Neulasta (pegfilgrastim) wani magani ne wanda ake amfani da shi a lokacin da yake shan ƙwayar nono don kara yawan ƙwayar jinin jini don rage hadarin cututtuka. Me kake so ka san game da wannan miyagun ƙwayoyi, ciki har da yiwuwar sakamako mai yiwuwa?
Neulasta (Pegfilgrastim) Overview
Neulasta (pegfilgrastim) magani ne da aka ba wa mutanen da suke da shi ko kuma ana sa ran su samo neutropenia-ƙaddamar da cutar chemotherapy (ƙananan neutrophil , wani nau'i na jini mai tsabta) a lokacin da yake fama da cutar shan nono.
Neulasta wani samfuri ne na haɗin gwargwadon ciwon gine-ginen kafa (G-CSF), wani fili wanda ya karfafa samar da kwayoyin jini a cikin kututture. Yana da ruwa mai tsabta wanda aka ba shi a matsayin harbi inda an saka maciji a karkashin fata kawai.
Neulasta wani magani ne mai dadewa wanda ake buƙatar ne kawai sau ɗaya bayan biyan jita-jita na chemotherapy, wanda ya bambanta da Neupogen (filgrastim), wanda ake bawa kowace rana ta hanyar allura.
Yi amfani da Ciwon Kankara
Chemotherapy don ciwon nono yana rinjayar dukkanin kwayoyin halitta a cikin jikinka, ciki har da sassan jiki mai laushi, wanda ya haifar da kwayar jini mai tsabta, sel jini, da kuma platelets. Wannan maye gurbin ɓawon jini a lokacin yaduwar kwayar cutar zai iya haifar da anemia (ƙananan jinin jinin jini), neutropenia (ƙananan neutrophil) da kuma thrombocytopenia (ƙananan ƙididdigar ƙaddarar.)
Ƙididdiga masu tsaka-tsakin ƙananan (wani lokacin ana kiransa ƙananan jini) yana iya zama mai tsanani a cikin cewa zai iya sanya mutane samun chemotherapy zuwa cututtuka.
Manufar amfani da Neulasta shine don taimakawa wajen hana waɗannan cututtuka.
Yadda Neulasta ke aiki
Yawancin lokaci, jikinka yana samar da furotin wanda ke ƙarfafa samar da neutrophils. Yayin da ake shawo kan cutar kumburi, an katse jikinka na neutrophils, Neulasta yayi aiki don tayar da samar da neutrophils, kuma yayi girma da kuma kunna tsakaran tsaka-tsaki.
Ta yaya aka ba Neulasta?
Za ku sami allura daga Neulasta kimanin sa'o'i 24 bayan kayar da chemotherapy. Maiyuwa bazai ba da wuri ba saboda yana iya zama ƙasa mai tasiri. Ba kamar Neupogen ba, wanda dole ne a ba shi akai-akai har sai tsayayyar tsakaicin neutrophil ya tashi, an ba Neulasta sau ɗaya kawai a zagaye na 2 ko 3 na chemotherapy. Zaka iya samun wannan allurar a hannunka na sama, ciki, cinya, ko buttocks.
Wasu masu ilimin ilimin likita masu ilimin likita sunyi wa kansu maganin kansu a rana mai zuwa na chemotherapy, da kuma "atomatik" ta atomatik. Wasu masu ilimin likita sun bada shawara cewa kuna da allura a asibitin ku ko kuma tare da likitan likitanku idan akwai rashin lafiyan haɗari ga miyagun ƙwayoyi.
Alternatives zuwa Neulasta
Kamar yadda muka gani a baya, madadin Neulasta (pegfilgristim) ne Neuopogen (filgristim). Wani lokaci masanin ilmin likita zai tambayi wane magani kake so. Yayin da kwayoyi suke aiki kamar yadda suke, akwai wasu bambance-bambance tsakanin Neulasta da Neupogen , har ma da yawan injections, da juriya, da kuma kudin.
Wasu Hanyoyin Farko
Ɗaya daga cikin abubuwan da yafi tasiri daga Neulasta shine rashin lafiyar jiki, kuma wannan shine dalilin da wasu masu ilimin likita suka fi son ka harbi har a asibitin.
Idan ka ba da kanka a wasanka a gida, ya kamata ka saba da bayyanar cututtuka na yiwuwar maganin rashin lafiyar ko anaphylaxis.
Zazzabi zai iya faruwa, kuma yana da mahimmanci ga likita don ƙayyade idan zazzaɓinka ya kasance saboda inuwa, ko kuma kamuwa da kamuwa da cuta da aka danganta da ƙimar jinin jini.
Kusan kashi ɗaya cikin uku na mutanen da aka ba da maganin Neulasta sun ambaci wasu nau'i na ciwon nama. Binciken da aka yi a baya ya gano cewa Naprosyn / Aleve (naproxen) ya rage duka ciwo da kuma barci (yiwuwar saboda ciwo na nama). Kwanan nan an gano cewa antihistamine Claritin (loratidine) duka sun rage hadarin mummunar tasiri kuma sun sa mutane da yawa su dakatar da magani fiye da waɗanda aka bi da Aleve / Naprosyn (naproxen).
Idan kunyi fushi na mutum, ku yi magana da likitan ku game da abin da ta bada shawarar yin amfani da shi. Sake a cikin wanka mai dumi kuma zai iya taimakawa tare da ciwo daga Neulasta.
Kira Doctor ɗinka idan Kana da waɗannan cututtuka
Ƙananan sakamako mai lalacewa da halayen halayen zai iya faruwa, kuma yana da muhimmanci a kira mai likitancin ku idan kuna da wasu alamomin da ke damunku. Wannan yana da mahimmanci idan kun lura:
- Rashin jimawa da rashin jin dadi
- Ƙunƙun zuma
- Zuciyar zuciya
Kwayoyin cututtuka na gaggawa sun hada da
Ya kamata ku kira likitan ku nan da nan, amma ku nemi likita a hankali (kira 911) idan kun lura da duk wani bayyanar cututtuka da ke ba da labari game da wani anaphylactic reaction (rashin lafiya mai tsanani) kamar:
- Hives
- Dama mai wuya
- Kusawar fuska, lebe, harshe, ko wuya
- Raguwa yana yadawa jikinka
- Abun ciki mai zafi, musamman ciwo a cikin ƙananan hagu na hagu
- Babban mummunan rauni
Rashin yiwuwar Risks na Amfani da Neulasta
Neulasta wani magani ne mai kyau wanda ake amfani dashi ga yawancin neutropenia, kuma mafi yawan lokutan, sakamakon lalacewa ko hadarin shan magani ya wuce hadarin ƙimar tsaka-tsaki mai tsayi. Hanyoyin halayen da ba su sani ba (amma wani lokaci sukan faru) sun hada da:
- Abubuwa masu haɗari masu tsanani.
- Ƙungiyar ciwo na numfashi na numfashi (ARDS) .
- Ciwon sikila cikin mutanen da ke da ciwon sikila.
- Splenic rupture .
- Samun damar bunkasa ƙwayar tumo (wannan abu ne mai yiwuwa kuma ba a nuna shi ba, kamar yadda Neulasta yake girma)
Wa ya kamata ya guje wa wannan kwayar cutar
Kada ku dauki wannan magani idan:
- Kuna da ciki ko nono
- Kuna rashin lafiyan Neulasta
- Kuna rashin lafiyan samfurori da aka yi amfani da kwayoyin E. coli
Bayanai yayin Jiyya
Kafin ka fara allura na Neulasta, likitanka zai umurci CBC na gaba (cikakkar jinin jini) don ganin matakan da ke jikin ka da launin jini da jini, tare da kulawa na musamman ga cikakkiyar adadin tsaka-tsaki a cikin jini. Yayin da magani ya ci gaba, za ku sami ƙarin gwaje-gwajen jini don bincika tasiri na Neulasta.
Idan kana yin hayar ko ciki, tattauna wannan tare da likitanka kafin ka ɗauki Neulasta. Babu kimanin binciken da aka yi don sanin sakamakon wannan magani a kan nono madara ko ɗan mutum.
Rage Rashin Ciwo na Cutar Aiki a lokacin Masarar cutar
Koda koda kuna samun injections na Neulasta don tayar da ƙwayar jinin ku, za ku iya zama cikin hadari na bunkasa kamuwa da cutar a yayin yaduwar cutar. Wani lokaci lokutan jinin jini, ko da idan akwai isa, kada kuyi aiki. Kuma koda ta yin amfani da Neulasta, zaka iya samun lokuta bayan jigilar ka a yayin da karen jinin ku ya fāɗi a kasa da matakan da ake iya kamuwa da cututtuka. Ɗauki ɗan lokaci don koyi game da abin da zaka iya yin kanka don rage haɗarin kamuwa da cuta a yayin yaduwar cutar . Hint: wasu daga cikin wadannan matakan ba su da sananne kuma suna iya mamakin ku.
> Sources:
> Aapro, M., Boccia, R., Leonard, R. et al. Sake Gudanar da Matsayin Pegfilgrasti (Aikin G-CSF Mai Gudanarwa) don Yin Rigakafin Kwayar Kimiyya-Ƙaddamar da Lafiya ta Hankali: Shawarwarin Tattaunawa da Tattaunawa. Taimakon tallafi a Ciwon daji . 2017. 25 (11): 3295-3304.
> Botteri, E., Krendyukov, A., da G. Curigliano. Samar da kwatancen Granulocyte Colony-Mai Sanya Factor Filgrastim da Pegfilgrastim zuwa ga Biosimilars a cikin Terms of Efficacy da Safey: A Meta-Analysis na Randomized Clinical gwaji a Breast Ciwon daji marasa lafiya. Jaridar Turai na Ciwon daji . 2018. 89: 49-55.
> Kirshner, J., McDonald, M., Kruter, F. et al. NOLAN: A Randomized, Phase 2 Nazarin don Bayyana ƙwayar Prophylactic Naproxen ko Loratidine vs Babu Prophylactic Jiyya a kan Bone baƙin ciki a cikin marasa lafiya tare da Early-Stage Ciwon daji Cancer Karɓar Chemotherapy da Pegfilgrastim. Taimakon tallafi a Ciwon daji . 2018. 26 (4): 1323-1334.