Sautun Farko Har yanzu Batirin, amma Jiren Maraice Zai zama Sauran
Idan kun kasance a kan maye gurbin maganin hormone, jagororin sun ba da shawara cewa kayi amfani da kwayar karoid a farkon safiya tare da ruwa, a cikin komai a ciki, kuma jira a kalla awa daya kafin cin abinci ko sha kofi.
Bugu da ƙari, ya kamata ku jira har akalla sa'o'i uku zuwa hudu kafin shan wasu magunguna da suke tsoma baki tare da ruwanta, kamar allunan iron ko allurar carbonate.
Duk da haka, binciken bincike guda biyu-binciken daya da aka buga a cikin Journal of Clinical Endocrinology da Metabolism da kuma ƙaddamar da gwagwarmayar da aka yi a baya a cikin Tarihin Magunguna na Intanet wanda ke daukar nauyin wannan levothyroxine (alal misali, Synthroid ko Levoxyl) a lokacin kwanta barci, idan aka kwatanta da abu na farko da safe, na iya zama mafi alhẽri.
Bincike na Gudanar da Shawarar dare zai iya zama mafi kyau
Binciken da aka ruwaito a cikin Journal of Clinical Endocrinology da Metabolism ya dubi tasiri akan gwajin jini ta hormone ta hanyar canza lokacin levothyroxine aka karɓa daga safiya zuwa kwanta barci. Binciken ya kuma kimanta tasiri na wannan canjin lokaci a kan tsarin circadian na thyroid-stimulating hormone (TSH).
Binciken, yayin da yaro, ya kasance cikakke a cikin bincikensa, wanda masu bincike suka ce sun "yi nasara" kuma suna da "sakamako mai mahimmanci ga miliyoyin marasa lafiya da ke dauke da thyroxine yau da kullum."
Sakamakon binciken
A cikin dukkan marasa lafiya, TSH ya rage yawan kuɗin na thyroxine (T4) ta hanyar canza canjin thyroxine daga safiya zuwa kwanta barci. Harshen Triiodothyronine (T3) ya tashi a cikin duka sai dai daya batun.
Abin sha'awa, TSH ya rage ba tare da la'akari da matakan TSH na farawa ba, yana ba da shawarar yin amfani da maganin maganin thyroid a lokacin da aka kai shi da maraice.
A ƙarshe, masu bincike sun gano cewa adadin circadian TSH-yawancin yau da kullum na TSH da ke faruwa a lokacin awa 24 - bai bambanta ba.
Nazarin Tattaunawa
Masu bincike sun ba da shawara da yawa don sakamakon:
- Ko da lokacin da ake jira akalla minti 30 don cin abinci, karin kumallo zai iya zama tsangwama tare da ciwo na intanet na levothyroxine.
- "Maganin motsa jiki yana da hankali a daren," wanda ke nufin cewa yana da tsayi don levothyroxine kwamfutar hannu don tafiya ta hanyar tsarin intestinal, wanda zai haifar da tsinkayar tsawon lokaci zuwa ga bango na intestinal, sabili da haka, yafi magani da tsinkayar magani.
- Hanyar fasalin T4 zuwa T3 zai iya zama mafi tasiri a maraice.
Masu bincike daga wannan binciken sun nuna cewa an ba da sakamakon wannan binciken, an buƙaci wani binciken da aka bazu a cikin baƙi don tabbatar da sakamakon su-kuma wannan shi ne binciken da aka ruwaito a cikin Tarihin Magunguna na Intanet .
Na biyu ya yi shawara Nighttime zai iya zama mafi alhẽri
A cikin wannan binciken, marasa lafiya 90 sun kammala gwajin, wanda ya shafi watanni shida na ɗaukar matsurar ruwa daya da safe da kuma ɗaya daga cikin matsurar a lokacin kwanta barci (tare da levothyroxine mai daukar nauyi guda ɗaya, ɗayan placebo, da sauyawa a cikin watanni uku) .
Masu bincike sun gwada matakan hormone thyroid, kazalika da matakan creatinine, matakan lipid, zane-zane na jiki, zuciya, da kuma muhimmancin sigogin rayuwa.
Sakamakon binciken
Masu binciken sun gano cewa marasa lafiya ɗauke da levothyroxine na dare suna da digo a TSH na 1.25 MU / L, wani canji mai mahimmanci. Daƙarin thyroxine kyauta ( free T4 ) ya karu da 0.07 ng / dL, kuma jimlar triodothyronine (total T3) ya haura ta 6.5 ng / dL. Babu wani canje-canje mai mahimmanci a wasu dalilai da aka auna.
Nazarin Tattaunawa
Masu bincike sun kammala cewa, saboda kyautatawa a cikin matakan hormone thyroid, likitoci ya kamata la'akari da rubutun levothyroxine da za a dauka a lokacin kwanta barci.
Abubuwa a gare ku ko ƙauna daya tare da hypothyroidism
Samun shan magani a lokacin kwanta barci maimakon a safiya zai iya ba da wasu daga ciki:
- Na farko, yana da sauƙi, kamar yadda ba ku damu da lokacin da za ku ci karin kumallo ba.
- Na biyu, yana da sauƙi don kauce wa magunguna, kariyan abinci, da abinci, irin su calcium, baƙin ƙarfe, da abinci masu fiber-fiber wanda zai iya tsoma baki tare da shayarwar magani na thyroid .
- Abu na uku, masu shan giya ba su jira har sa'a daya bayan shan magani su ji dadin kofin farko .
- Hudu, zai iya bayar da ƙarin cigaba a bayyanar cututtuka idan baza ku sami rinjaye mafi kyau ba ta hanyar shan maganin maganin ku a lokacin rana.
Wadannan nazarin sun tabbatar da abin da marasa lafiya suka bayar da rahoto akai-akai domin shekaru-sun ji daɗi idan sun dauki maganin maganin maganin maganin maganin karoid a maraice, maimakon safiya.
A ƙarshe, duk da haka, yana da muhimmanci a yi magana da likitanka game da canza lokacin da za a ɗauki jinsin levothyroxine ko alamar suna levothyroxine (alal misali, Synthroid). Idan kai da likitanka sun yanke shawara su ba shi tafiya da shan maganin thyroid a maraice, tabbas za a kimanta matakan thyroid (makonni shida zuwa takwas ne lokacin dacewa) bayan da ka canza.
Sakamakon gwajin jini, tare da duk wani cigaba ko ciwo da alamun bayyanar cututtuka, zai taimake ku da likitan ku ƙayyade idan kuna buƙatar gyara sashi ko dawo da baya don shan maganin ku da sassafe
Muhimmiyar Maganin Don Tsayawa a Zuciya: Nazarin Nazarin Nazarin Levothyroxine kawai
An gudanar da waɗannan nazarin tare da levothyroxine, wani nau'i na roba na T4 / thyroxine thyroid hormone. Wannan nau'i na hormone dole ne a fara tuba cikin jiki zuwa nau'i mai aiki (T3), kuma wannan zai ɗauki kwanaki.
Magungunan maganin da ke dauke da T3-irin su Cytomel, da kuma yanayin da ke tattare da kwayoyin maganin thyroid kamar Nature-throid da Armor Thyroid-suna amfani da su ta hanyar kai tsaye cikin sa'o'i. Wadannan kwayoyi ba a kimantawa a cikin binciken ba, kuma ba'a san cewa magunguna masu dauke da T3 ba, ko magungunan kwayoyin cututtukan karoid zasu zama mafi alhẽri a dare.
A takaice, wasu masu maganin thyroid sun bayar da rahoton kyautatawa a cikin bayyanar cututtuka lokacin shan wasu ko duk magungunan su na gyaran maganin hormone na T3 na T3 da yamma. Amma wasu masu ciwon maganin magunguna sun gano cewa idan sun dauki magani tare da T3 daga baya a rana ko da maraice, ƙananan magani na T3 zasu iya sa shi wuya a barci.
Saboda haka ka tuna cewa yayin da za'a yiwu idan an gudanar da irin wannan binciken tare da kwayoyi T3 , sakamakon zai kasance kama, amma akwai damar cewa zai tasiri darajar barci a wasu marasa lafiya. Ya kamata kuyi wannan canji bayan tattauna shi da likitanku.
Wasu likitoci sun bayar da shawarar cewa marasa lafiya waɗanda ke ɗauke da magungunan T3 suna yin amfani da tsarin saki na T3, ko raba su kuma suna shan maganin sau da yawa a cikin yini. Wannan tsarin yana da alama ya rage girman tsangwama; Duk da haka, sake, tabbatar da cewa kawai canza canjin ƙarƙashin jagorancin likitan ku.
Bugu da ƙari, idan kun yi canji ga yadda kuke amfani da T3 thyroid medication, za ku so a sake nazarin matakin jini da bayyanar cututtuka bayan da yawa makonni, don sanin idan kana bukatar ka daidaita sashi ko lokaci na magani.
Kalma Daga
Duk da yake sharuɗɗa masu dacewa suna bada shawarar maganin maganin hormon dinka na farko a safiya a kan komai a ciki (saboda hadarin abincin da zai shafe tare da sha), shan shan magani a cikin maraice zai iya zama mai hankali a wasu lokuta.
Wannan na iya kasancewa musamman gaskiyar ga mutanen da suke da wuya a jira awa daya kafin cin abinci da safe da / ko waɗanda suke shan magunguna ne da safe.
A ƙarshe, maɓallin yin amfani da maganin maye gurbin thyroid hormone shi ne daidaito, ɗaukar kwayar karoid a lokaci daya kowace rana, kuma a cikin hanya guda.
> Sources:
> Bach-Huynh TG, Nayak, B. Loh J, Sojan S, Jonklaas J. Jigon na Levothyroxine Administration rinjayar kwayar cutar Thyrotropin Concentration. Jaridar Clinical Endocrinology da Metabolism . 2009 Oktoba; 94 (10): 3905-3912. An wallafa shi a yanar-gizon 2009 Yuli 7. Doi: 10.1210 / jc.2009-0860
> Bolk N, Sauran TJ, Nijani J, Jongste IJ, Tijssen JG, Berghout A. Sauyewar Maraice vs Morning Levothyroxine Intake: A Zuciya Zuciya Crossover Trial. Tsaro na Magungunan Hoto . 2010; 170 (22): 1996-2003.
> Garber JR et al. Ka'idodin aikin magani na hypothyroidism a cikin tsofaffi: > Cibiyar Nazarin Ƙungiyar Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararrun Ƙwararru ta Amirka da Ƙungiyar Ƙasar ta Amirka. Endocr Pract. 2012 Nov-Dec, 18 (6): 988-1028.
> Rajput, R Chatterjee S, Rajput M. Za a iya Samu Levothyroxine a matsayin Maraice Dose? Binciken kwatanta na Morning zuwa da Saurin Dogon Levothyroxine a Gudanar da Hypothyroidism. Jaridar Thyroid Research . 2011; 2011: 505239. Doi: 10.4061 / 2011/505239. Epub 2011 Jul 14.