Bayanin kulawa, Amfanin da Yanayi na Jiyya
Magungunan Phosphodiesterase-4 (PDE4) irin su Daliresp (roflumilast) su ne sababbin magungunan miyagun ƙwayoyi don ciwo na cututtuka (COPD ) da sauran cututtuka na huhu. Wadannan kwayoyi sunyi aiki don kawar da kumburi a cikin hanyoyi masu guba don mutanen da suke da tsayayyar magani. Daliresp (roflumilast) shine kawai mai hana PDE4 a halin yanzu an yarda a Amurka.
Yaya Ayyukan Phosphodiesterase-4-Inhibitors
Magunguna irin su Daliresp aiki ta hanyar katange sakamakon phosphodiesterase 4, wani enzyme wanda yayi aiki don karya ƙasa da kwayoyin da ake kira cyclic adenosine monophosphate (CAMP.) Sakamakon hakan ya karu a CAMP (domin ba a karya ta da phosphodiesterase 4) ba don rage yawan kumburi a da huhu a cikin sauran abubuwa.
Wani abin tunawa da COPD shine ciwon kumburi, kuma mutanen da ke tare da COPD da kuma asma suna da kariyar PDE4 da ke haifar da wannan ƙonewa.
Ta rage rage kumburi, magunguna irin su Daliresp na iya rage yawan halayen kamfanonin COPD, kuma rage yawan gyaran iska.
Mene ne Ma'aikatan Aikin PDE4 suke Yi?
Ta hanyar ƙarfafa matakan CAMP da rage ƙananan kumburi, masu hana kwakwalwar PDE4 na iya rage adadin ƙwaƙwalwar COPD da inganta aikin ƙwayoyin huhu. Ta hanyar karar cutar, suna iya haifar da suturar jiki.
Yana da muhimmanci a lura cewa wadannan kwayoyi ba su gyara kayan huhu ba, suna aiki maimakon rage ƙananan ƙwayar cuta kuma suna hana kara lalacewa da tabbatar da bayyanar cututtuka.
Yanayi Idan Za a Yi Amfani da Daliresp (Roflumilast)
Hanyoyin da za'a iya amfani daliresp sun hada da:
- COPD
- Asthma
- Psoriasis
- Psoriatic arthritis
Yaushe Ana Amfani da Shi?
PD64 masu hanawa irin su Daliresp suna amfani da su don inganta aikin huhu a cikin mutane tare da barga COPD waɗanda suke da tsayayyar maganin sa.
Tare da COPD suna ganin sun fi amfana ga mutanen da ke fama da cutar da ke fama da cutar da ke fama da cutar .
Tun da waɗannan kwayoyi suna aiki a kan kumburi na yau da kullum, ba a amfani dasu ba saboda hare-haren COPD ko fuka-fuka, amma don kulawa da cutar ta kullum.
Ba kamar magungunan ƙwayar cutar ba, Daliresp wani lokaci ne na yau da kullum, magani na maganin da aka samo don inganta aikin kwayar cutar a cikin marasa lafiya da aka bi da Salmeterol da Spiriva (tiotropium).
Sakamakon magunguna PDE4 ya bayyana ya zama ƙari tare da corticosteroids.
Hanyoyin Gaba
Babban mawuyacin sakamako na PDE4 masu haɗaka sun hada da zawo, tashin zuciya, da ciwon kai. Zai iya haifar da asarar nauyi, saboda haka ya kamata a kula da nauyi a yayin jiyya kuma ya haifar da alamar cututtuka ga wasu mutane.
Harkokin hulɗa
Saboda mota ta hanyar cytochrome P-450, masu hana maganin PDE4 na iya tsangwama (ƙãra ko rage) wasu magunguna kuma sun hadu da wannan hanya, misali, magunguna irin su erythromycin, cimetidine, kwayoyin maganin haihuwa, wasu magunguna, da sauransu.
Har ila yau Known As: PDE4, m phosphodiesterase-4 inhibitors
Sources:
Ferguson, G., da B. Make. Gudanarwa na barga na ciwon kwari na kwayoyin cuta. Na zamani. Updated 01/21/16.
Mulhall, A., Droege, C., Ernst, N., Panos, R., da kuma Zafar. Phosphodiesterase 4 masu kwantar da hankali don maganin cutar rashin ciwo mai kwakwalwa: wani bita na yau da kullum masu tasowa. Kwararren Kwararru a kan Drugs Research . 2015. 24 (12): 1597-611.
Reid, D., da N. Pham. Roflumilast: wani magani ne don maganin cutar ta jiki. Annals na Pharmacotherapy. 2012. 46 (4): 521-9.
Ƙungiyar Ma'aikatar Medicine ta Amurka. MedlinePlus. Roflumilast. Updated 08/15/12. https://www.nlm.nih.gov/medlineplus/druginfo/meds/a611034.html