Wasu masu bincike sun gaskata cewa amyloid cascade hypothesis mafi kyau ya bayyana dalilin cutar Alzheimer .
Duk da yake ba a amsa tambayoyin da yawa ba, ambaliyar amyloid cascade ta gabatar da cewa yawancin kundin peptide da ake kira amyloid-beta shine babban abin da ke faruwa a cikin cutar Alzheimer: Wannan tara ya tsara jerin abubuwan da zasu haifar da mutuwar kwakwalwar kwayoyin, kuma ƙarshe, Alzheimer ta cutar.
Ta yaya Amyloid-Beta zai iya kawo Alzheimer?
Amyloid-beta an samo shi ne daga babban furotin da ake kira amyloid precursor protein (APP). Masu bincike basu fahimci aikin APP duk da haka ba, amma yana iya tasiri aikin ƙwayoyin kwakwalwa. Ƙananan enzymes (da ake kira secretase) sun yanke wannan furotin a wurare daban-daban, kuma daya daga cikin samfurori na wannan "janyewa" shine peptide amyloid-beta. Wadannan peptides amyloid-beta sun shiga cikin abin da ake kira oligomers, kuma bisa ga amyloid cascade hypothesis, wadannan sunadarai ne masu guba ga ƙwayoyin kwakwalwa, suna haifar da matsalolin maganganun farko a cikin cutar Alzheimer. Daga bisani, wadannan oligomers suna samar da alamomin cutar Alzheimer, amma sune masu oligomers - idan sun saba da alamun - wadannan su ne ainihin magunguna masu guba.
Yayinda wasu shaidu da dama ke goyan bayan maganganun amyloid cascade, akwai wasu kalubale a gare ta.
Abu daya shine, amyloid-beta wanda ke tarawa a cikin takardu yana faruwa ne a cikin tsufa da kuma cutar Alzheimer. Ga wani, ƙididdigar wani nau'in gina jiki wanda ake kira tau nau'i ne wanda ya inganta mafi alhẽri tare da matsalolin da aka gano a cikin cutar Alzheimer fiye da plaques. A karshe, akwai wasu hanyoyi masu mahimmanci, irin su ambaliyar motsa jiki, wanda aka ba da shawara a matsayin bayani game da abin da ke haifar da cutar Alzheimer.
Source:
Christensen DD. Ciwon Alzheimer: ci gaban cigaban ciwon amyloid-gyaran gyaran maganin. CNS Spectr. 2007; 12: 113-123.
-Article Edited by Esther Heerema, MSW