Pennsaid wani bayani mai zurfi na NSAID wanda ya karbi izinin FDA a ranar 4 ga watan Nuwamba, 2009, don magance ciwo da bayyanar cututtuka da suka hada da gwiwa osteoarthritis . Sunan launi na Pennsaid shine diclofenac sodium. Cibiyar bincike ta Nuvo Research Inc. ta fara nema. Wannan shi ne jerin litattafai na diclofenac, kuma yana samuwa a matsayin kwaya.
Yaya Yayi Ayyukan Taimako?
Duk wasu kwayoyin anti-inflammatory masu cututtukan steroidal (NSAIDs) suna aiki ta hanyar irin wannan tsari.
Suna hana cyclooxygenase, wani enzyme da ke da alhakin samar da prostaglandins, wanda shine mabudban magungunan sunadarai ga kwandon ƙwayar cuta. Ta hanyar hana wannan enzyme, NSAID yana haifar da ƙananan matakan prostaglandins kuma saboda haka ƙananan ƙonewa. Abin takaici, prostaglandins suna aiki ne a wasu ayyukan jiki, kuma ta haka ne NSAID suna da wasu tasiri masu tasiri. Hakanan, prostaglandins suna da mahimmanci wajen samar da membran mucous na ciki wanda yake da muhimmanci a kare kullun daga cikin acid. SAISU, ta hanyar rage yawan karuwanci, wanda zai haifar da rashin lalata wannan kariya ta kare kuma zai iya haifar da haushi da ulcers.
Ka'idar bayan yin amfani da NSAID masu mahimmanci ita ce aikace-aikacen gida na miyagun ƙwayoyi zai haifar da ƙananan ƙumburi, kuma haɗakar haɗari a ciwo a shafin yanar gizo, amma ƙwayoyi bazai kai ga ƙimar jini ba don kai ga farfadowa masu illa. irin su ulcers.
A gaskiya ma, nazarin ya nuna cewa tare da aikace-aikace na NSAID ƙananan tsarin miyagun ƙwayoyi ne kawai kimanin kashi 5 cikin dari na abin da suke cikin kyallen takalma inda ake amfani da miyagun ƙwayoyi.
Hanyoyin Ciki kamar Yakanin NSAID
Yin amfani da NSAIDs masu mahimmanci a jiyya na gwiwa osteoarthritis yana samar da gagarumin gagarumar amfani gastrointestinal ga wasu marasa lafiya.
Hanyar da ke bayan waɗannan amfanin kamar yadda aka bayyana a sama. Kulawa na asibiti na iya zama mafi aminci kuma mafi inganci idan aka kwatanta da na NSAID na baka.
Samun yiwuwar abubuwa masu ban sha'awa irin su ulcers , zubar jini , da kuma ciwon kwakwalwa na jini har yanzu suna kasancewa amma ba su iya kwatanta nau'in kwayoyin kwayoyi.
Sakamakon sakamako mafi rinjaye da ake danganta da Pennsaid shine m bushewa ko hangula inda aka yi amfani da shi.
Yana aiki ne?
Binciken da Cochrane Collaboration ya yi a kwanan nan yayi nazari da nazarin karatun 61 da suka binciki ko ayyukan NSAID. A takaice dai, amsar ita ce a'a. Lokacin hada bayanai daga dukkanin binciken, kimanin kashi 75 cikin dari na mutane sun sami babban taimako na ciwon tsoka / haɗin gwiwa (gudunmawar da aka ƙaddara a matsayin rage yawan jin zafi da rabi) yayin amfani da diclofenac, wannan ya bambanta da kimanin kashi 50 cikin dari na mutane sami placebo.
Sources:
Cochrane Review of Topical NSAIDs
> http://www.cochrane.org/CD007402/SYMPT_topical-non-steroidal-anti-inflammatory-drugs-for-acute-musculoskeletal-pain-in-adults
FDA ta amince da Pennsaid. Drugs.com.
http://www.drugs.com/newdrugs/fda-approves-pennsaid-topical-solution-1758.html
Pennsaid. NUVO