Abubuwa na P Has Proinflammatory Effects
Ta yaya aka gano Mafarki P?
An fara gano abu P a 1931, amma muhimmancinsa a cikin jikinsa ya dauki shekarun da suka gabata. A cikin shekarun 1950, an ƙaddara cewa abu P shi ne mai neurotransmitter. Kwayoyin jijiya ta sadarwa ta hanyar neurotransmitters. An samo abu P a matsayin mai ɗaukar zafi na ƙarfin dorsal. Ƙungiyar ƙarewa ta ƙunshi ƙananan ƙwararrun kwayoyin halitta kuma ana samuwa a kowane ɓangaren ƙwayoyi.
A cikin shekarun 1970s, an bayyana abubuwa masu magunguna na abu P. An gano abu mai mahimmancin P a matsayin mai gina jiki wanda ya hada da jerin amino acid.
Matsayi na abu P cikin Jiki
An gudanar da dabbobi mai yawa da kuma nazarin in vitro don a iya fahimtar muhimmancin abu P cikin jiki. Masu bincike sun gano cewa abu P ya wahalar da ciwo ta hanyar da aka sani dashi. Wani ƙwararren kwayar halitta ne mai ƙwayar jiki ko kwayar tausayi wanda ya haifar da yiwuwar haifar da ciwo ta hanyar nuna alamar kashin baya da kwakwalwa. Rashin ƙaddamarwa yana haifar da hangen nesa. Haka kuma an gano cewa abu P yana da tasiri mai zurfi.
Magani P kuma mai karɓar mai karɓa, neurokinin-1 (NK-1) mai karɓa, sun kasance a cikin ƙananan kwakwalwa da ke kewaye da neuroaxis (watsi da ke gudana ta cikin kwakwalwa da kashin baya). Wadannan naurori suna taka rawar gani a cikin zafi, damuwa, da damuwa. Maganin P yana kuma kasancewa a cikin tsarin lalataccen tsarin tsarin kulawa na tsakiya, ciki har da hypothalamus da amygdala.
Wadannan wurare suna da nasaba da halayyar motsa jiki.
Baya ga fahimtar jin zafi, damuwa, da damuwa, abu mai mahimmancin P ya samo a taka muhimmiyar rawa a cikin wasu maganganun ilimin lissafi:
- vomiting
- yanayin tsaron
- canji a cikin sautin zuciya na zuciya
- motsa jiki na kariya
- sasantawa muscle m
- vasodilation
Abu P da Arthritis
Masu bincike sunyi nazarin yadda ake amfani da abu P a cikin cututtukan zuciya da cututtuka. Domin abu na P don taka rawa wajen maganin arthritis, tsarin kulawa dole ne ya shiga cikin pathophysiology na arthritis. Dole ne ya zama dabarun ƙwaƙwalwar asali a cikin haɗin gwiwa . Wasu bincike sun nuna cewa shine lamarin:
- An samo Maganin P a wasu wurare masu mahimmanci.
- Magani P yana samuwa a cikin mafi yawan haɗuwa a cikin ruwa na synovial na marasa lafiya na arthritis mai rheumatoid .
- Yawan masu karɓar abubuwa P ne daban-daban a cikin nau'in rheumatoid.
Levine et al. sunyi tunanin cewa hanyoyin da ke tattare da hanyoyi na iya samar da bayani game da wasu siffofin da ke tattare da maganin cututtuka na rheumatoid: wasu takamaiman takalma zasu iya haifar da arthritis; takamaiman takalmin ci gaba da inganta ƙwayar cututtuka; da kuma alamun dakunan da ke fama da cututtuka na rheumatoid yana da dangantaka da daidaituwa. Lotz et al. gano wani tasiri mai mahimmanci ga abu P a arthritis. Lotz da ƙungiyarsa sun nuna cewa abu P na iya ƙarfafa synoviocytes (sassan jiki na synovial) a cikin arthritis na rheumatoid. Magani P ta ƙara ƙaddamar da prostaglandin da collagenase daga synoviocytes.
Mahimmanci abu P
Shin ya binciko muhimmancin abu P ya ba da wani sabon maganin maganin arthritis na rheumatoid?
Ba daidai ba. Amma, masu bincike sunyi iƙirarin yiwuwar mai karɓar mai karɓa na NK1 (mai shinge) don a bunkasa a matsayin magani ga cututtuka na rheumatoid. Kafin nan:
- Glucocorticoids zai iya rage kumburi da ya samo asali a cikin nervous nama ta hanyar rage yawan magana na NK-1, yayin da kara samar da wani enzyme wanda zai haifar da lalacewar abu P.
- Hanyoyin maganin magunguna na iya rage abu P daga ƙwayar ƙwayar jiki don taimakawa zafi. A cewar masanin ilimin rheumatologist, Scott J. Zashin, MD, capsaicin zai iya daukar makonni 1 zuwa 4 don aiki. Don kula da amfanin jin daɗin ciwo, dole ne a sake amfani da capsaicin bisa ga sharuddan.
Matsayi na Magani P a Cikin Ƙananan Ra'ayin Bayan Tuntun
Bayani game da muhimmancin abu P a cikin mummunan cututtuka bayan shan tiyata a marasa lafiya tare da yanayin ciwon kumburi na yau da kullum ba shi da yawa, kamar yadda bayani game da haɗin tsakanin matakan P da canji da zafi. Bisa ga shirin PLoS One (2016), masu bincike sunyi nazarin daidaitawa tsakanin matakan P da kuma ciwo mai tsanani a cikin marasa lafiya da cututtuka na rheumatoid wanda ke yin aikin tiyata kothopedic. Sun gano cewa haɗin tsakanin mummunar zafi da tsanani da kwayoyin halitta P ya faru ne a cikin marasa lafiya da cututtuka na rheumatoid, amma ba a iya ganowa cikin ruwa mai tsabta ba.
> Sources:
> Garret NE et al. Matsayi na abu P a cikin ƙwayoyin cuta na inflammatory . Annals of the Rheumatic Diseases 1992; 51: 1014-1018.
> Keeble da Brain. Matsayi ga Abinci P a Arthritis? Neuroscience Letters. Volume 361. Issoshi 1-3, 6 Mayu 2004. Shafuka 176-179
> Levine JD, Collier DH, Basbaum AI, Moskowitz MA, Helms CA. Tsammani: tsarin mai juyayi zai iya taimakawa wajen maganin cututtukan maganin arthritis. Jaridar Rheumatology. 1985, 12 (3): 406-411.
> Lisowska, B. et al. Magani P da Mutu mai tsanani a cikin marasa lafiya Kewaya da tiyata. PLoS Daya. 2016 Janairu, 11 (1): e0146400. Doi: 10.1371 / journal.pone.0146400.
> Lotz M, Carson DA, Vaughan JH. Magani P kunna aikin synoviocytes rheumatoid: hanyar da ke cikin jiki a cikin maganin ƙwayar maganin maganin ƙwayar cutar. Kimiyya. 1987 Feb 20; 235 (4791): 893-5.
> O'Connor T et al. Matsayi na abu P a cikin cutar cututtuka. Journal of Cell Physiology. 2004 Nov; 201 (2) 167-80.