Cibiyar ta IBD da Ciwon daji

Ciwon jijiyoyin jini , ko kuma na IBD, sun hada da ciwon cututtuka da cutar Crohn. Dukansu biyu marasa cututtuka ne na cututtuka na tsakiya. Dukansu suna da maganin da zai iya rage ciwon daji da kuma asibiti.

Samun IBD kuma ana kulawa da ita don haɗari da ƙananan lymphoma, kuma hadarin ya bambanta tare da wasu dalilai ba tare da an kula da su ba.

Ƙunƙarar Flammatory Ciwo

IBD tasowa saboda kumburi a cikin hanji, wanda zai haifar da zub da jini, zazzabi, tasowa daga ƙwayoyin jinin jini , da cututtuka da kuma ciwon ciki na ciki. Abubuwa masu yawa a cikin IBD sun kasance a halin yanzu a cikin nazarin ilimin lissafi irin su CT scan, ko kuma wani colonoscopy, alal misali.

Lymphoma Hadarin

Mutanen da ke tare da IBD tare da wasu magunguna - irin su jami'o'in TNF da kuma maye gurbin masu gyara - suna samun haɗari ga wasu cututtuka da suka haɗa da kwayoyin jini na lymphocyte , bisa ga binciken da yawa. Akwai wasu rashin tabbas game da irin hadarin da akwai, duk da haka.

Lymphoma shine ciwon daji wanda ke farawa a cikin kwayoyin jini na lymphocyte, wadanda suke cikin sashin jiki na jiki. Hakanan lymphoma guda biyu sune Hodgkin da lymphoma ba Hodgkin (NHL) . Akwai nau'i iri iri da yawa . An lura da cewa NHL yana faruwa a sama da yadda ake tsammanin yawancin cututtuka daban daban da suke buƙatar karewa, kamar IBD.

Rashin lafiyar lymphoma ba daidai ba ne ga duk wanda ke da IBD. Risuka sun bambanta da abubuwa irin su tsofaffi, jinsi, da kuma sauran abubuwa. Tana ƙaddamar da hadari da kuma amfani da hanyoyin da ke ciki na IBD tare da likitanku wani ɓangare ne na yanke shawara. Yawancin lokaci, an yanke shawarar cewa amfanin dabarun wadannan maganin ya fi kusan ƙananan hadarin da aka jawo.

IBD Jiyya

Yin amfani da maganin ƙwayoyin cuta mai guba don IBD don yin gyare-gyare wanda ya biyo baya tare da maganin rigakafi tare da magungunan immunosuppressant har yanzu shine babban tsarin kula. Ciopurines - irin su azathioprine - ana amfani dasu a cikin farfadowa na ciwon ƙwayar cutar ciwon jini.

A cikin marasa lafiya tare da IBD da ake bi da su tare da cututtukan kwayar cutar, akwai ƙari mai yawa na ciwon daji na jini, amma yawancin cututtukan da suka haifar da sakamakon magani sunyi ƙananan ƙananan. A cikin mutanen da suka samu sifofin kwayoyin, NHL da ke hade da maye gurbin da ake kira da ake kira lymphoproliferative disorder, kuma wasu daga abin da aka sani game da ilimin lymphoma ya zo ne daga wannan rukuni na marasa lafiya.

An yi amfani da alamun lymphoma na musamman tare da masu amfani da rigakafi masu amfani da ita a IBD. Lymphoma bayan dashi shi ne daya daga cikinsu. Lymphoma bayan samun mononucleosis, ko kuma guda ɗaya, yana da yiwuwar, kuma wannan nau'i yana nuna damuwa ga matasa da yawa fiye da shekaru 35. Kwanan nan, lymphoma na T-cell zai iya bunkasa, kuma yana cigaba da ci gaba bayan akalla shekaru 2 na farfadowa tare da haɗuwa da thiopurines da ƙwayoyin cutar necrosis na kwayoyin cuta, ko kuma kwayoyin cutar kawai.

• Azathioprine ya haɗu da haɗarin lymphoma mai lamba 2.40 x a cikin binciken da aka buga a "American Journal of Epidemiology."

• Haɗuwa da azathioprine da kuma 6-mercaptopurine suna da haɗari na sama da rabi na 4.92 na bunkasa lymphoma tsakanin mutane tare da IBD, a cewar wani binciken da aka buga a "Clinical Gastroenterology and Hepatology."

Mafi ƙarancin an san game da hanyoyin da kuma ilimin lymphoma a IBD. Tare da magungunan TNF, bincike na 2009 ya gano cewa hadarin lymphoma tare da anti-TNF + immunomodulator ya fi mahimmanci ne kawai.

Layin Ƙasa

Akwai tambayoyin da ba a amsa ba game da ilimin lymphoma a cikin yanayin lafiya na IBD. Idan kuna da IBD kuma kuna bukatar farfadowa, zai fi dacewa don tattauna duk damuwa da kuke da shi game da ƙalubalen da likitanku, wanda zai iya taimakawa wajen sanya abubuwa a cikin hangen nesa da kuma taimakawa wajen inganta abubuwan da ke cikin abubuwan da kuka dace.

Ba tare da magani mai dace ba, marasa lafiya da cututtukan Crohn da cututtuka na ƙwayar cuta na iya zama da haɓakaccen rayuwa. Wasu likitoci sun nuna gaskiyar cewa muna iya magance ƙananan ƙwayoyin lymphoma tsakanin dubban marasa lafiya, da kuma shekaru da dama da ke haifar da mu yanke shawarar game da hadarin.

Abu daya abu ne tabbatacce: damuwa da damuwa da damuwa na yau da kullum suna hade da kowane irin matsalolin lafiya, don haka idan kai da likitanka sun yanke shawara cewa kana buƙatar magani, ba zai dace ka damu ba.

_Sources:

_{Pasternak B, Svanstrom H, Schmiegelow K, et al. Amfani da Azathioprine da Rashin Ciwon Cutar a Cutar Flammatory. Am. J. Epidemiol . 2013; 177 (11): 1296-1305.}

_{Kotlyar DS, Lewis JD, Beaugerie L, et al. Rashin lafiyar Lymphoma a marasa lafiya tare da Clammatory Bowel Ciwo da Azathioprine da 6-Mercaptopurine: A Meta-bincike. Clin Gastroenterol Hepatol. 2015; 13 (5) 847-858.e4.}

_{Bär F, Sina C, Fellermann K. Ciopurines a cikin cututtukan ƙwayar cutar ciwon jini. Duniya J Gastroenterol. 2013; 19 (11): 1699-1706.}

_{Sokol H, Beaugerie L. Harsashin ƙwayar cuta da cutar lymphoproliferative: ƙura yana farawa. Gut . 2009 Oktoba; 58 (10): 1427-36.}

_{Kandiel A, Fraser AG, Korelitz BI, Brensinger C, Lewis JD. Ƙãra haɗarin lymphoma tsakanin mai kumburi jinji cuta marasa lafiya bi da tare da azathioprine da 6-mercaptopurine. Gut. 2005; 54 (8): 1121-1125.}

_{Tambaya J, Brandt L, Lapidus A, et al. Rashin lafiyar ciwon daji na hematopoietic a cikin marasa lafiya tare da cututtukan ƙwayar zuciya. Gut. 2005; 54 (5): 617-622.}

_{Bhandari BM, Kroser JA, Bloomfeld RS, Lynch SP. Ƙunƙarar Flammatory Ciwo. Kwalejin Amirka na Gastroenterology. 2013.}

_{Siegel CA. Rashin lafiyar Lymphoma a Flammatory Bowel cuta. Gastroenterol Hepatol. 2009; 5 (11): 784-790.}