Wace rawa za a iya takaita masu zanga-zangar PARP a maganin ciwon nono na nono? Yawancin magungunan da ake kira PARP sun hana nazarin kwanan nan don maganin ciwon nono. Mene ne wannan magungunan magunguna suke yi, kuma menene zai zama rawar da zasu taka wajen gudanar da mutane da ciwon nono?
Game da PARP da DNA Repair
PARP yana da cikakkiyar maganin poly (ADP-ribose) polymerase.
PARP mai gina jiki ne wanda ke da matakai masu yawa a cikin hanyoyin tafiyar da salula, mafi mahimmanci a gyara DNA da kuma tsara kwayar cutar cell (apoptosis). Kwayoyin lafiya zasu iya amfani da PARP su gyara kansu kuma suyi rayuwa ta al'ada. Amma ƙwayoyin cututtuka na iya amfani da PARP don gyara lalacewar DNA, saboda haka ya kara girman ci gaban su. Wadannan cututtuka zasu iya zama masu maganin magani. Akwai wadansu sunadarai PARP daban-daban, kuma kowannensu yana da rawar da zasu taka a cikin ayyuka a cikin sel.
Masu zanga-zangar PARP da kuma Ciwon Cutar Cancer
Mai maganin PARP ne miyagun ƙwayoyi wanda ke kariya daga sunadarai na PARP daga yin aikinsu a gyara sassan kwayar cutar ciwon da ke cikin lalacewa. Chemotherapy da radiation aiki ta hanyar karya DNA na sel don kada su haifa. Wasu nau'o'in ciwon daji suna amfani da enzymes PARP don gyara lalacewar DNA da kuma farfadowa daga maganin jiyya. Ana yin gwajin gwaje-gwaje masu yawa don ganin idan masu hana masu ciwon PARP, tare da sauran maganin ciwon daji, zasu iya toshe protein daga PARP daga lalacewar ciwon daji.
Hanyoyi akan Ciwon Kankara
Idan an saka magungunan PARP zuwa maganin cututtuka na jijiyyar cutar ciwon nono, masu bincike sunyi fatan ciwon daji da suka yi tsayayya da maganin anticancer zai zama m zuwa lalacewa ta DNA. A wasu lokuta, mai yin amfani da PARP zai iya amfani da shi kadai , maimakon a haɗa tare da chemo da radiation.
Har ma mafi kyawun labari shine masu hanawa na PARP ba su da alama su shafi al'ada, wadanda ba su da kwayoyin halitta. Wannan yana nufin rashin illa ga marasa lafiya da kuma dawowa daga jiyya.
Fata ga Magungunan Ciwon Magunguna
Ma'aikata na PARP na iya taimakawa marasa lafiya da marasa lafiya. Mutanen da suke da BRCA1 da BRCA2 maye gurbin kwayoyin halitta suna da mummunar haɗarin bunkasa ciwon nono. Kwayoyin BRCA masu lafiya suna samar da sunadaran da za su iya kawar da ciwon sukari ( ana kiransu kwayoyin cututtuka na tumo ), amma kwayoyin BRCA masu mutunci ba su da ikon yin wadannan sunadaran da suke yaki da kwayoyin cutar kanjamau. Masu hamayya na PARP na iya amfani da rashin karfi a cikin kwayoyin cutar ciwon daji tare da BRCA. Wata hanya da za a iya amfani da shi ga masu hana masu kwakwalwa na PARP na iya zama rigakafin cutar ciwon daji . Mai yiwuwa masu hanawa na PARP za su zama magungunan rigakafi ga mata masu haɗari da kuma za su iya yin amfani da kwayoyin halittu.
Karfafa labarai don ciwon magungunan nono
Ƙananan gwaji na gwaji na PARP sun sami wasu amfanuwa na asibiti daga ƙara wani mai hana PARP zuwa wasu jiyya don maganin ciwon nono na uku . A cikin wadannan nazarin, masu hambarar da PARP sunyi haƙuri. A wannan lokaci kadai hanyar da aka yarda da ita don ciwon ƙwayar nono na ciki shine ingancizumab, amma wannan miyagun ƙwayoyi ba ta da amfani da yawa ga mutanen da ke fama da ciwon nono.
Sauran Ayyuka Ga Masu Cibiyar PARP
Drugs ci gaba tare da masu zanga-zangar PARP suna gwada da dama irin ciwon daji: nono da ovarian, uterine, kwakwalwa, da kuma pancreatic. A shekara ta 2015, an yarda da wani mai gabatarwa na PARP don maganin cutar kanji.
Muhimmancin Sanin Masu Haramtacciyar PARP
Bugu da ƙari, masu hana masu ci gaba na PARP zuwa arsenal na makamai da ke fama da cutar kanjamau suna dubi sosai. Masu haɓaka na PARP sun inganta tasiri na chemotherapy akan magungunan haɗari da ƙwayar cutar nono guda uku, mai yiwuwa ba tare da ƙara yawan tasiri masu illa ba. Wadannan kwayoyi suna bayyana inganta rayuwar rayuwa da kuma cigaba da rayuwa ga marasa lafiya.
Yin gwagwarmayar ciwon nono a matakin DNA tana kama da kalaman na gaba.
> Sources:
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