cututtuka, Juxtapid yana dauke da "gargadi na bango" don rashin haɓaka, wanda shine babban shiri da Cibiyar Abincin da Drug ta bayar ta hanyar cewa an tabbatar da wannan sakamako a cikin nazarin lafiyar miyagun kwayoyi. Saboda mummunar cutarwa Juxtapid yana da hanta, likitanku zai sa ku shiga cikin shirin ƙuntatawa, wanda aka kira shi shirin Juxtapid REMS.
A karkashin wannan shirin, ƙwararrun likitoci da magungunan ƙwayoyi waɗanda ke da ƙwarewa don fahimtar maganin da kuma hadarinsa zasu iya tsarawa da rarraba Juxtapid.
Abubuwa masu lalacewa na gastrointestinal, irin su nausea, vomiting, ƙwannafi, cututtuka, ƙarfin zuciya da ciwo na ciki, sun kasance mafi yawan abin da ya faru a cikin mutanen da ke shan Juxtapid. Wasu mutane sun bayar da rahoto suna fuskantar asarar nauyi, zafi ciwo, da gajiya yayin shan magani.
Wanene bazai dauka ba ?
A halin yanzu, an kirkiro Juxtapid a cikin mutane da aka gano tare da homozygous iyali hypercholesterolemia saboda mummunar haɗari ga cututtukan zuciya na zuciya.
Saboda haka, ba a sani ba idan Juxtapid yana da tasiri a cikin mutane tare da wasu yanayin kiwon lafiya wanda ke haifar da matakan cholesterol. Sauran mutanen da zasu shawarci likita kafin su dauki Juxtapid sun hada da:
- Mutum tare da cututtukan hanta - Juxtapid zai iya ƙara haɓaka hanta enzymes kamar transaminases kuma ƙara hanta mai.
- Mutane da cutar cututtuka - Juxtapid matakan zai iya ƙara cikin jini.
- Mata masu juna biyu - Juxtapid ya nuna cewa yana da cutarwa ga tayin a nazarin dabba. Mata masu iya haifuwa zasu buƙaci gwajin ciki na ciki kafin fara Juxtapid kuma zasu buƙatar amfani da wasu nau'i na kulawar haihuwar haihuwa yayin shan shan magani.
- Mata masu jinya - Juxtapid ba a yi nazari sosai ba. Saboda yiwuwar ci gaba da ciwon tumo a cikin ƙananan ƙwayoyi, an bada shawarar cewa an dakatar da jinya - ko kuma miyagun ƙwayoyi.
Drug Interactions
Akwai wasu magunguna da zasu iya hulɗa tare da Juxtapid, wanda zai haifar da tasiri akan Juxtapid ko sauran magunguna a jiki. Wadannan su ne jerin taƙaitaccen magunguna da zasu iya hulɗa tare da Juxtapid haka idan ka dauki daya ko fiye daga cikin wadannan magunguna, ya kamata ka tuntuɓi likitanka.
- Abincin mai gina jiki mai gina jiki da kayan abinci, irin su Vitamin A, D, E, da K, da omega-3 mai fatty acid , bazai iya tunawa ba yayin shan Juxtapid.
- Juxtapid zai iya ƙara yawan jini na wasu nau'in jini , irin su warfarin, cikin jini. Wannan zai iya haifar da zubar da jini ko ƙeta mafi sauƙi.
- Idan kuna shan atorvastatin ko simvastatin, Juxtapid zai iya ƙara yawan jini na wadannan magunguna. Kwararka zai iya canza yawancin wadannan magunguna yayin shan Juxtapid.
Saboda hanyar Juxtapid da ke cikin jiki, zai iya ƙara yawan jini na wasu magunguna da kake dauka - saboda haka sa magunguna ya fi mai guba. Wadannan sun haɗa da wasu kwayoyi marasa amfani, maganin maganin rigakafi, kwayoyin maganin rigakafi, magungunan jini, magungunan da ake amfani da su don kula da ƙwannafi, da samfurori na halitta (irin su goldenseal, kazamar). Sabili da haka, ya kamata ka ci gaba da sanar da duk ma'aikatan lafiyarka game da duk wani magunguna da kake ɗauka domin su iya magance kyakkyawar hulɗa tare da Juxtapid. Kwararka na iya yanke shawara don canza juyin Juxtapid ko wasu magunguna idan an gano hulɗar.
Layin Ƙasa
Juxtapid shi ne karo na farko na cholesterol-ragewan magani da aka yarda da cewa ya hana MTTP. Kodayake nazarin ya nuna cewa Juxtapid ya kara ƙarin ikon LDL-ragewa a cikin mutanen da ke da homozygous hypercholesterolemia, akwai wasu matsalolin kare lafiyar da ke hade da Juxtapid kuma an yi amfani da amfani ga wannan yanayin cututtukan musamman saboda wadannan hadarin. Likitanka zai tantance amfanin shan Juxtapid, tare da hadari na fuskantar maganganu masu illa tare da miyagun ƙwayoyi. Saboda abubuwan da ake dadewa na shan Juxtapid ba su sani ba - ciki har da ikon iya hana cutar cututtukan zuciya - akwai nazarin da ke gudana a halin yanzu don nazarin wannan.
Sources:
Cuchel M, Meagher EA, Theron HD, et al. Ƙarfafawa da kuma lafiyar wani ƙwayar cuta mai gina jiki na triglyceride na microsomal a cikin marasa lafiya tare da homozygous familial hypercholesterolemia: guda-hannu, bude-lakabi, lokaci 3 binciken. Lancet 2013; 381 (9860): 40-6.
Cuchel M, Bloedon LT, Szapary PO, et al. Tsarin magungunan kwayoyin triglyceride na microsomal canza jiki cikin iyali hypercholesterolemia. N Eng J Med 2007; 356: 148-156.
Juxtapid ® (bugawa) Kunshin saiti. Aegerion Pharmaceuticals. Maris 2016.