Magunguna da aka ƙaddara su ne sabon magani ga ciwon nono wanda za'a iya amfani dasu kadai ko a hade tare da wasu jiyya. Ba kamar maganin gargajiya na gargajiya ba wanda ke haifar da kwayoyin ci gaba da sauri, maganin kwantar da hankalinsu a kai tsaye kai tsaye akan kwayoyin cutar ciwon daji ko kuma alamar sakonni wanda ke taimakawa wajen bunkasa kwayoyin ciwon daji. Saboda wannan dalili, yawancin kwayoyi na iya samun rassa masu rinjaye fiye da chemotherapy.
An samo hanyoyin kwantar da hankali don wadanda ke da cututtukan mai ƙirjin ƙirjin mai ciwon isrogen , HER 2 , tare da magungunan nono guda uku.
Wadannan kwayoyi na iya aiki sosai a wasu lokuta, amma kamar sauran magunguna da ake amfani da su don magance ciwon ƙirji na nono, juriya yakan bunkasa lokaci. Wasu daga cikin wadannan kwayoyi suna amfani da su duka na farko da kuma cin zarafin nono, yayin da wasu ana amfani dasu gaba daya ga mutanen da ke fama da ciwon nono.
Ga HER2 Ciwon Cutar Kyau
Kamar yadda muka gani a baya, a cikin kimanin kashi 25 cikin 100 na ciwon ƙirjin nono, jinsin da aka sani a matsayin mai karbi na mutum mai girma 2 (ko HER 2 / neu) ya haifar da rashin fahimta na gina jiki HER 2 (masu karɓa) a kan jikin kwayoyin nono.
Hakazalika, a hanyar, ga hanyar da masu karɓar estrogen suke da alhakin sigina wani kwayar cutar ciwon daji don tasowa da haɓakawa, masu karɓar HER 2 na iya haifar da ci gaba da haɓakawa da cututtukan HER 2.
Magunguna da suke tsoma baki tare da wadannan masu karɓa suna shawo kan wannan sigina zuwa wadannan kwayoyin cututtuka, suna iyakance ci gaban su.
Magunguna wanda ke da manufa HER 2 sun hada da:
- Herceptin (trastuzumab) - An ba Herceptin IV sau ɗaya sau daya a mako ko sau ɗaya kowace mako uku. Hanyoyi masu illa sun hada da zazzabi da ƙusoshin farawa. Kunawar zuciya zai iya ci gaba a cikin kashi uku zuwa biyar cikin mutanen da aka bi da miyagun ƙwayoyi, amma ba kamar rashin lafiya na zuciya ba dangane da kwayoyin cutar shan magani kamar Adriamycin (doxorubicin), wannan ƙin zuciya zai iya zama mai karɓuwa idan an dakatar da magani. Sakamakon sakamako daga Herceptin yakan inganta a tsawon lokaci.
- Kadcyla (ado-trastuzumab) - Kaydcyla magani ne wanda ya hada da Herceptin da kuma magungunan ƙwayar cutar shan magani da ake kira emtansine. Sashin ɓangaren maganin miyagun ƙwayoyi yana ɗaukar HER 2 kwayoyin cutar ciwon daji, amma maimakon kawai hana mai karba don hana jarabawan ci gaba daga haɗuwa, ya ba da "nauyin da ya dace" - maganin ƙwayar cutar shan-jijiya-dama ga kwayoyin cutar kanjamau.
Herceptin ya ba da damar maganin ƙwayar cuta don shigar da kwayoyin cutar Kanada, inda aka saki emtansine. Yayinda wannan wakiliyar cutar shan magani ne mafi yawancin aka ba da dama ga kwayoyin cutar kanjamau, akwai magungunan miyagun ƙwayoyi a cikin tsarin kwakwalwa.
Saboda wannan dalili, miyagun ƙwayoyi na iya haifar da illa mai lalacewa wanda ya saba da kwayoyi na cutar shan-jijiya sun haɗa da maye gurbin ƙasusuwan da kuma neuropathy. Kaydycla zai iya tasiri ko da a cikin mutanen da Herceptin ba su da amfani. - Perjeta (Pertuzumab) - Perjeta ita ce FDA ta amince da cutar ciwon ƙwayar cuta a 2013 kuma karatun sun sami karuwa a cikin rayuwar rayuwar mata da ciwon ciwon daji na ciki (HER 2 tabbatacce) waɗanda aka magance su da miyagun ƙwayoyi. Ana iya amfani da shi kadai ko a haɗa tare da Herceptin ko chemotherapy.
- Tykerb (cututtukan) - Tykerb kuma yana kai hari ga HER 2 kwayoyin cutar Kanada mai kyau, amma ta hanyar daban daban fiye da Herceptin. Tykerb, wanda ba kamar Herceptin bane wani mai cutar ba, za'a iya amfani da shi kadai, ko a hade tare da Herceptin ko chemotherapy. Sakamakon sakamako mafi rinjaye shine rash wanda ya nuna kama da kuraje (amma ba a bi da shi ba) kamar yadda cututtuka ke ciki.
Hanyoyi na gefen waɗannan Magunguna
Herceptin, Kaydcyla, da Perjeta suna da irin wannan tsari na aikin kuma saboda haka, irin wannan tasiri. Ɗaya daga cikin ƙarin game da illa masu amfani da wadannan kwayoyi shine lalacewar zuciya. Kwararren likitanku na iya bayar da shawarar gwajin gwaje-gwaje don zuciyarka kafin ka fara waɗannan magunguna kuma za su shawarce ka game da bayyanar cututtuka wanda ya nuna ya kamata ka kira.
Ga mai karɓar maganin Isrogen mai cututtukan lafiya
Ga matan da ke dauke da kwayar cutar ciwon daji mai cututtukan kwayoyin cutar ta hormone, ana samo asibiti. Ana amfani da waɗannan kwayoyi ga mata wadanda ke da matsakaicin matsakaici (ko kuma wadanda suka kasance premenopausal kuma sun karbi maganin kutsawa na yarinya) don yin maganin wariyar hanzari.
Drugs sun hada da:
- Ibrance (palbociclib ) - Wannan miyagun ƙwayoyi ya hana enzymes da ake kira cyclin-dependent kinases (CDK4 da CDK6) kuma ana amfani dashi bayan ciwon kwakwalwa mai cin gashin jijiyar estrogen-positive a cikin mace postmenopausal ya zama tushen maganin hormonal. Ana iya amfani da shi tare da mai hana magatase irin su Femara (letrozole) ko tare da Faslodex mai amfani da antisrogen (fulvestrant.)
- Mai ba da amfani (everolimus) - Wannan magani yana kariya da sunadaran jiki a jikin da ake kira mTOR. Ana yin amfani da maƙaryata don amfani da kwayar estrogen da kuma HER 2 ƙwayar ƙwayar cuta bayan da ya zama mai tsayayya ga mai cin zarafin aromatase irin su Aromatase (farfadowa).
Ga Magungunan Ƙwayar Wuta ta Uku
Tumors wanda shine hazarin estrogen na korau, haɓakar mai kwakwalwa na progesterone, da kuma HER 2 korau (ciwon daji na uku) zai iya zama ƙalubalantar magancewa, kamar yadda cututtuka na hormonal da magungunan HER 2 ba su da tasiri. Yayinda aka yi amfani dashi a wannan lokaci, shirin Avastin da aka yi niyya za a iya la'akari da wasu mutane.
- Avastin (bevacizumab) - Ba a yi amfani da wannan ba don magance ciwon nono ba saboda wani lokaci mai tsanani na jini. Ana rarraba shi a matsayin mai hana maganin angiogenesis. Kalmar angiogenesis na nufin "sabon jini" kuma yana nufin sabon jini wanda ya buƙaci ya samar da damar ƙyale maycers suyi girma.
Masu maganin Angiogenesis suna aiki ne ta hanyar hana rigakafi daga karuwa da jini, kuma shine "yunwa" ciwon daji.
> Sources:
> DeVita, Vincent., Et al. Ciwon daji: Ka'idoji da Kwarewar Kayan Lafiya. Ciwon daji na nono. Wolters Kluwer, 2016.
> Liedtke, C., da H. Kolberg. Tsarin Kwayoyin Tsarin Kwayoyin Ciwon Kwayoyin Ciwon Nazarin Ciwon Kwayoyin Ciwon Kwayoyin Ciwon Kwayoyin cuta Dairy Care . 2016. 11 (4): 275-281.