Wadanne kwayoyi ne ake bunkasa don magance cututtukan Crohn da Ulcerative Colitis?
A cikin 'yan shekarun nan, maganin cututtukan zuciya na ƙwayar cuta (IBD) ya samo karin hankali daga kamfanoni da masu bincike. Nan gaba ga mutanen da ke da IBD sun fi haske fiye da haka, yayin da karin kwayoyi suna cikin bututun don magance wadannan cututtuka masu haɗari da kuma matsalolin haɗarsu.
Alicaforsen
Alicaforsen yana ƙarƙashin lasisi ta Atlantic Pharmaceuticals Limited.
Ana amfani da miyagun ƙwayoyi ta hanyar enema kuma an gwada shi don amfani da cututtukan ulcerative colitis da pouchitis . An ba Alicaforsen matsayi na miyagun ƙwayoyi marayu a Amurka da Tarayyar Turai.
Alequel
Enzo Biochem ya kammala nazarin Alequel a cikin marasa lafiya da rashin lafiya mai tsanani na Crohn. Da miyagun ƙwayoyi ne mai kula da mutum wanda ya samo asali mai gina jiki wanda aka halicce shi daga nama daga majin mai haƙuri kuma ana gudanar da ita. An sami nasarar samun kashi 50 bisa dari na marasa lafiya a kan miyagun ƙwayoyi, kimanin kashi 33 cikin dari tare da placebo. An shayar da miyagun ƙwayoyi, ba tare da tasiri ba.
Teduglutide
An kirkiro wannan sabon fili don amfani a duka IBD da ƙananan ciwon jiji (SBS) . SBS ne yanayin da ke haifar da cututtukan daji, ƙwaƙwalwa, damuwa, da ƙwannafi wanda ke faruwa a cikin mutanen da suka sami rabin (ko fiye) daga ƙwayar ƙwayar ƙananan su. Mafi yawan hanyar SBS an maimaita magungunan tiyata ne da ake amfani dasu don magance cutar Crohn.
Sakamakon sakamako na teduglutide ya zama kadan, yayin da sakamakon ya faru ne a cikin fili na intestinal. Mutane tare da SBS waɗanda suka halarci gwaji na teduglutide sun nuna dukansu sun haɓaka abinci mai gina jiki da nauyin jiki. Abubuwan da ba a san su ba da yawa sun hada da ciwon ciki, ciwon kai, canje-canje, da busa.
NPS Pharmaceuticals, mai ƙaddamar da teduglutide, ya kammala nazarin gwaje-gwaje a marasa lafiya da Crohn. Daga cikin marasa lafiya tare da Crohn, kashi 55 cikin dari sun sami raguwa bayan makonni takwas na yin amfani da miyagun ƙwayoyi, idan aka kwatanta da kashi 33 cikin dari na marasa lafiya suna samun wuri. Yawancin rahoton da ya faru ya faru shine redness a wurin da allura. An gudanar da wani binciken akan marasa lafiyar SBS.
An ba Teduglutide matsayin miyagun ƙwayoyi marayu a duka Amurka da Turai don amfani da shi a SBS. NPS a halin yanzu yana neman abokin hulɗar ci gaba don ci gaba da gwada miyagun ƙwayoyi don amfani da cutar Crohn.
Traficet-EN (CCX282)
Traficet-EN ne mai maganin ƙwayar cutar kwayar cutar wanda ake gwadawa yanzu don amfani da cutar Crohn ta hanyar sana'a, ChemoCentryx. A cikin jarrabawar ta ƙarshe (BABI-1), mafi yawan marasa lafiya da ke karbar maganin miyagun kwayoyi sun sami remission bayan makonni 36 kafin wadanda suka karbi wuri. An shayar da miyagun ƙwayoyi a cikin mahalarta nazarin a kan gwajin watanni 12.
Sources:
ChemoCentryx. "Shirin CCR9.". 2010. 26 Yuni 2010.
Enzo Biochem, Inc. "Alequel." . 2010. 26 Yuni 2010.
Isis Pharmaceuticals, Inc. "Kwayoyin Flammatory." . 2010. 26 Yuni 2010.
Margalit M, Israeli E, Shibolet O, Zigmond E, Klein A, Hemed N, Donegan JJ, Rabbani E, Goldin E, Ilan Y. "Wani gwajin gwajin gwaji guda biyu don magance cutar Crohn ta hanyar magance Alequel, wani cakuda na sunadarin sunadarai sunadarai: wanda ya dace da halayyar da ya dace. " Am J Gastroenterol Maris 2006 101: 561-568. 26 Yuni 2010.
NPS Pharmaceuticals. "Ayyukan Harkokin NPS". 2010. 26 Feb 2012.