Wani magani da ake kira mirogabalin yana ba da begen samun taimako na alama tare da ƙananan illa da labarun fibromyalgia (FMS) na yanzu . Ya yi da wuri don sanin tabbas, ko da yake.
Mirogabalin wata magani ne na gwaji wanda shine memba na uku na '' iyali 'na magunguna wanda ya saba da al'umma ta FMS. Mahalarta ita ce Neurontin (gabapentin) da Lyrica (pregabalin) , wanda ake kira "dan Neurontin."
Neurontin da Lyrica sune magungunan maganin magungunan rigakafin da aka samo tasiri ga ciwo na neuropathy na ciwon sukari . Lyrica shi ne FDA-an yarda da FMS da Neurontin wanda ake kira takaddama akan shi. Ana kuma amfani da su don sauran nau'o'in ciwo, ciki har da ciwon daji bayan post- mint da neuralgia .
Mirogabalin, duk da haka, an ƙaddamar da shi musamman tare da neuropathic da FMS baƙin ciki.
Yadda Mirogabalin ke aiki
A cewar kamfanin dillancin labaran kasar Japan Daiichi Sankyo, mirogabalin yana ɗaure ga tashar calcium a kwakwalwa, kamar Lyrica da Neurontin. Duk da haka, mirogabalin a gwargwadon rahoto yana ɗaure fiye da Lyrica, wanda zai iya haifar da rashin rinjaye.
A halin yanzu, mummunan illa mai lalacewa zai iya zama babban matsala tare da Lyrica, Neurontin, da sauran kwayoyin FMS. A gaskiya, mutane da yawa sun daina shan waɗannan magungunan saboda su. Idan tsammanin tsammanin saiti da kuma mirogabalin yana ba da taimako na jin zafi tare da ƙananan halayen halayen, zai zama babban abu ga mutane da wannan yanayin.
Mirogabalin kuma an yi imani da cewa ya fi tsayi fiye da Lyrica, ma'ana yana iya buƙata a ɗauka sau da yawa. Nazarin watan Janairun 2016 ya nuna cewa sau biyu a kowace rana zai iya zama mafi kyau don rage yawan tasiri.
Domin Fibromyalgia da Neuropathy
Daiichi Sankyo yana gudanar da bincike akan mutum dubu kan mirogabalin na FMS.
Wannan bincike ne na musamman (kuma mai tsada) don farkon wannan tsari, wanda ke nuna cewa kamfanin yana da tsammanin sakamakon.
Drug nazarin sau da yawa kwatanta magani zuwa placebo, amma wannan shi ne raft mirogabalin kai-da-kai a kan Lyrica.
Wani binciken da aka buga a shekara ta 2014 ya nuna cewa mirogabalin ya nuna alkawarinsa a matsayin magani ga neuropathy na jiki mai ciwon sukari.
Wani nazarin da aka yi a kwanan nan wanda aka kiyasta cewa mirogabalin na iya zama kamar sau 17 sau da yawa fiye da Lyrica; duk da haka, wasu masu bincike sun soki nazarin binciken.
Yankewa
Ba a riga an kafa magungunan gyaran gyaran ba. Nazarin da ya samo gwargwadon iko na 17 wanda aka ambata a sama an kiyasta cewa sashi zai iya zama 17.5 MG ko žananan, idan aka kwatanta da 150 mg na Lyrica.
Nazarin Neuropathy suna amfani da 15 mg, 20 MG, ko 30 mg dosin.
Shaidun farko sun nuna cewa ƙananan dosages na iya zama wajibi ga waɗanda ke fama da matsaloli na koda.
Hanyoyi na gefe da Gargadi
Ana iya yin amfani da kwayoyi tare da kowace magani kuma yawancin su ba a sani ba sai bayan sun kasance a kasuwa don 'yan shekaru.
Ya zuwa yanzu, bincike ya nuna cewa mirogabalin zai iya danganta da:
- dizziness
- barci
- barci na tsawon lokaci
- ciwon kai
Yaya Zamu Yi Magana?
Nazarin magungunan aiki ne mai sauƙi. Da farko babban gwaji da aka fara a shekara ta 2015, kuma ya hada da yawancin mahalarta, ba zamu iya tsammanin ganin sakamakon da zai yiwu a 'yan shekarun nan ba.
Idan mirogabalin ya ci gaba da nuna alkawarinsa kuma Sabuwar Maganin Drug Application ya wuce gaban FDA, zai iya ɗaukar wasu shekaru biyu don yarda da shi.
Saboda haka, yayin da yake ƙarfafawa don sanin cewa maganin da ke ba da taimako na jin zafi tare da ƙananan sakamako masu illa zai iya kasancewa a nan gaba, muna bukatar mu ci gaba da neman magunguna na yanzu wanda zai taimaka mana wajen sarrafa alamun bayyanar.
> Sources:
> Jarabawa na Clinical Clinics. "Mene ne Mahimmanci game da Mirogabalin? Magana mai ban sha'awa akan sabon binciken mu na Fibromyalgia." Duk haƙƙoƙin haƙƙin mallaka.
> Calandre EP, Rico-Villademoros F, Slim M. Ƙwararriyar kwarewar neurotherapeutics. 2016 Jul 7: 1-15. [Epub gaban bugawa] Alpha2delta ligands, gabapentin, PGB da MGB: nazari na likitancin likita da kuma maganin warkewa.
> Daiichi Sankyo Company, Limited. "Daiichi Sankyo ya sanar da marasa lafiya na farko a cikin manyan ƙananan cibiyoyi na uku na MIrogabalin." Duk haƙƙoƙin haƙƙin mallaka.
> Hutmacher MM, et al. Journal of Clinical Pharmalogy. 2016 Jan; 56 (1): 67-77. Sakamakon kwaikwayon da ya dace da yawancin ciwon daji na yau da kullum, da damuwa da rashin jin daɗi, ga mirogabalin (DS-5565) a cikin marasa lafiya da ciwon sukari na ciwon neuropathic.
> Sabbin Drug Approvals. "Mirogabalin." Duk haƙƙoƙin haƙƙin mallaka.
> Vinik A, et al. Ciwon sukari. 2014 Dec, 37 (12): 3253-61. Aminci da aminci na mirogabalin (DS-5565) don maganin ciwon sukari na ciwon neuropathic ciwon sukari: wani baƙi, mai makafi guda biyu, placebo- kuma mai sarrafawa-sarrafawa, jigidar gwaji-na-concept lokaci 2 binciken.
> Yin OQ, et al. Journal of Clinical Pharmalogy. 2016 Feb 56 (2): 203-12. Yawancin samfurin pharmacokinetic yawancin jama'a da kuma kwaikwayo don tantance sakamakon rashin lafiya a kan pharmacokinetics na mirogabalin.