Wasu mutane suna da kwayar cutar ta HIV fiye da wasu.
Halitta na farko da aka haɗa da cutar ta HIV an gano a tsakiyar shekarun 1990. An san shi a matsayin maye gurbin CCR5-Delta32 , yana da alama ya ba da karfi ga kamuwa da cutar HIV. Wannan maye gurbi ne aka samo mafi yawanci a wasu mutanen Turai. Wannan yana yiwuwa saboda an hade shi da jure wa cututtuka irin su kanananpox ko Bubonic Plague.
Pk Protein da HIV Resistance
A farkon 2009, an wallafa wani takarda sanar da cewa wani maye gurbin kwayoyin halitta zai iya ba da matakan adawa da HIV. Wannan maye gurbi yana nuna matakin bayyanar wani furotin da ake kira Pk. An gano Pk a kan nau'in kwayoyin jini. Musamman ma, an samo shi a kan iyakar sassan da ke iya cutar HIV. Wannan karamin bincike ya gano cewa kwayoyin da ke da matakan Pk sun kasance mafi wuya ga kamuwa da HIV fiye da kwayoyin halitta ba tare da Pk ba. Haka masana kimiyya sun wallafa wani binciken da ya nuna cewa mutanen da ke da wata cuta (cutar Fabry) wanda ya kara yawan matakan Pk yana da alaka da kwayar HIV.
Abin sha'awa, wannan juriya na jinsin ya taka muhimmiyar rawa wajen nazarin maganin aikin . Halin lafiyar Berlin ya haɗu da wani mutum wanda aka ba shi kasusuwan kasusuwa daga wani mai maye gurbin CCR5.
Haɗuwa da maganin rigakafi , wannan farfasa ya yi watsi da cutar daga tsarinsa. Kwayar cutar ta zama kamar an kawar da shi daga tafki mai bidiyo.
Lura: An yi nazari na 2009 a fili cewa jini na iya kare ku daga cutar HIV. Pk wata hanya ce ta tattake jini. Duk da haka, ba a yi amfani dasu ba kuma ba wani ɓangare na ko dai tsarin tsarin A / B / O ko Rh ba. Bugu da ƙari kuma, binciken da aka yi a cikin tambaya kawai ya dubi yiwuwar samuwa da kuma nazarin da suka gabata a cikin mutane kawai sun sami juriya akan irin nau'in kwayar cutar HIV. Saboda haka yana da mahimmanci kada a fadada sakamakon binciken. Da alama akwai mutane da maye gurbin da suke ƙara adadin Pk zai zama mafi tsayayya ga HIV fiye da mutane da ƙananan matakan Pk. Wannan bayanin zai iya haifar da sabon nau'in maganin cutar HIV. Duk da haka, a ce irin jini zai iya kare kariya daga kamuwa da kwayar cutar HIV.
Sources:
Dean M et al. "Tsarin kwayoyin cutar HIV-1 da ci gaba da cutar AIDS ta hanyar maye gurbin tsarin ginin CKR5. Hemophilia Growth and Study Development, Nazarin Jirgin Ƙungiyar Nazarin Ƙwararrun Ƙungiyar AIDS, Nazarin Jakadancin Hemophilia mai Mahimmanci, Ƙungiyar Tattalin Arziki na San Francisco City, Bincike mai zurfi." Kimiyya. 1996 Satumba 27; 273 (5283): 1856-62.
Galvani AP & Slatkin M. "Tattaunawa da annoba da karamin jigilar kwayoyi kamar yadda tarihin zabe na CCR5-Delta 32 ke nunawa." Sanarwar Natl Acad Sci US A. 2003 Dec 9; 100 (25): 15276-9 .
Lund N et al. "Kwayar ɗan adam na Pk histo-jini na samar da kariya daga cutar HIV-1." Jinin jini. 2009 Janairu 12. Epub gaba da bugu
Lund N et al. "Rashin yiwuwar kwayoyin halitta daga marasa lafiya da cutar Fabry zuwa kamuwa da cutar mai karfin zuciya tare da R5 kwayar cutar mutum." AIDS 2005; 19: 1543-6.
Symons J, Vandekerckhove L, Hütter G, Wensing AM, van Ham PM, Deeks SG, Nijhuis M. Tsanani a kan CCR5 coreceptor don maganin cututtukan cututtukan cututtuka ya nuna rashin karuwar ƙwayoyin cutar HIV a CXCR4 wadanda suka kamu da cutar HIV. Ƙungiyar Infect Dis. 2014 Aug 15; 59 (4): 596-600. Doi: 10.1093 / cid / ciu284.